Clinical trial on standardised celandine extract in patients with functional epigastric complaints: results of a placebo-controlled double-blind trial

Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment

“…These studies evidenced a statistically significant improvement in patients treated with Greater celandine (Ritter et al, 1993;Niederau and Göpfert, 1999).…”

Chelidonium majus crude extract inhibits migration and induces cell cycle arrest and apoptosis in tumor cell lines

“…A number of pharmacological properties, e.g. spasmolitic (Hiller et al, 1998), anti-inflammatory (Lee et al, 2007), antioxidant (Jakovljević et al, 2013), antiulcer (Khayyal et al, 2001), antibacterial (Zuo et al, 2008), antiviral (Gerencer et al, 2006), immunomodulatory (Chung et al, 2004;Song et al, 2002) and antitumor (Aljuraisy et al, 2012;Mahmoud et al 2013) have been reviewed and supported by clinical data (Knöpfel, 1991;Ritter et al, 1993). By virtue of these properties C. majus is widely used in alternative medicine to treat liver diseases, gastric ulcer and spasm, oral infections, rheumatic diseases, tuberculosis and jaundice (Abu, 1956;Amirdowlat, 1990;Mills and Bone, 2000;Pelagić, 1893;Zadorozhnyj, 1990).…”

Herbal medicinal products for non‐ulcer dyspepsia

“…Ritter et al conducted a 6-week, placebo-controlled, double-blind, randomized trial using a standardized celandine extract in 60 patients with functional epigastric complaints and cramp-like pains in the region of the biliary and gastrointestinal tracts. 22 After 6 weeks of treatment, patients treated with the celandine extract reported fewer gastrointestinal symptoms compared with the placebo group (P ¼ 0.003). The symptoms that showed most improvement were stomach pains, bilious complaints, flatulence, nausea and sensation of fullness.…”