Clinical Relevance of sHLA-G-Mediated With Better Graft Acceptance in Early Posttransplantation

Jin, Hailong; Li, C.-R.; Xiao, Li; Shi, Bingyi; Cai, Ming; Li, Z.-L.; Wang, S.; Chen, L.-P.; Zhan, Shaofeng; Li, P.-C.

doi:10.1016/j.transproceed.2012.01.141

Cited by 11 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main causes for liver transplantation included chronic hepatitis B, cryptogenic cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis (Table 1). The results revealed no significant differences between the two groups regarding sex, model for end-stage liver disease (MELD) score [17], and primary liver disease (Table 1). …”

Section: Resultsmentioning

confidence: 99%

“…polymorphism in the HLA-G gene and occurrence of graft-versus-host disease has been studied in bone marrow transplantation and other complications in solid organ transplantation [27]. Jin et al measured the level of soluble human leukocyte antigen (sHLA-G) in renal transplant patients [17]. They found that the patients with high sHLA-G levels experienced lower rejection episodes.…”

Section: Discussionmentioning

confidence: 99%

“…They found that the patients with high sHLA-G levels experienced lower rejection episodes. Therefore, they suggested that HLA-G was involved in induction of immunologic tolerance in renal transplant recipients [17]. Increased soluble level of HLA-G with expression of HLA-G in endomyocardial biopsy was reported to be associated with lower incidence of rejection episodes in heart transplant recipients [6, 28, 29].…”

Section: Discussionmentioning

confidence: 99%

“…As the expression of sHLA-G may be influenced by genetic variants of the HLA-G gene and the 14 bp insertion/deletion is a functional polymorphism, the possible association between this genetic variant and graft acceptance was investigated [16, 17]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

et al. 2014

View full text Add to dashboard Cite

Background. HLA-G molecules exhibit immunomodulatory properties that can delay graft rejection. The 14 bp insertion/deletion polymorphism (INDEL) (rs16375) influences the stability of final HLA-G mRNA and its soluble isoforms. Objective. The present study aimed to investigate the possible association between this polymorphism and the incidence of acute rejection in Iranian liver transplant recipients. Methods. Different genotypes were evaluated by PCR. The patients who had acute rejection within 6 months after transplantation were classified as acute rejection (AR) group, while others were considered as nonacute rejection (NAR) group. Results. Among the recipients, 21 patients (21%) had at least one episode of AR, while the other 79 patients (79%) had normal liver function. No significant differences were found between the two groups regarding sex, MELD score, and primary liver disease. Also, no difference was observed concerning rs16375 genotype and allele frequency (P = 0.44, OR: 0.69; CI: 0.21–2.10). Conclusion. The study results revealed no significant difference between the AR and the NAR groups regarding the 14 bp INDEL genotypes and alleles. Further studies are recommended to be conducted on other polymorphic sites as well as monitoring of serum HLA-G concentration in order to ascertain the potential implications of this marker in our population.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Assim, a indução da expressão de HLA-G em pacientes com determinadas condições clínicas pode ser alvo de interesse na prática clínica(GONZALEZ et al, 2012).Considerado como um marcador de doenças e um alvo terapêutico, o HLA-G poderá ir além dos laboratórios de pesquisa, para ter aplicabilidade também nos laboratórios diagnósticos (GONZALEZ et al, 2012) e tornar-se um antígeno alvo para imunoterapias(KOMOHARA et al, 2007).Muitos estudos têm sido realizados avaliando a aplicação clínica do HLA-G.Neste sentido, análises da quantificação de HLA-G solúvel já estão sendo utilizadas clinicamente no acompanhamento de indivíduos transplantados com pulmão e rins, com o objetivo de detectar pacientes que têm maior risco de rejeição. Assim, pacientes que apresentam níveis séricos menores de HLA-G solúvel são os Introdução pacientes que têm maior risco de rejeição, e devem ser seguidos com mais cautela(JIN et al, 2012) Cunha et al (2009). afirmam que a participação do enfermeiro tem fundamental importância para o fortalecimento da assistência pré-natal.…”

unclassified

Polimorfismo do HLA-G na transmissão materno-infantil do HIV-1

Sanches¹

View full text Add to dashboard Cite

show abstract

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Mirzakhani

Shahbazi

Oliaei

et al. 2018

Journal Cellular Physiology

View full text Add to dashboard Cite

The half-life of transplanted kidneys is <10 years. Acute or chronic rejections have a negative impact on transplant outcome. Therefore, achieving to allograft tolerance for improving long-term transplant outcome is a desirable goal of transplantation field. In contrast, there are evidence that distinct immunological characteristics lead to tolerance in some transplant recipients. In contrast, the main reason for allograft loss is immunological responses. Various immune cells including T cells, B cells, dendritic cells, macrophages, natural killer, and myeloid-derived suppressor cells damage graft tissue and, thereby, graft loss happens. Therefore, being armed with the comprehensive knowledge about either preimmunological or postimmunological characteristics of renal transplant patients may help us to achieve an operational tolerance. In the present study, we are going to review and discuss immunological characteristics of renal transplant recipients with rejection and compare them with tolerant subjects.

show abstract

Clinical Relevance of sHLA-G-Mediated With Better Graft Acceptance in Early Posttransplantation

Cited by 11 publications

References 8 publications

HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

HLA-G Polymorphism (rs16375) and Acute Rejection in Liver Transplant Recipients

Polimorfismo do HLA-G na transmissão materno-infantil do HIV-1

Immunological biomarkers of tolerance in human kidney transplantation: An updated literature review

Contact Info

Product

Resources

About