Clinical utility of antinuclear antibody tests in children

McGhee, Julie L; Kickingbird, Lauren M; Jarvis, James N.

doi:10.1186/1471-2431-4-13

Cited by 96 publications

(67 citation statements)

References 17 publications

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“…In our study 65% of patients were with RA while 35% of patients werewith SLE, our RA percent similar to Julius et al [9]. In this study all patients with+ANA were with SLE while in others ANA have been detected in less than 10% to greater than 70% of patients with RA [10,11], they found that 7.5% of RA patients were+ANA and RF -ve. The peak age incidence in the recent study was differ from that others, in the recent were (20-24) of SLE and (30-34) of RA, while the west last studies found that the peak age incidence of SLE (15-25) and (25-35) of RA.…”

Section: Discussionsupporting

confidence: 75%

“…This hypothesis is supported by the fact that environmental factors that associated with flares of lupus increase oxidative stress and subsequent apoptosis. Such factors include exposure to sun light and artificial UV light, pregnancy and infection 3 or may be due to some genetic factors, so further analysis in families have a history of RA and SLE may be helpful in predicting the detection of immune response and precise genetic susceptibility to RA and SILE, it will also be useful to include other gene markers like oil anti trypsine, which are thought to be associated with severe seropositive RA and SLE [13] from (Table 3 and 4) we can conclude that the incidence of SLE in female only in the following groups (10)(11)(12)(13)(14), (15-19) and (35-39). And no female or male patients with SLE in the following groups (40-44), and (50-54).…”

Section: Discussionmentioning

confidence: 99%

“…This study covered nearly the details for this correlation that does not discussed enough in other studies [4][5][6][7][8][9][10].…”

mentioning

confidence: 94%

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ANA, RF and CRP in Patients with Rheumatic Symptoms (SLE and/or RA) in the King Abdul-Aziz Hospital-Jeddah-Saudi Arabia

Bamujaly¹

2017

J Gen Pract

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Purpose of the research: This study was done to explore the ANA, RF and CRP in the patients with some of Rheumatic Symptoms Materials and methods:The studies were done for 103 patients with Rheumatic Symptoms and were included in this study and their sera tested for the presence of Antinuclear Antibody (ANA), Rheumatoid Factor (RF), and Creactive protein (CRP). Results:The results showed that 33% of the patients with Systemic Lupus Erythematosis (SLE) had+ve ANA, the remainder 67% of patients were with Rheumatoid Arthritis (RA), the incidence of SLE was 4: 1 female to male while of RA was 2: 1. The highest titers of ANA, RF, and CRP were in females. In the following age groups (10-14), (15-19) and (35-39) the incidence of SLE were in females only. No male or female with SLE in (40-44), (45-49) or (50-54).

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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ANA, RF and CRP in Patients with Rheumatic Symptoms (SLE and/or RA) in the King Abdul-Aziz Hospital-Jeddah-Saudi Arabia

Bamujaly¹

2017

J Gen Pract

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“…'nın 20 94 KÜ tanılı çocukta yaptığı çalışmada sadece 2 hastada ANA titresi 1/160 üzerinde saptanmış olup, <1/180 ANA titresinin sistemik lupus açısından %100 oranında negatif prediktif değere sahip olduğu McGhee ve ark. 21 tarafından ileri sürülmüştür. Başka bir çalışmada ise 94 hastanın 2'sinde ANA pozitifliği saptanmış olup, hastaların birinde jüvenil romatoid artrit, birinde artralji saptanmıştır 6 .…”

Section: Discussionunclassified

Kronik ürtikerli olgularımızın etyolojik değerlendirmesi

Ayyıldız¹,

Sözmen²,

Fırıncı³

et al. 2014

TURKDERM

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ÖzetAmaç: Çocukluk çağında sınırlı veri nedeniyle kronik ürtiker (KÜ) etyolojisi tam olarak anlaşılamamıştır. Bu çalışmada kronik ürtiker tanılı çocuklarda muhtemel etyolojik nedenlerin değerlendirilmesini amaçladık. Gereç ve Yöntem: Ocak 2011 ile Temmuz 2012 tarihleri arasında KÜ tanısı ile kliniğimizde izlenen 18 yaş altı 67 hasta retrospektif olarak analiz edildi. Kronik ürtiker tanılı hastalarda otoimmun hastalıklar, maliniteler, infeksiyonlar gibi etyolojik faktörler araştırıldı. Veriler ortalama±standart sapma (SD) ve yüzde (%) olarak belirtildi. İki grup karşılaştırması Mann-Whitney U metodu kullanılarak yapıldı. P<0,05 olması istatiksel açıdan anlamlı kabul edildi. Bulgular: Kronik ürtiker (KÜ) tanısı olan 67 hasta çalışmaya alındı. Erkek/kız oranı:22/45, ortalama semptom başlangıç yaşı 10,2±4,6 (1-17) yıl idi. Hastaların %7'sinde ANA titresi >1/100 saptanmış olup bu hastaların hiçbirinde romatolojik hastalığa ait klinik özellik belirtilmediği öğrenildi. Hastaların %13,7'sinde tiroid otoantikor pozitifliği olup, hepsine tiroidit tanısı konulduğu ve L-Tiroxin tedavisi başlandığı görüldü. Otolog serum deri testi hastaların %48,2 (n=28)'sinde pozitif olarak saptandı. Sonuç: Çocuklarda infeksiyonlar ve besinler önemli birer KÜ nedeni gibi görünmemektedir. Erişkinlerde olduğu gibi çocuklarda da KÜ etyolojisinde otoreaktif süreçler önemli bir yer tutmaktadır. Bu sonuçlar daha önce KÜ tanılı Türk çocuklarda yapılan çalışmalar ile benzer özelliktedir. (Türk derm 2014; 48: 13-6) Anah tar Ke li me ler: Kronik ürtiker, otolog serum testi, antinükleer antikor, tiroidit Sum maryBackground and Design: The etiology of chronic urticaria (CU) in childhood remains incompletely understood because of limited data. In this study, we aimed to examine possible etiologies of CU in children. Materials and Methods:We retrospectively analyzed the medical records of 67 children who attended our clinic and were diagnosed with CU between January 2001 and July 2012. We investigated the etiological factors contributing to chronic urticaria, such as autoimmune disorders, malignancies and infections. Data were presented as mean±standard deviation (SD) and percentage (%). The comparisons between two groups were conducted using the Mann-Whitney U test. A p value of less than 0.05 was considered statistically significant. Results: Sixty-seven children who met the criteria for CU were included in the study. Male/female ratio was 0.5 and the mean age at onset of symptoms was 10.2±4.6 (range: 1-17) years. In 7% of patients, ANA titers were over 1/100. None of the patients had clinical features of a rheumatic disease, 13.7% of the subjects were positive for thyroid autoantibody. All of them were diagnosed with thyroiditis and received L-thyroxine treatment. Autologous serum skin test was positive in 42.8% of the patients (n=28). Conclusion: In children, infections and foods did not appear to be important causative factors for CU. As in adults, the etiology of CU in children is mainly related to autoreactive processes. This result is similar to ...

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“…All these methods are subject to false-positive results, mainly when the evaluated patient is in the age range over 60. [28][29][30][31][32] Substrates used for ANA detection by means of indirect immunofluorescence -FANA -can be from rat liver cells or human larynx tumor cells (Hep-2 cells). Hep-2 cells are better due to their large nucleus and to the easy exposure of their components.…”

Section: Identification Methodsmentioning

confidence: 99%