Initial report on Spanish pediatric oncologic, hematologic, and post stem cell transplantation patients during SARS‐CoV‐2 pandemic

Faura, Anna; Rives, Susana; Lassaletta, Álvaro; Sebastián, Elena; Madero, Luís; Huerta, Jorge; García‐Morín, Marina; Martínez, A. Pérez; Sisinni, Luisa; Astigarraga, Itziar; Velasco, Pablo; Gros, Luis; Moreno, Lucas; Carboné, Ana; Rodríguez‐Vigil, Carmen; Riesco, Susana; Mendoza, M. C.; Macias, Elena Garcia; Trabazo, María Rosaura Leis; Torrent, Montse; Badell, Isabel; Fuster, José Luís; Domínguez‐Pinilla, Nerea; Ribelles, Antonio Juan; Pérez‐Alonso, Vanesa; Sanmartín, M. Fernández; Baragaño, Marta; Gorostegui, Maite; Perez-Jaume, Sara; Fernández‐Teijeiro, Ana; Madrid, Andrés Morales La; Dapena, José Luís

doi:10.1002/pbc.28557

Cited by 36 publications

(51 citation statements)

References 25 publications

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“…7 The median age of our patients was younger than most reports in the literature (6 vs 11 years). [7][8][9]12 There was a male preponderance (64.7%) similar to the gender distribution in the general adult and pediatric population. 4,17,18 Most of our cases (60.8%) had hematological malignancies, similar to some other series.…”

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confidence: 56%

“…1,2 Although children seem to be at a lower risk for COVID-19 than adults, [3][4][5] data specifically addressing children with cancer are limited. [6][7][8][9][10][11][12] We conducted a retrospective, multicenter, cross-sectional study on behalf of the Turkish Pediatric Hematology Society (TPHD) and Turkish Pediatric Oncology Group (TPOG) Society to analyze the characteristics of COVID-19 in all patients with cancer and stem cell transplant (SCT) recipients in all centers in Turkey, during March 11-May 31, 2020. Approval for the study was obtained by Turkish Ministry of Health (MoH),…”

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confidence: 99%

“…4,17,18 Most of our cases (60.8%) had hematological malignancies, similar to some other series. 9,12 COVID-19 causes multiple organ involvement due to widespread distribution of angiotensin-converting enzyme-2, the functional receptor for SARS-CoV-2 in multiple organs. 11,19 Shekerdemian et al 20 reported that 73% of the pediatric cases were admitted with respiratory findings, while 25% of cases presented with other system findings such as gastrointestinal and neurological systems.…”

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confidence: 99%

“…It is hard to speculate which drugs are best for the disease as the search for the "standard of care" drugs are still under debate globally, national and international guides for management are frequently being revised. 6,7,[10][11][12]20,21 The evaluation and sharing of national data, as in our study that includes all children with cancer/SCT and COVID-19 within a time frame, without any selection bias, and accumulation of international data shall lead to a better understanding of the disease, treatment and risk factors to guide health care professionals.…”

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confidence: 99%

See 3 more Smart Citations

COVID‐19 infection in children with cancer and stem cell transplant recipients in Turkey: A nationwide study

Kebudi

Kurucu

Tuğcu

et al. 2021

Pediatric Blood & Cancer

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confidence: 56%

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confidence: 99%

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confidence: 99%

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confidence: 99%

See 2 more Smart Citations

COVID‐19 infection in children with cancer and stem cell transplant recipients in Turkey: A nationwide study

Kebudi

Kurucu

Tuğcu

et al. 2021

Pediatric Blood & Cancer

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“…Regarding the comparative analysis between tumor types and the need for hospitalization, no differences were found in the three included studies. This is because in most cases, it coincided with the period immediately after chemotherapy, and the information on the deferral of the sessions is insufficient for analysis ( 51 – 53 ). The same scenario is observed in the need for intensive care in the studies showing the causes, which in addition coincided with febrile neutropenia events.…”

Section: Discussionmentioning

confidence: 99%

Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis

et al. 2021

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BackgroundThe pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected all age groups, including the pediatric population, in 3–5% of all cases. We performed a meta-analysis to understand the survival and associated complications in pediatric cancer patients as well as their hospitalization, intensive care, and ventilation care (supplemental oxygen/endotracheal intubation) needs.MethodsA systematic search was performed using MEDLINE, TRIP Database, International Clinical Trials Registry Platform (WHO), The Cochrane Library, Wiley, LILACS, and Google Scholar. Additionally, a search using the snowball method was performed in Nature, New England Journal of Medicine, Science, JAMA, ELSEVIER editorial, Oxford University Press, The Lancet, and MedRxiv. Searches were conducted until July 18, 2020. A total of 191 cancer patients with coronavirus disease 2019 (COVID-19) were integrated from 15 eligible studies. In a sub-analysis, patients were stratified into two groups: hematological cancer and solid tumors. Outcome measures were overall survival, risk of hospitalized or needing intensive care, and need for ventilatory support in any modality. The random effects statistical analysis was performed with Cochran’s chi square test. The odds ratio (OR) and heterogeneity were calculated using the I2 test.ResultsThe overall survival was 99.4%. There were no statistically significant differences in the risk of hospitalization between hematological malignancies and solid tumors (95% confidence interval [CI] 0.48–18.3; OR = 2.94). The risk of being admitted to the intensive care unit was also not different between hematological malignancies and other tumors (95% CI 0.35–5.81; OR = 1.42). No differences were found for the need of ventilatory support (95% CI 0.14–3.35; OR = 0.68). Although all the studies were cross-sectional, the mortality of these patients was 0.6% at the time of analysis.ConclusionsIn the analyzed literature, survival in the studied group of patients with COVID-19 was very high. Suffering from hematological neoplasia or other solid tumors and COVID-19 was not a risk factor in children with cancer for the analyzed outcomes.

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COVID‐19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta‐analysis

Lim

Khan

Karpha

et al. 2022

eJHaem

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Up‐to‐date information on coronavirus disease 2019 (COVID‐19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID‐19 mitigation strategies. We performed a meta‐analysis to address this knowledge gap. All studies with at least five patients who reported COVID‐19‐related deaths in HCT recipients were included. The primary outcome was COVID‐19‐related death. Secondary outcomes were COVID‐19‐related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID‐19‐related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%–24%), while MV and ITU admission rates were 14% (95% CI 11%–17%) and 18% (95% CI 14%–22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID‐19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09–3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38–3.20) or in the context of active graft‐versus‐host disease (RR 2.38, 95% CI 1.10–5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID‐19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID‐19 outcomes.

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Initial report on Spanish pediatric oncologic, hematologic, and post stem cell transplantation patients during SARS‐CoV‐2 pandemic

Cited by 36 publications

References 25 publications

COVID‐19 infection in children with cancer and stem cell transplant recipients in Turkey: A nationwide study

COVID‐19 infection in children with cancer and stem cell transplant recipients in Turkey: A nationwide study

Survival and Complications in Pediatric Patients With Cancer and COVID-19: A Meta-Analysis

COVID‐19 outcomes in haematopoietic cell transplant recipients: A systematic review and meta‐analysis

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