Clinical validation of the Neonatal Infant Stressor Scale with preterm infant salivary cortisol

Pourkaviani, Shaliz; Zhang, Xueying; Spear, Emily; D'Agostino, Madeline; Satty, Rebecca E; Liu, Shelley H.; Stroustrup, Annemarie

doi:10.1038/s41390-019-0713-0

Cited by 22 publications

(25 citation statements)

References 39 publications

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“…Regarding chronic items, having a nasogastric tube in situ is considered as being a little stressful, fasting for surgery is moderately stressful, and having a systemic infection is very stressful. The NISS does not measure stress experiences by infants, but recently, the cumulative stress exposure has been associated with cortisol measurements, which have proven to be one of the most precise physiological signs of reactions to stress [ 27 ]. Therefore, we believe that the NISS is a valid measure of infant stress.…”

Section: Methodsmentioning

confidence: 99%

Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands

Kraft

Jaschke

Ravensbergen

et al. 2021

IJERPH

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Having an infant in the neonatal intensive care unit (NICU) elicits maternal anxiety, which may hamper parent−child bonding. We performed a prospective cohort study to describe anxiety in mothers of infants born before 30 weeks of gestation during NICU stay in The Netherlands, and investigated the influence of infant stress and gestational age. Second, we performed a randomized-controlled live-performed music therapy trial (LPMT trial) to investigate whether music therapy applied to the infant alleviated maternal anxiety. The relation between infant stress, gestational age, and maternal anxiety was measured in 45 mother−infant dyads, using the Neonatal Infant Stressor Scale and the State-Trait Anxiety Inventory (STAI). The effect of LPMT on anxiety was assessed in 21 mothers whose infants were assigned to either LPMT (n = 12) or waitlist (n = 9). Mothers completed the STAI before and after this period. Maternal anxiety decreased over time in all mothers, and was strongly related with infant stress (r = 0.706, p < 0.001), but not with gestational age. Anxiety scores decreased by 12% after LMPT, and increased by 1% after a waitlist period (p = 0.30). Our results indicate that LPMT in the weeks after birth may accelerate the reduction of maternal anxiety. Further research should focus on the effects on mother−child bonding.

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Section: Methodsmentioning

confidence: 99%

Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands

Kraft

Jaschke

Ravensbergen

et al. 2021

IJERPH

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“…Secondly, we quantified the cumulative exposure to neonatal stress rather than how an infant experiences this stress. Still, the NISS correlates well with cortisol measurements [23], which have proven to be one of the most precise physiological measures of changes in the HPA axis, that are associated with infant stress [24].…”

Section: Discussionmentioning

confidence: 99%

Course of Stress during the Neonatal Intensive Care Unit Stay in Preterm Infants

Dokkum¹,

Kroon²,

Dijk³

et al. 2021

Neonatology

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Introduction: Understanding the course of stress during the neonatal intensive care unit stay may provide targets for interventions. Our aim was to describe the course of stress in preterm infants during the first 28 days of life, the influence of gestational age, and associations with clinical characteristics. Methods: In a single centre prospective cohort study, we included infants with a gestational age <30 weeks and/or birth weight <1,000 g. We measured stress over the first 28 days using the Neonatal Infant Stressor Scale (NISS). We plotted daily NISS total and subcategory scores by gestational age. The subcategories were (1) nursing, (2) skin-breaking, (3) monitoring and imaging, and (4) medical morbidity-related scores. We assessed associations of cumulative NISS scores over the first 7, 14, and 28 days with clinical characteristics using regression analyses. Results: We included 45 infants, with a median gestational age of 27 weeks. The mean daily NISS score was 66.5 (SD 8.7), with highest scores in the first 7 days of life. Scores decreased the slowest for the lowest gestational ages, in particular for nursing scores, rather than skin-breaking, monitoring and imaging, and medical morbidity-related scores. Adjusted for gestational age, infants with lower Apgar scores, sepsis, intraventricular haemorrhages, and on mechanical ventilation had significantly higher cumulative NISS scores at 7, 14, and 28 days. Conclusion: NISS scores varied greatly within infants and over time, with the highest mean scores in the first week after birth. The course of declining NISS scores in the first 28 days depended on gestational age at birth.

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“…O cortisol é o hormônio mais amplamente utilizado em pesquisas relacionadas à dor. (45) Já a alfa-amilase, configura-se como uma das enzimas mais importantes presentes na saliva, (46) que aumenta sob condições estressantes e induz a produção de catecolamina, refletindo a atividade simpática. (47) Isso faz com que a alfa-amilase seja um potencial biomarcador objetivo e um método não invasivo para a avaliação da dor.…”

Section: Campos Et Al 2011unclassified

Biomarcadores salivares na avaliação da dor: revisão integrativa

Rocha¹,

Freitas²,

Silva³

et al. 2022

Acta Paulista De Enfermagem

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Conflitos de interesse: nada a declarar. ResumoObjetivo: Identificar os principais biomarcadores salivares descritos, assim como as técnicas empregadas para coleta das amostras de saliva, em estudos relacionados à avaliação da dor em pacientes submetidos a procedimentos dolorosos ou portadores de patologias dolorosas.Métodos: Revisão integrativa da literatura, realizada pelas buscas bibliográficas nas bases Biblioteca Virtual em Saúde (BVS), MEDLINE/PubMed, CINAHL e EMBASE, com recorte temporal de 2009 a 2019 e período de coleta de dados entre outubro e novembro de 2019. Foram utilizados Descritores em Saúde (DeCs)e Medical SubjectHeadings (MeSH), para responder à pergunta norteadora: Quais são e como são utilizados os biomarcadores salivares na avaliação da dor? Foi realizada uma análise descritiva dos artigos, sendo os dados extraídos e registrados em uma planilha desenvolvida para o presente estudo.Resultados: Das 126 publicações identificadas, 22 artigos foram incluídos para a análise. Constatou-se que os artigos são, majoritariamente, desenvolvidos com adultos durante realização de procedimentos dolorosos ou portadores de patologias dolorosa. Os principais biomarcadores salivares avaliados foram a alfa-amilase e o cortisol, e as principais técnicas para coleta de saliva foram o Salivette ® e a coleta passiva.Conclusão: Os estudos indicam que a mensuração objetiva da dor é um desafio. Os principais biomarcadores salivares descritos são o cortisol e a alfa-amilase, sendo o Salivette ® a principal técnica utilizada para coleta das amostras de saliva. A dosagem das moléculas salivares é incipiente e empregada de forma complementar na avaliação da dor em pacientes de diferentes faixas estárias, submetidos à procedimentos dolorosos ou portadores patologias dolorosas.

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Clinical validation of the Neonatal Infant Stressor Scale with preterm infant salivary cortisol

Cited by 22 publications

References 39 publications

Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands

Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands

Course of Stress during the Neonatal Intensive Care Unit Stay in Preterm Infants

Biomarcadores salivares na avaliação da dor: revisão integrativa

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