Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic function., J Clin Gastroenterol, 247e252, 39. [3] Đoki c M, (2016), Treatment of primary liver tumors with electrochemotherapy. [4] Edhemovic I., (2014), Edhemovic I Intraoperative electrochemotherapy of colorectal liver metastases , Journa of Surgical Oncology, 320e327, 110. [5] Marty M Electrochemotherapy e an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study., (2006), Electrochemotherapy e an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study, EJC Suppl, 3e13, 4.
Right portal vein ligation. Liver partition respecting right hepatic artery and bile duct. -Volumetry of the future remnant liver on the sixth day (546 cc).-Second time: Right hepatectomy: liver partition is complete. Liver remnant: Segment IV. It did not require transfusions, ICU stay 48 hours. Result: Mild jaundice and postoperative ascites, which were self limited.Discharge on the seventh day.On first month control: tomographic, clinical and laboratory markers were normal, good hepatic function and absence of liver nodules.Capecitabine adjuvant therapy is currently on course.The quality of life of the patients is good. Conclusion: In selected cases ALPPS is valid approch to achieve resectability of patients initially unresectable. In a short period time (7/10 days) this technique enables to accomplish R0 resection. Well then adyuvant therapy can be started.
Right portal vein ligation. Liver partition respecting right hepatic artery and bile duct. -Volumetry of the future remnant liver on the sixth day (546 cc).-Second time: Right hepatectomy: liver partition is complete. Liver remnant: Segment IV. It did not require transfusions, ICU stay 48 hours. Result: Mild jaundice and postoperative ascites, which were self limited.Discharge on the seventh day.On first month control: tomographic, clinical and laboratory markers were normal, good hepatic function and absence of liver nodules.Capecitabine adjuvant therapy is currently on course.The quality of life of the patients is good. Conclusion: In selected cases ALPPS is valid approch to achieve resectability of patients initially unresectable. In a short period time (7/10 days) this technique enables to accomplish R0 resection. Well then adyuvant therapy can be started.
The training module was developed by the staff of the department under the leadership of the head. Department of Academician of RAS, Professor I.V. Poddubnoy and Rector of FSBEI DPO RMANPO of the Ministry of Health of Russia, Corr. RAS, Professor D.A. Sychev.
Objectives: to provide a rationale for existing approaches for the evaluation of chemoresistance of ovarian cancer in vitro, to perform a comparative analysis of the methods and to assess the perspectives of their further application.Materials and methods. For the review preparation, we analyzed articles on experimental testing of ovarian cancer resistance to chemotherapeutic agents, available at biomedical literature databases SciVerse Scopus (158), PubMed (323), Web of Science (285), RSCI (64). The review cited 37 recent publications, 12 of them being published over the past three years, and 16 articles being referred as pioneer publications on techniques previously and used today.Results. Peculiarities of the main methods for assessing the resistance and sensitivity of a cancer to various chemotherapeutic drugs using primary cultures of tumor cells obtained from biopsy or surgical material are analyzed. Proliferative and metabolic activities as well as the level of cell death were considered as the main evaluated characteristics of tumor cells. The methodological features of the described methods are discussed, as well as the prospects for their further application.Conclusion. Predictive detection of chemoresistance of ovarian cancer is based on testing the viability of tumor cells in the presence of a chemotherapeutic drug. The results of studies of the key mechanisms of chemoresistance development in tumor cells provide the rationale for improving in vitro testing.
patients were 9 and after 11 courses of chimiotherapie respectively. Severe fibrosis and liver steatosis had 21 patients. Operative intervention e 210 min Occlusion hepatoduodenal ligament in 60 patients. The average blood loss e 200,0 AE110,0 ml. Results: Complications after surgery and 23(31.9 percent). Acute liver failure e 1 (1); postoperative bleeding 1(1), sepsis e 1(1). Non-specific complications had 18 patients and specific five, three of whom died. Conclusion: The complication and mortality rate after resection remains high. An increasing number of elderly patients requiring liver resection. To prevent severe postoperative complications must be strict adherence to anatomic principles of resection.
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