“…However, they could only report a marginal association, 36 and association to several clinical features but not directly to the disease; 37,44 only the microsatellite, IL10.G, showed a consistent significant association with SLE in various populations. 46,[47][48][49] As discussed elsewhere, 50,51 a large sample size should be used in association study to maintain statistical power to detect a significant association. Here, we have recruited over 1000 subjects (554 SLE patients and 708 healthy controls) and demonstrated the significant association between SLE and IL-10 promoter genotypes.…”