Clinicopathologic Importance of Women with Squamous Cell Carcinoma Cytology on Siriraj Liquid-Based Cervical Cytology

Abstract

Objectives: The purposes of this study were to determine the prevalence and predictive value to detect significant neoplasia and invasive lesions, and to evaluate the correlation between clinical and histopathology of women with squamous cell carcinoma (SCCA) on Siriraj liquid-based cervical cytology (Siriraj-LBC). Methods: The computerized database of women who underwent Siriraj-LBC at Siriraj Hospital, Mahidol University from January 2007 to December 2010 were retrieved. The hospital records of women with SCCA cytology were reviewed. Results: The prevalence of SCCA cytology was 0.07%. A total of 86 women, mean age was 58.1 years. Sixty-one women (70.9%) were post-menopausal. Overall significant pathology and invasive gynecologic cancer were detected in 84 women (97.7%) and 71 women (82.5%), respectively. The positive predictive values for detection of significant neoplasia and invasive lesion were 97.7% and 82.6%, respectively. The cervical cancer was diagnosed in 69 women and among these 58 women were SCCA. Thirteen women (15.1%) had cervical intraepithelial neoplasia (CIN) 3 and two women (2.3%) had cervicitis. The sensitivity and specificity of colposcopy for cervical cancer detection in SCCA cytology were 83.3% and 75%, respectively. Median follow up period was 17.6 months and 64 patients were alive without cytologic abnormality. Conclusions: The final histopathology of SCCA cytology in our populations demonstrated a wide variety, from cervicitis to invasive cancer and the most common diagnosis was invasive cervical cancer. Colposcopy with biopsy and/or endocervical curettage and loop electrosurgical excision procedure should be undertaken to achieve histologic diagnosis.

Performance of Siriraj Liquid-Based Cytology: a Single Center Report Concerning over 100,000 Samples

“…The PPV for CIN2+ increased with types of abnormal cytology, from 13.69% to 93.82%, in ASCUS, LSIL, ASC-H, abnormal glandular cytology, HSIL, and SCC, respectively. These results were comparable with the results in the first year of Siriraj-LBC and in other studies (Dupree et al, 1998;Papillo et al, 1998;Diaz-Rosario and Kabawat, 1999;Fremont-Smith et al, 2004;Ruengkhachorn et al, 2012). Our 4-year data strongly indicated that Siriraj-LBC, a low cost LBC technology, was qualified for cervical cancer screening.…”

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

“…Another study by Aue-aungkul et al (2011), in evaluating the clinical feasibility of the see and treat approach in managing Thai women with abnormal cervical cytology, from the same hospital reported that approximately 55.6% of women with SCCA cytology had invasive cervical lesions. An extraordinarily high incidence of underlying invasive lesion in women with SCCA cytology was concordantly found in recent reports from the other areas of Thailand by Ruengkhachorn et al (2012) and Kingnate et al (2014): 82.5% and 77.4% respectively. Thus, a high likelihood of harboring invasive disease in Thai women with SCCA smears should be kept in mind while taking care of women with SCCA cytology.…”

Overview of Nongynecological Samples Prepared with Liquid-Based Cytology Medium

“…A number of non-FDA-approved methods have been developed for use outside of the USA. These include LiquiPrep [4], Turbitec [5], PapSpin [6], TACAS [7,8], Siriraj-LBC [9], DNA-Citoliq (Digene) [10], GluCyte [11], and some other devices [12,13]. Specimen materials collected in the preservation medium are routinely used for cell blocks, which can provide additional diagnostic information, including architectural pattern, immunocytochemistry (ICC) and special stains.…”