Clinical Risk Factors for Proliferative Vitreoretinopathy

Cowley, Marianne; Conway, Brian; Campochiaro, Peter A.; Kaiser, Donald L.; Gaskin, Hugh

doi:10.1001/archopht.1989.01070020213027

Cited by 182 publications

(89 citation statements)

References 16 publications

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“…4,5 Several risk factors for PVR have been identified, including surgical intervention and detachment of long duration. [6][7][8] To increase understanding of processes involved in complex RRD beyond clinical observations, a more detailed study of retinal pathology is warranted. For the present work, we wanted to explore cellular alterations in retinas at high risk of permanent detachment.…”

Section: Introductionmentioning

confidence: 44%

Neuronal and Glial Alterations in Complex Long-Term Rhegmatogenous Retinal Detachment

Ghosh

Johansson

2012

Current Eye Research

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Purpose: To explore neuronal and glial alterations in eyes with complex long-term rhegmatogenous retinal detachment (RRD). Methods:Morphological analysis was performed on eight retinal specimens derived from patients treated with peripheral retinectomy for RRD complicated by retinal shortening or retinal thinning. All eyes had undergone previous surgeries including silicone oil tamponade, and had a median total detachment time of 2.5 months (range 2-12).Specimens were examined with hematoxylin and eosin staining and immunohistochem-

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Section: Introductionmentioning

confidence: 44%

Neuronal and Glial Alterations in Complex Long-Term Rhegmatogenous Retinal Detachment

Ghosh

Johansson

2012

Current Eye Research

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“…5 The retina can be reattached by surgery, but in roughly 10% of cases, scar tissue made up predominantly of RPE and glial cells forms in the vitreous and on the surfaces of the retina and results in traction that redetaches the retina. 8 There is prominent expression of PDGFs in the cells that participate in the scarring. This disease process is called proliferative vitreoretinopathy, the most common cause of failure of retinal reattachment surgery, and PDGFs have been implicated in its pathogenesis.…”

mentioning

confidence: 45%

Photoreceptor-Specific Expression of Platelet-Derived Growth Factor-B Results in Traction Retinal Detachment

Seo¹,

Okamoto²,

Vinores³

et al. 2000

The American Journal of Pathology

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Expression of platelet-derived growth factor (PDGF)-A and PDGF-B is increased in patients with proliferative retinopathies in which traction retinal detachments occur. Previous studies have demonstrated that increased expression of PDGF-A in the retina of transgenic mice results in retinal gliosis due to proliferation of astrocytes with different retinal phenotypes based on the time of onset and location of the PDGF-A production. In this study, we investigated the effects of PDGF-B in the retina using gain-of-function transgenic mice that express PDGF-B in photoreceptors. These mice show proliferation of astrocytes, pericytes, and, to a lesser extent, endothelial cells, resulting in ectopic cells on the surface and extending into the retina. The sheets of cells exert traction on the retina resulting in traction retinal detachments similar to those seen in humans with proliferative retinopathies. These studies suggest that PDGF-B has more dramatic effects in the retina than PDGF-A, because it acts on additional cell types, in particular on pericytes, which have a highly developed contractile apparatus. These studies in the retina suggest a means that could be used in other tissues throughout the body to achieve graded PDGF effects. They also provide a new model of traction retinal detachment that can be used to investigate new treatments for patients with proliferative retinopathies. Platelet-derived growth factor (PDGF) was isolated based on its ability to stimulate the proliferation of mesenchymal cells, and it is responsible for a substantial amount of the mitogenic activity in serum.

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“…[1][2][3][4][5][6][7][8][9] Despite this high level of anatomic success, visual results remain compromised mainly because of permanent functional damage once the macula becomes detached. 10 The most important predictor of visual recovery after retinal detachment surgery is preoperative visual acuity.…”

mentioning

confidence: 99%

Visual recovery after macula-off retinal detachment

Ross

2002

Eye

121

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With modern surgical techniques to repair retinal detachments, a greater than 90% primary anatomic success rate can be expected. [1][2][3][4][5][6][7][8][9] Despite this high level of anatomic success, visual results remain compromised mainly because of permanent functional damage once the macula becomes detached. 10 The most important predictor of visual recovery after retinal detachment surgery is preoperative visual acuity. 8,9,11,12 Preoperative acuity appears to be directly related to the height of macular detachment. 13 Shorter duration of detachment and younger age are also important in visual recovery. This paper will review the current literature that helps to improve our understanding of visual recovery after macula-off retinal detachments.

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Clinical Risk Factors for Proliferative Vitreoretinopathy

Cited by 182 publications

References 16 publications

Neuronal and Glial Alterations in Complex Long-Term Rhegmatogenous Retinal Detachment

Neuronal and Glial Alterations in Complex Long-Term Rhegmatogenous Retinal Detachment

Photoreceptor-Specific Expression of Platelet-Derived Growth Factor-B Results in Traction Retinal Detachment

Visual recovery after macula-off retinal detachment

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