Clinical Studies of Buspirone

Schuckit, Marc A.

doi:10.1159/000284132

Cited by 54 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all cases almost no changes after buspi rone intake were found. It is suggested that the commonly reported cognitive deterioration of diazepam is due to its hypnotic and sedative actions [27], which is in line with others [21,22,[24][25][26]30]. In short, it is proposed here that the effects of diazepam on saccadic eye movements are due to its sedative and hypnotic properties.…”

Section: Discussionsupporting

confidence: 75%

“…Buspirone lacks the hypnotic and sedative properties of the benzodiazepines. It does not influence vigilance, while memory impairments and changes in motor per formance are minimal [24][25][26][27]. The aim of the present experiment is to establish and compare the influence of the two anxiolytic drugs diazepam and buspirone on the disengagement of attention, measured by differences in SRT in the gap and overlap conditions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Diazepam and Buspirone on Reaction Time of Saccadic Eye Movements

Fąfrowicz¹,

Unrug

Marek³

et al. 1995

Neuropsychobiology

View full text Add to dashboard Cite

Effects of the anxiolytic drugs diazepam and buspirone were studied on the reaction time of saccadic eye movements. The study was performed with 8 healthy volunteers in a double-blind, placebo-controlled way. The purpose was to investigate the putative drug effects on the first step of an attention shifting task: the disengagement of attention. Saccadic reaction time was measured in two conditions: the ‘gap’ and the ‘overlap’ condition. In the first condition a delay is present between the offset of a fixation spot and the onset of a target, while in the second condition the offset of the spot is overlapped by the onset of the target. Clear differences in saccadic reaction time in the expected direction were found between the two conditions, with longer reaction times of saccadic eye movements in the overlap condition. The nonsedative anxiolytic buspirone in a dose of 5 mg had no significant effects on saccadic reaction times, while clear effects of diazepam in a dose of 5 mg were established. Diazepam slowed down saccadic reaction times, reduced the number of fast sac-cades and facilitated the number of slow saccades. However, the effects induced by this drug were identical for the two conditions. The latter result implies that the disengagement of attention is not selectively disrupted by diazepam. Perhaps, the action of diazepam is expressed in other attention factors, such as in shifting attention or in the reengagement of attention. A slowing down of these processes by the vigilance-lowering properties of diazepam might be the cause of the prolonged latencies. The increased latencies of saccadic eye movements induced by a low dose of diazepam may have practical implications.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Effects of Diazepam and Buspirone on Reaction Time of Saccadic Eye Movements

Fąfrowicz¹,

Unrug

Marek³

et al. 1995

Neuropsychobiology

View full text Add to dashboard Cite

show abstract

“…Advantages of buspirone over the benzodiazepine class of anxiolytics include its favorable safety profile for long term use, lack of abuse and dependence potential, and lack of withdrawal reactions [Shuckit, 1984;Lader, 1991;Pecknold, 1997]. In addition, buspirone maintains cognitive functioning, psychomotor skills, and alertness, producing no more sedation than placebo [Lader, 1982;Cohn and Wilcox, 1986;Mattila et al, 1986].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the safety and tolerability of two dose regimens of buspirone in patients with persistent anxiety

et al. 1999

View full text Add to dashboard Cite

“…Buspirone (Buspar) is one of the relatively new anxio lytics, not belonging to the family of the benzodiazepines [10], It is currently used in anxiety-related disorders [11][12][13]. It is of interest that buspirone lacks hypnotic and sed ative properties and does not influence vigilance [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Cognition and Vigilance: Differential Effects of Diazepam and Buspirone on Memory and Psychomotor Performance

1992

View full text Add to dashboard Cite

Effects of a single dose of the anxiolytic buspirone (15 mg) on memory and psychomotor performance were studied in healthy volunteers and compared to those of the classic benzodiazepine anxiolytic diazepam (15 mg). The study was performed in a double-blind, placebo-controlled way. Three groups of 12 subjects were exposed to an extended test battery before and after intake of drug or placebo. Next to this, an evaluation session took place 1 week later. Immediately after intake, diazepam exerted major effects on memory, impaired psychomotor performance and decreased alterness. In particular, long-term memory had deteriorated, which was interpreted as anterograde amnesia. One week later, more items were recalled from the predrug session compared to the number of items from the postdrug session; this was interpreted as retrograde facilitation. After intake of buspirone, there were no effects of altertness and vigilance, on psychomotor performance and on memory. One week later, a small memory decrement was noticed for verbal material, which was considered as a sign of anterograde amnesia. These results indicate that effects of anxiolytics on memory can be more easily demonstrated 1 week later than immediately after drug intake and, furthermore, that the disruptive effects of diazepam outweigh the small effects of buspirone. Finally, it was established that the effects of diazepam on cognition might be mediated by its effects on alertness and vigilance and that cognitive effects are not related to the anxiolytic properties of the drug.

show abstract

Clinical Studies of Buspirone

Cited by 54 publications

References 9 publications

Effects of Diazepam and Buspirone on Reaction Time of Saccadic Eye Movements

Effects of Diazepam and Buspirone on Reaction Time of Saccadic Eye Movements

Meta-analysis of the safety and tolerability of two dose regimens of buspirone in patients with persistent anxiety

Cognition and Vigilance: Differential Effects of Diazepam and Buspirone on Memory and Psychomotor Performance

Contact Info

Product

Resources

About