Clinical Significance of Atypical Glandular Cells of Undetermined Significance

Chhieng, David C.; Elgert, Paul; Cangiarella, Joan; Cohen, Jean‐Marc

doi:10.1159/000328530

Cited by 67 publications

(82 citation statements)

References 13 publications

(15 reference statements)

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“…Most laboratories report an AGUS rate Ͻ 1%. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The AGUS rate of 0.56% observed among the general patient population in our laboratory was in agreement with the current literature. Few studies have investigated the incidence of atypical endometrial cells in cervicovaginal smears.…”

Section: Discussionsupporting

confidence: 88%

“…3 In the current study, the majority of significant uterine lesions (79%) were endometrial in origin after a diagnosis of atypical endometrial cells. This may be explained by the fact that patients with atypical endometrial cells tended to be older (average age, 53 years vs. 45 years in a previous study 3 ) and were more likely to be postmenopausal (55% vs. 40% in a previous study 3 ) compared with patients who were diagnosed with AGUS. Similar observations were made by other authors.…”

Section: Discussionmentioning

confidence: 49%

“…In patients with an otherwise negative initial histologic evaluation and persistent glandular atypia on repeat cervicovaginal smears, the clinician should consider more aggressive evaluation. 3,18,19 It cannot be overemphasized that communication between clinicians and cytopathologists must be established to convey the degree of concern about possible neoplasia for a cytologic interpretation of AGUS-EM.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Little is known about the clinical significance of AGUS, favor endometrial origin (AGUS-EM). In this retrospective study, we determined the rate of a diagnosis of AGUS-EM and the incidence of clinically significant lesions in women with this cytologic diagnosis on subsequent follow-up.…”

mentioning

confidence: 99%

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Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Chhieng

Elgert

Cohen

et al. 2001

Cancer

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Chhieng

Elgert

Cohen

et al. 2001

Cancer

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“…1 Before 2001, a spectrum of glandular cell abnormalities in cervical smears was grouped under atypical glandular cells of undetermined significance (AGUS) and defined as glandular cells exhibiting changes beyond reactive or reparative changes, but lacking unequivocal features of invasive adenocarcinoma. 2 The incidence and clinical significance of AGUS have been extensively reported, [3][4][5][6] however, studies reporting AGUS smears in pregnancy and postpartum period are very limited.…”

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confidence: 99%

Atypical Glandular Cells in Cervical Smear During Pregnancy and Postpartum Period

Tam¹

2005

Clinical Medicine & Research

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The 2001 Bethesda System defines atypical glandular cells (AGC) as glandular cell abnormalities that are distinct from adenocarcinoma or adenocarcinoma in situ. 1 Before 2001, a spectrum of glandular cell abnormalities in cervical smears was grouped under atypical glandular cells of undetermined significance (AGUS) and defined as glandular cells exhibiting changes beyond reactive or reparative changes, but lacking unequivocal features of invasive adenocarcinoma. 2 The incidence and clinical significance of AGUS have been extensively reported, 3-6 however, studies reporting AGUS smears in pregnancy and postpartum period are very limited.Chhieng and colleagues 7 have reported the largest number of AGUS smears in pregnancy and postpartum period (n=35). Among the 13,361 smears performed during the 3-year study period, this group reported a 0.26% incidence rate with a mean patient age of 29. Of the 35 patients with AGUS smears, 8 patients were lost to follow up, 17 were referred for colposcopy and biopsy, and 10 had repeated smears. For those who underwent colposcopy and biopsy, five patients had histologically proven cervical intraepithelial lesions. The others had benign pathologies including squamous cell metaplasia, endocervical or endometrial polyps, Arias-Stella reactions and microglandular hyperplasia. Two of the 10 patients had persistent abnormalities on repeated smears but their outcomes were not reported. The authors reported the incidence of significant pathology in this study as 29%. However, the incidence rate of significant pathology was calculated on the basis of the 17 cases referred for colposcopy and biopsy only, and did not include the patients being followed with repeated smears which would reduce the rate of significant pathology to less than 20%.Two other studies have been reported on pregnancy related AGUS, although these involved smaller numbers of patients. Michael and colleagues 8 reported 26 cases of AGUS during pregnancy or postpartum period, most of which were followed with repeated cervical smears after 3 to 6 months. Biopsies were performed in the postpartum period only if atypia persisted on repeat smears. Eight patients had colposcopy directed biopsies and only 2 patients were diagnosed with squamous cell intraepithelial lesions. Kim and colleagues 9 reported a large study of 326 patients: 21 were diagnosed with AGUS during pregnancy or within 8 weeks postpartum. Only one of the 21 patients had significant pathology showing carcinoma in situ, though the method of follow-up was not specified. From the studies described above, the incidence of

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Please! no ?AGUS? swamp

Selvaggi

1999

Diagn. Cytopathol.

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Clinical Significance of Atypical Glandular Cells of Undetermined Significance

Cited by 67 publications

References 13 publications

Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Atypical Glandular Cells in Cervical Smear During Pregnancy and Postpartum Period

Please! no ?AGUS? swamp

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