Meta-analysis of the safety and tolerability of two dose regimens of buspirone in patients with persistent anxiety

Sramek, John J.; Hong, Walter W.; Hamid, Suha; Nape, Barbara; Cutler, Neal R.

doi:10.1002/(sici)1520-6394(1999)9:3<131::aid-da5>3.0.co;2-h

Cited by 181 publications

(5 citation statements)

References 17 publications

(19 reference statements)

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“…A global improvement of the Hamilton anxiety rating scale (HAM-A) in the patients with buspirone was observed. The results of these two meta-analyses are different in comparison with more recent studies Sramek et al, 1999) and it can be concluded that buspirone given for 4 to 8 weeks in GAD-treated patients induced an anxiolytic effect depending on the evaluation criterion. The onset of action began after 2 weeks, the drug effect was mainly based on psychic anxiety.…”

Section: Generalised Anxiety Disordercontrasting

confidence: 63%

Pharmacotherapy of anxious disorders

Bourin

Lambert²

2002

Human Psychopharmacology

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The present paper is a review of the treatment of anxious disorders by the current pharmaceutical medications; a short epidemiological survey is given for anxious disorders including: general anxiety disorder, panic disorder, obsessive compulsive disorder, social anxiety and post-traumatic stress disorder. For all these disorders there are proposals of treatment built on literature data mainly on meta-analysis as well on personal experience.

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Section: Generalised Anxiety Disordercontrasting

confidence: 63%

Pharmacotherapy of anxious disorders

Bourin

Lambert²

2002

Human Psychopharmacology

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“…A common functional variation (C(-1019)G) in the human 5-HT 1A gene (HTR 1A ) is associated with increased 5-HT 1A autoreceptor expression and decreased threat-related amygdala reactivity (Fakra et al, 2009). Finally, psychotropic drugs such as buspirone and vilazodone with 5-HT 1A receptor binding properties have been found to be clinically useful for anxiety symptoms (Akimova, Lanzenberger, & Kasper, 2009; Gommoll et al, 2015; Sramek, Hong, Hamid, Nape, & Cutler, 1999).…”

Section: Introductionmentioning

confidence: 99%

Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study

Selvaraj

Walker

Arnone

et al. 2017

Neuropsychopharmacol.

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A subset of patients started on a selective serotonin reuptake inhibitor (SSRI) initially experience increased anxiety, which can lead to early discontinuation before therapeutic effects are manifest. The neural basis of this early SSRI effect is not known. Presynaptic dorsal raphe neuron (DRN) 5-HT1A receptors are known to play a critical role in affect processing. Thus we investigated the effect of acute citalopram on emotional processing and the relationship between DRN 5-HT1A receptor availability and amygdala reactivity. Thirteen (mean age 48±9 years) healthy male subjects received either a saline or citalopram infusion intravenously (10 mg over 30 minutes) on separate occasions in a single-blind, random order, cross-over design. On each occasion, participants underwent a block design face-emotion processing task during fMRI known to activate the amygdala. Ten subjects also completed a positron emission tomography (PET) scan to quantify DRN 5-HT1A availability using [11C]CUMI-101.Citalopram infusion when compared to saline resulted in a significantly increased bilateral amygdala responses to fearful vs. neutral faces (Left p=0.025; Right p=0.038 FWE-corrected). DRN [11C]CUMI-101availability significantly positively correlated with the effect of citalopram on the left amygdala response to fearful faces (Z=2.51, p=0.027) and right amygdala response to happy faces (Z=2.33, p=0.032). Our findings indicate that the initial effect of SSRI treatment is to alter processing of aversive stimuli, and that this is linked to DRN 5-HT1A receptors in line with evidence that 5-HT1A receptors have a role in mediating emotional processing.

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“…The safety results from two comparisons of buspirone 15 mg bd and buspirone 10 mg tds in patients with persistent anxiety have been subjected to meta-analysis [23]. The incidences of adverse events were similar, except for a significantly higher incidence of bouts of palpitation in patients taking buspirone bd (5%) compared with tds (1%).…”

Section: Systematic Reviewsmentioning

confidence: 99%

Buspirone

2016

Meyler's Side Effects of Drugs

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Meta-analysis of the safety and tolerability of two dose regimens of buspirone in patients with persistent anxiety

Cited by 181 publications

References 17 publications

Pharmacotherapy of anxious disorders

Pharmacotherapy of anxious disorders

Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study

Buspirone

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