Clinical Research to Clinical Practice — Lost in Translation?

Lenfant, Claude

doi:10.1056/nejmsa035507

Cited by 791 publications

(429 citation statements)

References 27 publications

Supporting

Mentioning

398

Contrasting

Unclassified

Order By: Relevance

“…Broadly, a small fraction of scientific insights is actually translated into real-world effects. And, when this does occur, the process can take decades [1][2][3][4][5]. Translation of scientific findings into widely used preventive interventions involves six interconnected stages (T0-T5, see Table 1).…”

Section: Introductionmentioning

confidence: 99%

Translating research into prevention of high-risk behaviors in the presence of complex systems: definitions and systems frameworks

Lich

Frerichs

Fishbein

et al. 2016

Behav. Med. Pract. Policy Res.

View full text Add to dashboard Cite

To impact population health, it is critical to collaborate across disciplinary and practice-based silos and integrate resources, experiences, and knowledge to exert positive change. Complex systems shape both the prevention outcomes researchers, practitioners, and policymakers seek to impact and how research is translated and can either impede or support movement from basic scientific discovery to impactful and scaled-up prevention practice. Systems science methods can be used to facilitate designing translation support that is grounded in a richer understanding of the many interacting forces affecting prevention outcomes across contexts. In this paper, we illustrate how one systems science method, system dynamics, could be used to advance research, practice, and policy initiatives in each stage of translation from discovery to translation of innovation into global communities (T0-T5), with tobacco prevention as an example. System dynamics can be applied to each translational stage to integrate disciplinary knowledge and document testable hypotheses to inform translation research and practice.

show abstract

Section: Introductionmentioning

confidence: 99%

Translating research into prevention of high-risk behaviors in the presence of complex systems: definitions and systems frameworks

Lich

Frerichs

Fishbein

et al. 2016

Behav. Med. Pract. Policy Res.

View full text Add to dashboard Cite

show abstract

“…We know that evidence diffuses into practice both slowly and inconsistently [11,25]; could the observations about increased viscosupplementation usage therefore simply represent the usual delay between discovery and implementation of evidence into clinical care? After all, the guidelines recommending against viscosupplementation are not the only ones that have yet to make the leap from paper to practice [16], and as professionals, surgeons have a reasonable aversion to ''cookbook'' medicine [24].…”

Section: ó the Association Of Bone And Joint Surgeons1 2015mentioning

confidence: 99%

Editorial: Getting Evidence Into Practice - or Not: The Case of Viscosupplementation

Leopold

2016

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

“…It ought to be reminded that observers obtain the so called efficacy in the course of preclinical and clinical studies; this efficacy is specified for MT registration; doctors obtain effectiveness in the course of clinical practice [1]. The situation when data on MT efficacy do not translate into data on effectiveness is described in the foreign literature as "lost in translation" [2][3][4]. Several authors suggest resolving this issue radically by introducing a 10-year-long moratorium on, for instance, registration clinical studies [5].…”

Section: Relevancementioning

confidence: 99%