Fator antinúcleo na dermatologia

Duarte, Artur

doi:10.1590/s0365-05962005000400010

Cited by 6 publications

(9 citation statements)

References 37 publications

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“…Antinuclear antibodies were positive in 5 of 26 patients (19.2%) with DLE without SLE and in seven of eight (87.5%) with DLE and SLE. In patients with DLE with criteria for SLE, anti‐DNA was found in lower proportion when compared with adult SLE patients, and anti‐RNP and anti‐Sm were found in a higher percentage (9). Anti‐Ro and anti‐La were positive in a proportion similar to that of adult LE patients (9).…”

Section: Discussionmentioning

confidence: 95%

“…In patients with DLE with criteria for SLE, anti‐DNA was found in lower proportion when compared with adult SLE patients, and anti‐RNP and anti‐Sm were found in a higher percentage (9). Anti‐Ro and anti‐La were positive in a proportion similar to that of adult LE patients (9). Antiocardiolipin antibodies were present in only 25% of the patients.…”

Section: Discussionmentioning

confidence: 95%

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Discoid Lupus Erythematosus in Children—A Retrospective Study of 34 Patients

Sampaio

Oliveira

Machado

et al. 2008

Pediatric Dermatology

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Discoid lupus erythematosus is much less frequent and studied in children. We undertook a retrospective study of 34 children less than 16 years of age with this disease, seen over a period of 9 years. A female predominance of 2:1 was found. An association between discoid lupus erythematosus and systemic lupus erythematosus was observed in 23.5% of patients, a higher proportion compared to adult discoid lupus erythematosus. Disseminated lesions were much more frequent in patients with criteria for systemic lupus erythematosus (87.5% vs 34%), suggesting that it could be associated with a worse prognosis. Histologic findings were similar to those observed in adult discoid lupus erythematosus.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Discoid Lupus Erythematosus in Children—A Retrospective Study of 34 Patients

Sampaio

Oliveira

Machado

et al. 2008

Pediatric Dermatology

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“…A pesquisa do FAN é elemento indispensável em caso de suspeita clinica de doenças auto-imunes, em especial do grupo das colagenoses. Sua presença isolada não tem significado patológico, embora tenha um valor preditivo de maior possibilidade de o indivíduo desenvolver uma colagenose ao longo dos anos 9 .…”

Section: Discussionunclassified

Calcinose cutânea distrófica em adolescente: relato de caso

Ferrara

Souza

Alvarenga

et al. 2012

Rev. Med. (São Paulo)

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Calcinose cutânea é a precipitação de cristais de cálcio na pele. Pode ser dividida em quatro categorias: distrófica, metastática, iatrogênica e idiopática. A forma distrófica é a mais comum, com níveis séricos normais de cálcio e de fósforo. Relatamos caso de calcinose cutânea distrófica localizada e assintomática no joelho direito de um adolescente. Os exames clínico e laboratorias revelaram telangectasias periungueais e fator antinuclear positivo (títulomaior que 1/1280 de padrão nucleolar), o que sugere a associação da calcinose cutânea com uma colagenose

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“…Após a escolha do tema foi realizada uma busca isso, um FAN positivo é insuficiente para a confirmação de um diagnóstico 8,13 .…”

Section: Methodsunclassified

Main Serological Markers of Systemic Rheumatic Autoimmune Diseases

Souza¹,

Carneiro²,

Passos³

2017

EVS

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Resumo: doenças reumáticas autoimunes sistêmicas são doenças inflamatórias crônicas complexas, geralmente com comprometimento das articulações, acompanhado de manifestações sistêmicas. O presente estudo trata-se de uma revisão bibliográfica sobre os principais marcadores sorológicos utilizados no rastreio dessas doenças. A avaliação da presença de autoanticorpos constitui parte essencial no diagnóstico inicial de doenças autoimunes. A produção desses anticorpos ocorre através de resposta imune humoral contra antígenos próprios, e estão frequentemente presentes no soro de pacientes diagnosticados com doença autoimune. Cada anticorpo tem função e especificidade diferentes, e isso influencia diretamente na manifestação e curso da doença. Os principais marcadores detectados em reumatologia têm ação antinuclear, pró-trombótica e inflamatória, por isso, dependendo da complexidade da doença, vários marcadores podem ser encontrados, auxiliando tanto no diagnóstico quanto no prognóstico. Palavras-chave: Autoanticorpos. Anticorpos antinucleares. Marcadores sorológicos. Doenças reumáticas autoimunes.Abstract: systemic rheumatic autoimmune diseases are complex chronic inflammatory disorders, generally with impairment of joins and systemic manifestations. This study is a literature review about the main serologic markers used in the screening of these illnesses. The assessment of the presence of autoantibodies is an essential component in the initial diagnosis of autoimmune diseases. The production of these antibodies occurs via humoral immune response against self-antigens, and these antibodies are often present in the serum of patients diagnosed with autoimmune illness. Each antibody has a different function and specificity and this is directly associated with clinic manifestations and disease course. The main markers detected in rheumatology have antinuclear, prothrombotic and inflammatory action; therefore depending on the complexity of the illness, several markers can be identified, assisting both in diagnosis and prognosis disease.

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Fator antinúcleo na dermatologia

Cited by 6 publications

References 37 publications

Discoid Lupus Erythematosus in Children—A Retrospective Study of 34 Patients

Discoid Lupus Erythematosus in Children—A Retrospective Study of 34 Patients

Calcinose cutânea distrófica em adolescente: relato de caso

Main Serological Markers of Systemic Rheumatic Autoimmune Diseases

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