Clinicopathologic and Cytomorphologic Features of Metastatic Neoplasms to the Thyroid Diagnosed by Fine Needle Aspiration and Core Needle Biopsy

Rahman, Mobeen; Okada, Ashley; Tauchi-Nishi, Pamela

doi:10.1016/j.jasc.2015.09.169

Cited by 3 publications

(11 citation statements)

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“…According to the literature, the most common sources of metastatic tumours in the thyroid are the breast, larynx and lungs. [3][4][5][6] However, in our study, the oesophagus was the most frequent source of primary tumours. Most authors of this study agreed that without a clinical history, it is difficult to diagnose metastatic tumours in the thyroid on cytomorphology alone.…”

Section: Discussioncontrasting

confidence: 48%

“…The period of time between the detection of the primary tumour and metastasis varies from a few months to several years. [3][4][5][6] However, we encountered metastatic lesions in the thyroid within just a few months of diagnosing primary tumours. According to the literature, the most common sources of metastatic tumours in the thyroid are the breast, larynx and lungs.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, extracellular material such as keratin, mucus and melanin pigments are also indicators of metastasis. [3][4][5][6] It is worth mentioning that ICC is often helpful in confirming metastatic tumours in the thyroid. 5,6 Depending on the situation, one can The literature on metastasis to the thyroid is sparse and limited.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6] It is worth mentioning that ICC is often helpful in confirming metastatic tumours in the thyroid. 5,6 Depending on the situation, one can The literature on metastasis to the thyroid is sparse and limited. Only a few case series and a handful of case reports have been published.…”

Section: Discussionmentioning

confidence: 99%

“…Rahman et al 6 diagnosed five cases of metastasis in a total of 13,182 thyroid FNAC samples, with a total incidence of 0.03%.…”

Section: Ta B L E 3 Comparison Of Different Studies Of Metastatic Tum...mentioning

confidence: 99%

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Fine needle aspiration cytology of metastatic tumours to the thyroid

Saini

Gupta

et al. 2023

Cytopathology

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Metastasis to the thyroid occurs infrequently. The incidence of secondary thyroid tumours has been reported to be as low as 2%-3% of all malignant tumours of the thyroid. 1,2 The preoperative diagnosis of metastatic deposit in the thyroid gland is difficult as it may simulate a benign nodule, and the correct diagnosis is often revealed postoperatively. Fine needle aspiration cytology (FNAC) is helpful in diagnosing both primary and secondary tumours in the thyroid.However, there are only a few reports of metastatic malignancy of the thyroid diagnosed by FNAC. 3,4 In this paper, we describe the cytological and clinical features from a series of FNAC samples of metastatic malignancy in the thyroid along with differential diagnoses.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Rahman et al 6 diagnosed five cases of metastasis in a total of 13,182 thyroid FNAC samples, with a total incidence of 0.03%.…”

Section: Ta B L E 3 Comparison Of Different Studies Of Metastatic Tum...mentioning

confidence: 99%

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Fine needle aspiration cytology of metastatic tumours to the thyroid

Saini

Gupta

et al. 2023

Cytopathology

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Small-Cell Malignancies of Thyroid: Challenge Solved?

Canberk¹,

Thodou²,

Bongiovanni³

2022

Acta Cytologica

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“Small-cell malignancies of thyroid” is an unsolved dilemma. This term represents an umbrella terminology in thyroid, encompassing for a small group of tumors in which some of them are well-recognized tumors like medullary thyroid carcinoma, poorly differentiated thyroid carcinoma, and primary thyroid lymphomas and teratoma, whereas the remaining are less known as primary neuroendocrine carcinoma of thyroid, primary extraskeletal Ewing family tumors, and adamantinoma-like Ewing sarcoma. When the issue comes to evaluate a cytological sample predominantly composed of small-cell morphology, metastatic small-cell carcinomas to thyroid also should be excluded. In this review, our group focused on the main cytomorphological and clinical clues of each entity that help to set up a correct differential diagnosis. The literature discussions were also included for the entities that are not yet recognized by the mother publication WHO. A key point of the issue’s simple algorithm based on FNAC with small-cell morphology of thyroid was suggested by the authors.

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Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management

Nguyen

Lam

2022

IJMS

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Secondary tumours to the thyroid gland are uncommon and often incidentally discovered on imaging. Symptomatic patients often present with a neck mass. Collision tumours of secondary tumours and primary thyroid neoplasms do occur. Ultrasound-guided fine-needle aspiration, core-needle biopsy, and surgical resection with histological and immunohistochemical analysis are employed to confirm diagnosis as well as for applying molecular studies to identify candidates for targeted therapy. Biopsy at the metastatic site can identify mutations (such as EGFR, K-Ras, VHL) and translocations (such as EML4-ALK fusion) important in planning target therapies. Patients with advanced-stage primary cancers, widespread dissemination, or unknown primary origin often have a poor prognosis. Those with isolated metastasis to the thyroid have better survival outcomes and are more likely to undergo thyroid resection. Systemic therapies, such as chemotherapy and hormonal therapy, are often used as adjuvant treatment post-operatively or in patients with disseminated disease. New targeted therapies, such as tyrosine kinase inhibitors and immune checkpoint inhibitors, have shown success in reported cases. A tailored treatment plan based on primary tumour features, overall cancer burden, and co-morbidities is imperative. To conclude, secondary cancer to the thyroid is uncommon, and awareness of the updates on diagnosis and management is needed.

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Clinicopathologic and Cytomorphologic Features of Metastatic Neoplasms to the Thyroid Diagnosed by Fine Needle Aspiration and Core Needle Biopsy

Cited by 3 publications

References 0 publications

Fine needle aspiration cytology of metastatic tumours to the thyroid

Fine needle aspiration cytology of metastatic tumours to the thyroid

Small-Cell Malignancies of Thyroid: Challenge Solved?

Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management

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