Clinicopathologic Features and Outcome Predictors of Leptospira Interrogans Australis Serogroup Infection in Dogs: A Retrospective Study of 20 Cases (2001–2004)

Mastrorilli, Cinzia; Dondi, Francesco; Agnoli, Chiara; Turba, María Elena; Vezzali, Enrico; Gentilini, Fabio

doi:10.1892/0891-6640(2007)21[3:cfaopo]2.0.co;2

Cited by 59 publications

(154 citation statements)

References 8 publications

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“…The reason for higher concentrations of SAA in septic dogs may be related to inflammatory reactions and tissue damage. Similary, several studies have reported that CRP and SAA could be useful markers for diagnosis and prognosis in various disease [10,16,17,34,35] . However, CRP and SAA do not seem to be very spesific markers for the detection of bacterial infections because it might increase in a variety of diseases, not particularly in bacterial infections [10,16,17,35] .…”

Section: Discussionmentioning

confidence: 81%

“…In addition, increased CRP and SAA concentrations have been detected in dogs with systemic inflammation [10,16,17,30] . Furthermore, CRP and SAA were shown to be significantly increased in dogs with parvovirus enteritis [33] , ehrlichiosis [23] and leptospirosis [34] . C-reactive protein and SAA concentrations have been shown to be dramatically elevated in dogs with pyometra [18] .…”

Section: Discussionmentioning

confidence: 97%

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Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Ok¹,

Er²,

Yıldız³

et al. 2015

Kafkas Univ Vet Fak Derg

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The aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), interferon γ (INF-γ), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1ß, TNF-α, INF-γ, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1ß and TNF-α parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC). Keywords:

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 97%

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Ok¹,

Er²,

Yıldız³

et al. 2015

Kafkas Univ Vet Fak Derg

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“…Secondary hemostasis was evaluated by the assessment of PT and APTT. Endogenous antithrombotic activity was evaluated by measuring antithrombin III activity and by determining the concentration of TAT complexes; parameters used to define DIC in both humans and dogs (Moore and Williams, 1979;Furlanello et al, 2005;Máthé et al, 2006;Mastrorilli et al, 2007). It has been hypothesised that during the initial stages of DIC the patients are thought to be hypercoagulable as a result of circulating inflammatory mediators that activate haemostasis.…”

Section: Discussionmentioning

confidence: 99%

Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis

Rafaj

Matijatko

Kiš

et al. 2009

Acta Veterinaria Hungarica

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Changes in coagulation parameters were studied in dogs naturally infected with Babesia canis canis (n = 30), and haemostasis was evaluated and compared to values obtained from healthy dogs (n = 29). To date, there have not been any studies examining the dynamics of thrombin-antithrombin complex formation in cases of canine babesiosis. Coagulation parameters evaluated before (day 0) and on days 1, 2, and 3 after treatment with imidocarb (6 mg/kg inj. s.c.) included the determination of platelet counts, the formation of thrombin-antithrombin complexes (TAT), prothrombin time (PT), activated partial thromboplastin time (APTT) and antithrombin III (AT III) activity. TAT complexes were significantly elevated in animals with babesiosis on days 0 and 2 (mean 49.7 and 87.7 µg/L vs. control, 7.2 µg/L). AT III activity was significantly decreased at all time-points examined. There were no differences in PT. On days 2 and 3 the APTT was significantly shortened in the infected dogs when compared to control animals (means of 21.3 and 19.2 s vs. control, 30.0 s). Our analysis demonstrated that infected dogs had significant thrombocytopenia during the course of the study (mean day 0 -29 × 10 9 /L, day 1 -48 × 10 9 /L, day 2 -47 × 10 9 /L and day 3 -87 × 10 9 /L, vs. control -259 × 10 9 /L). These data suggest that babesiosis in dogs compromises primary and secondary haemostasis and that induction of disseminated intravascular coagulation (DIC) occurs in canine babesiosis.

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“…Interestingly, severe parvovirus enteritis in dogs in the same study showed an elevated CRP concentration (> 180 mg/L) which was not accompanied by elevated Hp values (>4 g/L) , thus suggesting that along with severe sepsis, there could be a complication due to gastrointestinal haemorrhage Figure 2. Approach to C-reactive protein and haptoglobin concentrations in infectious diseases in dogs [17,18,22,23,27,40,41,50] or haemolysis present in all severe cases [18]. Diminished plasma concentrations of Hp were reported in patients with various haemolytic diseases [19] and haemorrahage or haemolysis associated with haemolytic anaemia [20] as Hp has been identifi ed as the principal scavenger of free haemoglobin in the blood [21].…”

Section: Dogsmentioning

confidence: 99%

“…After intraperitoneal inoculation of Leptospira interrogans serovar canicola in beagles, CRP concentration peaked between 2 to 4 days coinciding with a brief or mild pyrexia and increased alkaline phosphatase concentrations [26]. C-reactive protein and haptoglobin levels were increased in dogs with symptomatic leptospirosis [27].…”

Section: Dogsmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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Clinicopathologic Features and Outcome Predictors of Leptospira Interrogans Australis Serogroup Infection in Dogs: A Retrospective Study of 20 Cases (2001–2004)

Abstract: Among the evaluated clinicopathologic biomarkers, serum albumin, cardiac troponin I, CRP/Hpt, urinary albumin, and urinary total protein to creatinine ratio were found to predict outcome and warrant evaluation in larger prospective studies.

Cited by 59 publications

References 8 publications

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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