Clinical significance of biological differences between cavitated and solid form of squamous cell lung cancer

Gasińska, Anna; Kołodziejski, L; Niemiec, Joanna; Dyczek, Sonia

doi:10.1016/j.lungcan.2005.01.007

Cited by 23 publications

(14 citation statements)

References 24 publications

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“…The process of cavitation in lung tumors has been associated with a poor prognosis,30 and more than 80% of cavity-forming pulmonary tumors associated with epidermal growth factor receptor overexpression exhibit rapid growth 31. Non-small cell carcinoma, especially squamous cell carcinoma, is the most common histologic type of cavity forming tumor, whereas small cell carcinoma has never been reported to cavitate 32. Rarely, cavitation or multiloculated cystic changes have been reported in lung adenocarcinoma 33.…”

Section: Cavitary Pulmonary Lesionsmentioning

confidence: 99%

Pathologic Review of Cystic and Cavitary Lung Diseases

Kim

Han

2012

Korean J Pathol

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Pulmonary cystic and cavitary lesions caused by diverse etiologies are commonly encountered in chest imaging. The terms "cyst" and "cavity" are used to describe air-filled regions in the center of a nodule or consolidation of the lung. To date, only radiologic aspects of these lesions have been addressed. The morphologies of pulmonary cystic and cavitary lesions exhibit a broad spectrum, ranging from benign to malignant pulmonary diseases of acquired or congenital origin, including variable infectious diseases. In this review, we summarized the differential diagnosis of pathological entities to provide pathologists and radiologists with an overview of the diseases most commonly associated with pulmonary cystic and cavitary lesions in adults and children. The results showed slightly different patterns in the distribution of the diseases in the two groups. The most common causes of cavitary lesions include malignancy and infection in adults, and congenital malformation in children. Therefore, identification of pathologic entities correlating with the radiologic findings, clinical course, and location of the lesion is important in the evaluation of cystic and cavitary lung lesions in order to avoid unnecessary surgical procedures or delayed treatment.

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Section: Cavitary Pulmonary Lesionsmentioning

confidence: 99%

Pathologic Review of Cystic and Cavitary Lung Diseases

Kim

Han

2012

Korean J Pathol

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“…This suggests that RECIST 1.1 is best for evaluating patients with baseline cavitation, while mRECIST may be a more accurate method to predict PFS in patients who develop post‐therapeutic cavitation. Cavitation at baseline most often represents a rapidly expanding tumor that outgrows its blood supply and develops central necrosis, but does not represent tumor response to treatment compared with post‐therapeutic cavitation, which signifies a treatment response 17. Recent studies have generally recommended that mRECIST should be used in lung cancer with cavitation, but only applies to cases that have developed cavitation after treatment with anti‐angiogenic agents.…”

Section: Discussionmentioning

confidence: 99%

Significance of different response evaluation criteria in predicting progression‐free survival of lung cancer with certain imaging characteristics

et al. 2016

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BackgroundCertain radiographic signs of a treatment response, such as cavitation, changes in density, or tumor change along a short axis, are not considered by Response Evaluation Criteria in Solid Tumors (RECIST). This study evaluates what additional prognostic information can be obtained by including these criteria in tumor assessment.MethodsData of 105 patients were included. Tumor cavitation was observed in 51 patients at baseline. An additional 23 patients developed tumor cavitation during treatment. A change in tumor density was the only radiographic treatment response observed in 22 patients. The only measureable treatment response in nine patients was a decrease along the short axis size of the tumor. Tumor response was assessed using various criteria.ResultsIn patients with basic tumor cavitation, RECIST1.1 scores accurately predicted differences in progression‐free survival (PFS; P = 0.076) while modified (m) RECIST did not (P = 0.550). mRECIST detected a significant difference between PFS in patients with post‐therapeutic cavitation with different responses, but no significant difference using RECIST1.1 (P = 0.004 vs. P = 0.477). In patients with only tumor density changes, there was no significant difference in PFS when either RECIST1.1 or density criteria were used (P = 0.419). In patients with a change in size along the tumor's short axis, short axis criteria could predict significant difference in PFS (P = 0.004).Conclusions RECIST1.1 provides the best assessment of tumor response and prediction of PFS in patients with basic tumor cavitation. mRECIST provides better PFS prognostic information in patients with post‐therapeutic cavitation. Short axis criteria provides better PFS prognostic information in patients with changes in the short axis of tumor diameter. Changes in tumor density were not a useful prognostic sign.

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“…pared del tórax, situación extremadamente infrecuente (6). Las lesiones cavitadas tumorales pueden ser interpretadas como abscesos pulmonares y así retardar el diagnóstico durante el tratamiento de los mismos; se sabe además que en un 5 al 15% de los abscesos pulmonares se encuentra cáncer pulmonar subyacente que predispone a la infección (7), sin tener en cuenta los demás diagnósticos diferenciales como la tuberculosis pulmonar y las infecciones por Nocardia y Actinomicetos.…”

Section: Aunclassified

Tumor escamocelular pulmonar bien diferenciado que se presenta con cavitación, infiltración de reja costal y fístula a pared del tórax

Medina

Sua

Fernández

2016

rev. colomb. neumol.

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El cáncer escamocelular de pulmón es una patología de prevalencia alta en el mundo, en especial en personas fumadoras. Típicamente afecta la vía respiratoria de conducción y la variedad papilar tiende a invadir los bronquios. Los síntomas más frecuentes son causados por el efecto mecánico en la vía aérea inferior e incluyen tos, hemoptisis y neumonías recurrentes. Se expone el caso de un paciente con un tumor escamocelular bien diferenciado de pulmón con comportamiento atípico y agresivo, compromiso de la vía aérea, la pleura, la reja costal y los tejidos blandos del tórax hasta la piel; además de sus manifestaciones clínicas, estudios diagnósticos y la revisión de la literatura al respecto. El carcinoma escamocelular pulmonar forma parte de los tumores de célu-las no pequeñas del pulmón. Es una neoplasia maligna típicamente productora de queratina que se diferencia por la histología y los estudios de inmunohistoquímica tiene una prevalencia mayor en los fumadores o exfumadores los cuales representan el 90% de los casos, el diagnóstico oportuno mejora la supervivencia y calidad de vida de los pacientes afectados. En este oportunidad presentamos un caso con comportamiento atipico que nos enseña a incluirlo en el diagnóstico diferencial de lesiones que comprometen la pared del tórax.Palabras clave: pulmón, invasión, escamo-celular, pared torácica. AbstractSquamous cell cancer of the lung is a common condition at the worldwide level, especially in smokers. It typically affects the conduction airway, and the papillary variety tends to invade the bronchi. The most common symptoms are caused by the mechanical effect on the lower airway, and include cough, hemoptysis, and recurrent pneumonia. We present the case of a patient with a well differentiated squamous cell tumor whose behavior was atypical and aggressive, with involvement of the airway, the pleura, the rib cage, and the soft tissues of the chest up to the skin. We also describe its clinical manifestations, diagnostic studies, and review the literature. Squamous cell carcinoma of the lung is one of the non-small-cell lung carcinomas. It is a malignant neoplasm that typically produces keratin, and is discriminated by histological and immunohistochemical studies. Its prevalence is higher among smokers and ex-smokers, who represent 90% of cases. Timely diagnosis improves the survival and quality of life of affected patients. In this article we present a case with atypical behavior; it teaches us to include this condition in the differential diagnosis of injuries compromising the chest wall.

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Clinical significance of biological differences between cavitated and solid form of squamous cell lung cancer

Cited by 23 publications

References 24 publications

Pathologic Review of Cystic and Cavitary Lung Diseases

Pathologic Review of Cystic and Cavitary Lung Diseases

Significance of different response evaluation criteria in predicting progression‐free survival of lung cancer with certain imaging characteristics

Tumor escamocelular pulmonar bien diferenciado que se presenta con cavitación, infiltración de reja costal y fístula a pared del tórax

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