Clinical strategies for treating pediatric cancer during the outbreak of 2019 novel coronavirus infection

Yang, Chao; Li, ChangChun; Wang, Shan

doi:10.1002/pbc.28248

Cited by 31 publications

(50 citation statements)

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“…Paradoxically, the main risk factor, which exponentially usually increases infection risks, might be protective on this regard. As a matter of fact, immunocompromised patients usually experience social isolation per se, therefore they might have been early spared since the earliest phases of the outbreak [12,13].…”

Section: Discussionmentioning

confidence: 99%

Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati

Balduzzi

Brivio

Rovelli

et al. 2020

Bone Marrow Transplant

120

139

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Italy is the second exposed country worldwide, after China, and Lombardia is the most affected region in Italy, with more than half of the national cases, with 13% of whom being healthcare professionals. The Clinica Pediatrica Università degli Studi di Milano Bicocca is a general pediatric and hematology oncology and transplant center embedded within the designated COVID-19 general Hospital San Gerardo in Monza, located in Lombardia, Italy. Preventive and control measures specifically undertaken to cope with the emergency within hemato-oncology, transplant, and outpatient unit in the pediatric department have been described. Preliminary COVID-19 experiences with the first Italian pediatric hemato-oncology patients are reported. The few available data regarding pediatrics and specifically hemato-oncological patients are discussed. The purpose of this report is to share pediatric hemato-oncology issues encountered in the first few weeks of the COVID-19 outbreak in Italy and to alert healthcare professionals worldwide to be prepared accordingly. Background-the SARS-CoV-2 outbreak in ItalyAs of March 18, at 4 p.m., according to the WHO dashboard, updated every 15 min, 194,029 cases of SARS CoV-2 infection in 164 countries have been confirmed worldwide, yielding 7873 deaths [1].On the same date, the Istituto Superiore di Sanità (ISS) reported 31,506 cases in Italy, the second exposed country in the worldwide list, after China. Healthcare professionals constitute 9% of the confirmed case. Overall 2503 deaths have been reported in Italy. Cases are defined by positive molecular tests analyzed in specific regional laboratories, designated by the health authority. In the cases reported above, symptoms were absent in 6%, mild in 55%, unspecified in 10%, severe in 25%, life-threatening in 4%. Criteria for performing swabs varied overtime, with most symptomatic cases and contacts of confirmed cases being included in the first weeks and mainly severe cases being the majority of the tested cases more recently. 13% of the positive cases have been admitted in hospitals so far and 12% of them have been assisted in intensive care units (ICU) [2].Lombardia is, by far, the most affected region in Italy, with more than half of the national cases (median age 65 years, range 0-101), with 13% of whom being healthcare professionals. Most cases are concentrated in the Bergamo area [3].

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Section: Discussionmentioning

confidence: 99%

Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati

Balduzzi

Brivio

Rovelli

et al. 2020

Bone Marrow Transplant

120

139

View full text Add to dashboard Cite

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“…Recommendations for the management of sick children who are diagnosed with COVID-19 are appearing quickly. 44 While death is extremely rare in children with COVID-19, it can occur in patients who are already very sick.…”

Section: Novel Coronavirus Pneumonia Emergency Response Epidemiologymentioning

confidence: 99%

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

2020

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Aim:The coronavirus disease 2019 pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare. Methods:A systematic literature review was carried out to identify papers on COVID-19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using the MEDLINE and Embase databases between January 1 and March 18, 2020. Results:The search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%-5% of diagnosed COVID-19 cases, they often have milder disease than adults and deaths have been extremely rare.Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia.Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID-19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. Conclusions:The coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.

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“…However, patients receiving intensive chemotherapy, severely immunosuppressed, or GVHD may be at a higher risk of morbidity and even mortality. During this pandemic, concern exists whether children with cancer may present late for diagnosis or not receive appropriate oncological treatment 25,26 . In our cohort, half of the patients interrupted their anticancer treatment due to the infection.…”

Section: Characteristics Nmentioning

confidence: 99%

Initial report on Spanish pediatric oncologic, hematologic, and post stem cell transplantation patients during SARS‐CoV‐2 pandemic

Faura

Rives

Lassaletta

et al. 2020

Pediatric Blood & Cancer

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Clinical strategies for treating pediatric cancer during the outbreak of 2019 novel coronavirus infection

Cited by 31 publications

References 1 publication

Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati

Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

Initial report on Spanish pediatric oncologic, hematologic, and post stem cell transplantation patients during SARS‐CoV‐2 pandemic

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