Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer

Zohny, Samir F.; Fayed, Salah T.

doi:10.1007/s12032-009-9366-x

Cited by 49 publications

(46 citation statements)

References 34 publications

(42 reference statements)

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“…However, the role of CCL18 in cancer progression is controversial. CCC18 was reported to participate in immunosuppression of ovarian cancer [39], but was also associated with prolonged survival in patients with gastric cancer [40]. Cytokine profile analysis of breast tumor-associated macrophages showed that CCL18 is abundantly expressed and promotes migration and invasion of breast cancer cells by enhancing their adherence to extracellular matrix; the CCL18 level in blood or cancer stroma was found to be associated with metastasis of patients with breast cancer [41].…”

Section: Discussionmentioning

confidence: 99%

Altered levels of plasma chemokines in breast cancer and their association with clinical and pathological characteristics

Nariţa¹,

Șeclăman²,

Anghel³

et al. 2016

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Chemokines are a family of small, structurally related cytokines with chemoattractant and activation properties. In breast cancer, both epithelial cancer cells and cells within the microenvironment secrete chemokines with either tumor-promoting or anti-malignant potential. The equilibrium between these two chemokine activities plays a key role in the biology of the developing tumor, including its ability to metastasize. Here we evaluated the expression of chemokines in breast tumors and the plasma of breast cancer patients before treatment in order to identify a blood-based signature that could distinguish between malignant and non-malignant processes.We screened the mRNA expression of chemokine genes using cDNA microarray on homogenous, laser-capture microdissected breast cancer specimens. Further, using a protein array approach, we determined the levels of selected chemokines in the plasma of patients with breast cancer, benign breast tumors and healthy women. Finally, we analyzed the association between the levels of chemokines in breast and blood samples with the pathological characteristics of the disease.At mRNA level, 27 chemokines and 11 chemokine receptors were differentially expressed in cancers when compared with normal breast tissue. When compared to benign tumors, the only chemokine significantly upregulated in cancers was CXCL10. At protein level, with the exception of CXCL13, nine out of the ten selected chemokines (CCL2, CCL7, CCL18, CCL22, CXCL8, CXCL9, CXCL10, CXCL11 and osteoprotegerin) were significantly overexpressed in the plasma of breast cancers patients compared to healthy controls. After grouping, CXCL8, CXCL9 and CCL22 proved to be significant predictors for breast cancers as compared to healthy controls in a model of logistic regression. We found upregulation of CXCL8, CXCL11 and CXCL9 in triple negative carcinomas, CXCL9 in low proliferative carcinomas, and CXCL10, CCL7 and osteoprotegerin in poorly differentiated carcinomas. Furthermore, CXCL9 was overexpressed in lymph node negative tumors, whereas CXCL8 and CCL18 were higher in advanced stage carcinomas.We identified a panel of chemokines dysregulated in breast cancer that could be further investigated as prospective novel diagnostic markers or for therapeutic and prognostic applications.

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Section: Discussionmentioning

confidence: 99%

Altered levels of plasma chemokines in breast cancer and their association with clinical and pathological characteristics

Nariţa¹,

Șeclăman²,

Anghel³

et al. 2016

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“…In the process of metastasis, it is vital for tumor cell to arrest in mediums, regulated by series of stimulus or inhibitors in the microenvironment. CCL18 triggers integrin clustering and ECM adherence of tumor cells, which eventually contribute to enhanced invasion and metastasis (Zohny & Fayed, 2010;Narita et al, 2011). Essentially, CCL18 could specifically bind to PITPNM3, stimulate calcium signaling and induce directional migration.…”

Section: Discussionmentioning

confidence: 99%

“…Essentially, CCL18 could specifically bind to PITPNM3, stimulate calcium signaling and induce directional migration. As the functional receptor of CCL18, PITPNM3 could be phosghorylated and then trigger a series of actions, such as activation of praline-rich tyrosine kinase (Pyk2), a key component of focal adhesion complex (FAC) (Lev et al, 1999;Zohny & Fayed, 2010). In our study, we chose MDA-MB-231 cells, a breast cancer line with metastasis potential.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid

Hong

Shen²,

Xie³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells ,with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3. However, there hasn't been any research on effect of PA on breast cancer metastasis. Therefore, we pay attention to whether PA could suppress breast cancer metastasis, and how it works. Keywords

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“…Роль ММП-7 в диагностике РЯ оценили также F. Zohny и соавт [31]. В их работе определен уровень ММП-7 в сыворотке крови совместно с опухолевым маркером СА-125, который уже показал свою диагно-стическую и прогностическую значимость.…”

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“…Zohny и соавт. приводят аналогичные данные: исследователи не выявили достоверной разницы сы-вороточных уровней ММП-7 при различной распро-страненности процесса, степени дифференцировки опухолевых клеток и гистологических типах РЯ [31].…”

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