Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Chhieng, David C.; Elgert, Paul; Cohen, Jean‐Marc; Cangiarella, Joan

doi:10.1002/cncr.10139

Cited by 20 publications

(16 citation statements)

References 28 publications

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“…Chhieng et al 26 reported significant uterine lesions in women with atypical endometrial cells on cytology; the majority of which were endometrial in origin. Endometrial carcinoma was found in 47% of the cases on histologic follow-up and 24% of the cases showed complex atypical endometrial hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Glandular epithelial abnormalities on thinprep^® pap tests: Clinical and cytohistologic correlation

Selvaggi

2016

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

Glandular epithelial abnormalities on thinprep^® pap tests: Clinical and cytohistologic correlation

Selvaggi

2016

Diagnostic Cytopathology

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“…Chhieng et al [16], reported that AGUS (AGC) is highly correlated to malignant diseases (15.45%). Moreover, Seok et al [17], reported that invasive diseases were found in 50 subjects (57.4%) during histologic examination, among 87 subjects who were diagnosed with AGUS by Pap smear.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological significance of atypical glandular cells on Pap smear

et al. 2013

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ObjectiveTo investigate the clinical significance of atypical glandular cells (AGC) by analyzing the prevalence and histologic outcomes of patients with AGC according to Pap smear.MethodsThe medical records of 83 patients who were diagnosed AGC on Pap tests at the Pusan National University Hospital outpatient department and health care center from January 1998 to March 2006 were reviewed.ResultsThe prevalence of AGC was 55 of 54,160 (0.10%) and 28 of 54,160 (0.05%) for AGC-not otherwise specified (NOS) and neoplastic associated AGC, respectively. The histopathologic results of the AGC-NOS group (n=55) were as follows: low-grade squamous intraepithelial lesion, 7 (12.7%); high-grade squamous intraepithelial lesion, 4 (7.2%); adenocarcinoma of cervix, 3 (5.4%); endometrial carcinoma, 2 (3.6%); and other malignancies including 2 ovarian cancer cases and 1 breast cancer case, 3 (5.4%). The histopathologic results for the AGC-associated neoplastic group (n=28) were as follows: low-grade squamous intraepithelial lesion, 1 (3.5%); high-grade squamous intraepithelial lesion, 3 (10.7%); adenocarcinoma of cervix, 5 (17.8%); endometrial carcinoma, 4 (4.8%); and additional malignancies including 3 stomach cancer cases, 2 ovarian cancer cases, and 2 breast cancer cases; 7 (25%).ConclusionAGCs may represent a variety of benign and malignant lesions. AGC-associated neoplastic findings may be related to gynecological or extrauterine malignancies. Thus, when AGCs, especially neoplastic AGCs, are encountered, it is best to evaluate the cervix not only for typical maladies, but also for gynecological and non-gynecological malignancies.

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“…The data in the literature, however, are variable, and about one-third of cases with "atypical endometrial cells" have significant uterine lesions, with the majority being endometrial hyperplasia or endometrial adenocarcinoma. 27 Studies concerning the impact of LBC on AGUS/ AGC reporting yield controversial results. Some concluded an improved specificity and sensitivity by using LBC, 28 whereas others did not show any significant improvement.…”

Section: Time Interval Between Cytologic Diagnosis Of "Agc" and Detecmentioning

confidence: 99%

Follow-up Study of Atypical Glandular Cells in Gynecologic Cytology Using Conventional Pap Smears and Liquid-Based Preparations

Lee

Ng²

2008

Acta Cytologica

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Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Cited by 20 publications

References 28 publications

Glandular epithelial abnormalities on thinprep^® pap tests: Clinical and cytohistologic correlation

Glandular epithelial abnormalities on thinprep^® pap tests: Clinical and cytohistologic correlation

Clinicopathological significance of atypical glandular cells on Pap smear

Follow-up Study of Atypical Glandular Cells in Gynecologic Cytology Using Conventional Pap Smears and Liquid-Based Preparations

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Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin

Cited by 20 publications

References 28 publications

Glandular epithelial abnormalities on thinprep® pap tests: Clinical and cytohistologic correlation

Glandular epithelial abnormalities on thinprep® pap tests: Clinical and cytohistologic correlation

Clinicopathological significance of atypical glandular cells on Pap smear

Follow-up Study of Atypical Glandular Cells in Gynecologic Cytology Using Conventional Pap Smears and Liquid-Based Preparations

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Product

Resources

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Glandular epithelial abnormalities on thinprep^® pap tests: Clinical and cytohistologic correlation

Glandular epithelial abnormalities on thinprep^® pap tests: Clinical and cytohistologic correlation