Abstract:Fifty-one cats histopathologically confirmed to have been naturally infected by feline infectious peritonitis (FIP), were collected to analyse the clinical and laboratory findings and to characterise disease staging. Effusive FIP was found in 33 cats, non-effusive FIP in 12 cats, and mixed-type in six cats. Highly significant decreases in haematocrit and albumin levels and an increase in total bilirubin level were noted in both effusive and non-effusive FIP, at first presentation and before death. In serial bl… Show more
“…Critical evaluation is necessary for a cat to be diagnosed with FIP. Diagnosis is based on evaluation of history, symptoms, hematological and biochemical parameters, diagnostic tests, radiology and tissue biopsy results (Shelly et al, 1988;Sparkes et al, 1994;Hartmann et al, 2003;Addie et al, 2009;Pedersen, 2009;Sharif et al, 2010;Tsai et al, 2011). It has been reported that up to 12% of FCoV infected cats develop FIP (Hartmann, 2005;Addie et al, 2009;Pedersen, 2009).…”
The presence of antibodies to feline coronavirus (FCoV) and feline immunodeficiency virus (FIV), together with feline leukemia virus (FeLV) antigen was investigated in 169 ill household and stray cats attending a veterinary surgery in Istanbul in 2009-14. The estimated FCoV and FIV seroprevalence (95% confidence intervals) were 37% (30-45%) and 11% (6-16%), respectively and FeLV prevalence was 1% (0-3%). FCoV seroprevalence increased until 2 years of age, was highest in 2014 and among household cats living with other cats and with outdoor access, and was lower in FIV seropositive compared to seronegative cats. Symptoms typically associated with wet feline infectious peritonitis (FIP) including ascites, abdominal distention or pleural effusion, coupled in many cases with non-antibiotic responsive fever, were observed in 19% (32/169) of cats, and 75% (24/32) of these cats were FCoV seropositive. FCoV seropositivity was also associated with a high white blood cell count, high plasma globulin, low plasma albumin and low blood urea nitrogen. The percentage of FCoV seropositive and seronegative cats that died in spite of supportive veterinary treatment was 33% (21/63) and 12% (13/106), respectively. These results indicate that FCoV is widespread and has a severe clinical impact in cats from Istanbul. Moreover, the incidence of FCoV infections could be rising, and in the absence of effective vaccination cat owners need to be made aware of ways to minimize the spread of this virus.
“…Critical evaluation is necessary for a cat to be diagnosed with FIP. Diagnosis is based on evaluation of history, symptoms, hematological and biochemical parameters, diagnostic tests, radiology and tissue biopsy results (Shelly et al, 1988;Sparkes et al, 1994;Hartmann et al, 2003;Addie et al, 2009;Pedersen, 2009;Sharif et al, 2010;Tsai et al, 2011). It has been reported that up to 12% of FCoV infected cats develop FIP (Hartmann, 2005;Addie et al, 2009;Pedersen, 2009).…”
The presence of antibodies to feline coronavirus (FCoV) and feline immunodeficiency virus (FIV), together with feline leukemia virus (FeLV) antigen was investigated in 169 ill household and stray cats attending a veterinary surgery in Istanbul in 2009-14. The estimated FCoV and FIV seroprevalence (95% confidence intervals) were 37% (30-45%) and 11% (6-16%), respectively and FeLV prevalence was 1% (0-3%). FCoV seroprevalence increased until 2 years of age, was highest in 2014 and among household cats living with other cats and with outdoor access, and was lower in FIV seropositive compared to seronegative cats. Symptoms typically associated with wet feline infectious peritonitis (FIP) including ascites, abdominal distention or pleural effusion, coupled in many cases with non-antibiotic responsive fever, were observed in 19% (32/169) of cats, and 75% (24/32) of these cats were FCoV seropositive. FCoV seropositivity was also associated with a high white blood cell count, high plasma globulin, low plasma albumin and low blood urea nitrogen. The percentage of FCoV seropositive and seronegative cats that died in spite of supportive veterinary treatment was 33% (21/63) and 12% (13/106), respectively. These results indicate that FCoV is widespread and has a severe clinical impact in cats from Istanbul. Moreover, the incidence of FCoV infections could be rising, and in the absence of effective vaccination cat owners need to be made aware of ways to minimize the spread of this virus.
“…Em alguns casos, a suspeita clínica de peritonite infecciosa felina pode estar relacionada à semelhança de sinais clíni-cos entre as duas enfermidades e faixa etária em que elas se apresentam (Pedersen 2009, Tsai et al 2010. Em parte dos casos a suspeita clínica foi de intoxicação, relacionada ao fato de ambas as doenças apresentarem convulsão como sinal clínico e curso agudo (Arnot et al 2011).…”
Feline panleukopenia is an important infectocontagious disease of domestic feline, especially in animals under 1 year. This paper describes the clinical-pathological findings and the immunohistochemical diagnosis of 33 cases of feline panleukopenia. The most important clinical signs were vomiting, diarrhea, and anorexia. The main gross findings observed were reddening of intestinal mucosa (16/33), evidentiation of Peyer patches (14/33), and liquefied intestinal content (7/33). The most consistent histological findings were necrosis (33/33) and lymphohistiocytic inflammatory infiltrate in the intestinal mucosa (31/33), villus fusion (27/33) and villus atrophy (26/33). In the hematopoietic tissues, the findings were characterized mainly by necrosis and tissue depletion. Parvovirus positive immunohistochemichal results were obtained in 84.85% of the cases analyzed. The best organ for viral detection was the intestine, with 84.85% of labeling in the immunohistochemichal technique. The spleen showed the best result among lymphoid organs, with 47.37% of the sections positive. This study presents most important lesions in the small intestine and in lymphoid organs and the immunohistochemistry proved good results in the detection of parvovirus.
“…1 In one study in Taiwan, 88% of 51 FIP-confirmed cats were less than 2 years old. 72 The risk decreases to 4% when cats reach 36 months of age. 65 The disease is overrepresented in certain pure breeds, but the incidence of FIP can vary greatly between regions and countries.…”
Section: Fip Incidence and Risk Factorsmentioning
confidence: 99%
“…65 The disease is overrepresented in certain pure breeds, but the incidence of FIP can vary greatly between regions and countries. Abyssinian, Australian mist, Bengal, Birman, British shorthair, Burmese, Cornish rex, Himalayan, Persian, ragdoll, and rex breeds have been suggested as risk factors, [71][72][73][74] but FIP development is probably more related to bloodlines within a breed than to breeds themselves. 59 It has been demonstrated that the development of FIP in certain lineages occurs at higher frequencies than other lineages, independently of environment, antibody titers, or viral shedding patterns.…”
Feline infectious peritonitis (FIP), a fatal disease in cats worldwide, is caused by FCoV infection, which commonly occurs in multicat environments. The enteric FCoV, referred to as feline enteric virus (FECV), is considered a mostly benign biotype infecting the gut, whereas the FIP virus biotype is considered the highly pathogenic etiologic agent for FIP. Current laboratory tests are unable to distinguish between virus biotypes of FCoV. FECV is highly contagious and easily spreads in multicat environments; therefore, the challenges to animal shelters are tremendous. This review summarizes interdisciplinary current knowledge in regard to virology, immunology, pathology, diagnostics, and treatment options in the context of multicat environments.
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