Clinical usefulness of endometrial screening by ultrasound in asymptomatic postmenopausal women

Gambacciani, M.

doi:10.1016/s0378-5122(03)00388-8

Cited by 10 publications

(16 citation statements)

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“…These results, although on a smaller scale compared with previous studies of Ribeiro and Gambacciani, are consistent with relatively rare findings of significant pathology in asymptomatic postmenopausal women with ET. Combining data from Ribeiro and Gambacciani for women who met the inclusion criteria for this study with the present data set gathered here, a patient pool can be generated.…”

Section: Resultssupporting

confidence: 90%

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Risks and benefits of hysteroscopy and endometrial sampling as a standard procedure for assessing serendipitous findings of endometrial thickening in postmenopausal women

Weaver

2014

Aust NZ J Obst Gynaeco

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A retrospective study was undertaken of 35 asymptomatic postmenopausal women undergoing hysteroscopy, dilatation and curettage (H D&C) for an incidental finding of thickened endometrium to assess the rate of significant pathological findings, cost per finding and complication rate of any procedures performed. This study found one case of endometrial adenocarcinoma (1/35; 3%) at an estimated cost per significant finding of $507,116 with an estimated 11.6 complication events per finding.

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Section: Resultssupporting

confidence: 90%

“…Complications were not reported in the two comparable studies by Ribeiro and Gambacciani . However, Lev‐Sagie reported complications at 3.6% (3/82) when performing H D&C + polypectomy.…”

Section: Resultsmentioning

confidence: 84%

Risks and benefits of hysteroscopy and endometrial sampling as a standard procedure for assessing serendipitous findings of endometrial thickening in postmenopausal women

Weaver

2014

Aust NZ J Obst Gynaeco

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“…A retrospective review of postmenopausal women subjected to a hysteroscopy with particular attention to those with endometrial thickening as the indication, found that using TVS as a screening tool in asymptomatic postmenopausal women generated 93.2% false positive results. This again suggests that this is not a beneficial screening tool …”

Section: Screening For Endometrial Pathologymentioning

confidence: 98%

“…Endometrial thickness and endometrial sampling have also been proposed as possible screening modalities for endometrial cancer in asymptomatic women. There is a baseline incidence of a thickened endometrium (>4.5 mm) in postmenopausal women of up to 17%, while there is a low incidence of cancer <1% in an unselected population . However, an incidental finding of an endometrial thickness of >5 mm in an asymptomatic woman often triggers a referral to the gynaecologist.…”

Section: Screening For Endometrial Pathologymentioning

confidence: 99%

Endometrial pathology in the postmenopausal woman – an evidence based approach to management

Otify

Fuller

Ross

et al. 2014

The Obstetric & Gynaecologis

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This article outlines how to identify the symptoms and signs associated with endometrial pathology and how these correlate with the final diagnosis. The evidence for and against intervention in asymptomatic women with a coincidental finding of endometrial pathology is discussed. This article looks at how best to investigate symptomatic women on hormone replacement therapy (HRT) and selective estrogen receptor modulators (SERMs). Screening for endometrial pathology is discussed. Learning objectivesTo be able to identify risk factors associated with postmenopausal endometrial pathology, as well as symptoms and signs.To learn about the models of care for different endometrial pathology. To understand the contentious issues and the risk-benefit profile of different strategies for the management of asymptomatic women. Ethical issuesDoes an incidental finding of a thick endometrium in asymptomatic postmenopausal women warrant further investigation? Should asymptomatic women receiving HRT or SERMs be routinely screened and investigated?

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“…Guidelines have recommended a threshold of 5 mm for necessitating further assessment of endometrial pathology in women with postmenopausal bleeding . However, in postmenopausal women without symptoms, the necessity of transvaginal ultrasound screening and the cut‐off value of endometrial thickness are unclear . Moreover, the thickness of endometrium assessed by transvaginal ultrasound can indirectly reflect estrogen status in asymptomatic women, and the results of the present study suggest that asymptomatic thicker endometrium is significantly associated with an increased risk of breast mass.…”

Section: Discussionmentioning

confidence: 68%

A population‐based study of the relationship between endometrial thickness and prevalence of breast mass in postmenopausal women

Ran

et al. 2019

Intl J Gynecology & Obste

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Objectives To determine the relationship between endometrial thickness and the prevalence of breast mass in postmenopausal women. Methods The prevalence of breast mass was investigated in 6759 postmenopausal women (≥60 years) with different endometrial thicknesses who underwent breast and transvaginal ultrasonography from January 2015 to June 2017. Multivariable logistic regression analysis was used to obtain odds ratios and 95% confidence intervals for breast mass in postmenopausal women with increased endometrial thickness after adjusting for age, height, and body mass index. Results Compared with a baseline endometrial thickness of less than 3 mm, the prevalence of breast mass increased in patients with endometrial thickness ≥3–4.9 mm (OR 1.077; 95% CI, 0.868–1.338), ≥5–9.9 mm (OR 1.910; 95% CI, 1.189–3.067), and ≥10 mm (OR 3.546; 95% CI, 1.458–8.620) (Ptrend=0.0026). In subgroup analysis, correlations between endometrial thickness and prevalence of breast mass with malignant possibility (BI‐RADS ≥3) were similar and remained significant (Ptrend=0.035). Conclusion Postmenopausal women with endometrial thickness greater than or equal to 5 mm have a significantly increased prevalence of breast mass and breast mass with malignant possibility (BI‐RADS ≥3). Breast cancer screening for postmenopausal women with increased endometrial thickness should be given greater attention.

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Clinical usefulness of endometrial screening by ultrasound in asymptomatic postmenopausal women

Cited by 10 publications

References 0 publications

Risks and benefits of hysteroscopy and endometrial sampling as a standard procedure for assessing serendipitous findings of endometrial thickening in postmenopausal women

Risks and benefits of hysteroscopy and endometrial sampling as a standard procedure for assessing serendipitous findings of endometrial thickening in postmenopausal women

Endometrial pathology in the postmenopausal woman – an evidence based approach to management

A population‐based study of the relationship between endometrial thickness and prevalence of breast mass in postmenopausal women

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