Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis

Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis

“…30 In the present study, we attempted to elucidate the role of the IL-24 gene in predicting risk for psoriasis and to describe the linkage disequilibrium (LD) pattern of the IL-19, IL-20 and IL-24 genes. The association and haplotype analyses of the IL-24 gene were carried out.…”

Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma

“…2,5,6 In monocytes IL-19 secretion in response to LPS and GM-CSF has been shown to induce monocyte production of proinflammatory cytokines. 7 IL-19 expression is also upregulated in psoriatic lesions, [8][9][10] in sera from asthmatic patients, and in the urine of uremic patients, although the source of IL-19 production has not yet been identified. 11,12 Very little is known about the roles and the cellular sources of IL-19 in the lung.…”

Association analysis of IL20RA and IL20RB genes in psoriasis

“…7,8,10,16 Psoriatic lesions are characterized by increased expression of IL-19 and IL-20, which is normalized after treatment with cyclosporine or calcipotriol parallel to the clinical improvement of psoriatic lesions. 7,8 Although the data on the expression of IL-20R types I and II in psoriasis are somewhat controversial it seems possible that changes in the expression and/or function of IL-20-RI contribute to the changes of the IL-19 cytokine system that are part of psoriasis pathophysiology.…”

“…11,[15][16][17] For each SNP, a set of four primers was designed using the online program available at http: //cedar.genetics.soton.ac.uk/public_html/primer1.html. Each PCR reaction was carried out in a total volume of 10 ml, containing 100 ng of template DNA, 20 pmol of each inner primer, 2 pmol of each outer primer, 0.2 mM deoxyribonucleotide triphosphate, 1 Â reaction buffer (75 mM Tris-HCl, pH 8.8, 20 mM (NH 4 ) 2 SO 4 , 0.01% Tween 20, 0.1 mg ml À1 Tartrazine, 1% Sucrose (Naxo, Tartu, Estonia), 0.5 U Smart-Taq DNA polymerase (Naxo).…”

“…Evidence was obtained that the IL19 gene cluster represents a susceptibility region shared by plaque-type psoriasis and palmoplantar pustulosis (PPP), offering a possible explanation at the genetic level for the frequent co-existence of PPP and plaque-type psoriasis. [15][16][17][18] The biological activities of the IL-19 subfamily cytokines are mediated through binding to two distinct cell-surface receptors, the IL-20 receptor type I (IL-20-RI) and type II (IL-20-RII). Both receptors are heterodimers and share the IL-20RB protein as common subunit.…”