Clinico‐radiographic evaluation of 1% alendronate gel as an adjunct and smart blood derivative platelet rich fibrin in grade II furcation defects

Abstract

PRF+ ALN treated defects exhibited better clinical and radiographic outcomes suggestive of enhanced periodontal regeneration when compared to PRF alone treated sites.

Synergistic Application of Platelet-Rich Fibrin and 1% Alendronate in Periodontal Bone Regeneration: A Meta-Analysis

“…Our study is the first RCT-based research that supports the superiority of PRF plus 1%ALN over PRF alone in periodontal bone regeneration. But we noticed that all RCTs reporting this combined strategy lacked an important control group which only received 1%ALN [10][11][12]. Although our meta-analysis showed PRF plus 1%ALN produced much better outcomes on periodontal bone regeneration than PRF alone, it's still necessary to know how much profit are acquired by using PRF plus 1%ALN in comparison to 1%ALN alone.…”

“…Search Results. After selection according to our preestablished protocol, 14 RCTs were included for quantitative meta-analysis [10][11][12][23][24][25][26][27][28][29][30][31][32][33]. The details of search procedure were presented in study flowchart ( Figure 1).…”

“…Based on updated knowledge of bone biology, it is well known that satisfactory bone regeneration relies on coordinated bone formation and resorption [9]. A new pharmacologic and clinical strategy that aims to simultaneous management of bone formation and resorption, namely concurrent application of PRF and 1%ALN, were proposed recently in order to achieve better periodontal regeneration [10][11][12]. Previous studies have reported that both PRF and 1%ALN were respectively promising in regenerating periodontal bone [7,15,16].…”

“…Certain bone anabolic agents, such as PTH, recombinant human growth factors, and platelet-rich concentrates, as well as the major antiresorption medications, namely, bisphosphonates (BPs), have already been showed to be effective in regenerating periodontal bone [1,7]. Moreover, since bone formation and resorption are coupled and coordinated with each other, concurrent application of anabolic and antiresorption agents are introduced in regenerative periodontology very recently [8][9][10]. However, there is a lack of evidence-based studies to answer whether this synergistic way was superior to single application until now.…”

Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats

“…11 To avoid these adverse effects, controlled clinical studies and animal studies have evaluated the efficiency of local/topical use of ALN gel adjunct to scaling and root planing in periodontitis treatment and demonstrated a new therapeutic possibility. [12][13][14][15][16][17] Recently, Wanikar et al 12 evaluated the effects of 1% ALN gel combined with platelet-rich fibrin in the treatment of class II furcation defects, evaluating bone defect volume through cone beam computed tomography, probing pocket depth, clinical attachment level, and horizontal probing depth. The results showed that the association of 1% ALN plus platelet-rich fibrin provided to obtain better results in periodontal treatment.…”