2021
DOI: 10.1016/j.lanepe.2021.100235
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Clinical performance of high-risk HPV testing on self-samples versus clinician samples in routine primary HPV screening in the Netherlands: An observational study

Abstract: Background High-risk human papillomavirus (hrHPV) testing on self-collected samples has potential as a primary screening tool in cervical screening, but real-world evidence on its accuracy in hrHPV-based screening programmes is lacking. Methods In the Netherlands, women aged 30–60 years invited for cervical screening can choose between sampling at the clinician's office (Cervex Brush) or self-sampling at home (Evalyn Brush). HrHPV testing is performed using Roche Cobas … Show more

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Cited by 45 publications
(44 citation statements)
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References 24 publications
(32 reference statements)
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“…The transition to HPV testing as the primary method of screening for cervical cancer has also been recommended, considering the higher level of the test performance and the difficulties faced by low- and middle-income countries in conducting cytology-based programs [ 2 , 52 ]. Self-sampling HPV nucleic acid testing is an additional option that has been shown to be as effective as clinical-collected samples [ 53 ], and with great potential to contribute to increasing cervical cancer screening coverage [ 54 ], and to overcoming barriers to access the health services for early diagnosis in areas with lower availability, such as rural riverside localities [ 52 , 55 ].…”
Section: Discussionmentioning
confidence: 99%
“…The transition to HPV testing as the primary method of screening for cervical cancer has also been recommended, considering the higher level of the test performance and the difficulties faced by low- and middle-income countries in conducting cytology-based programs [ 2 , 52 ]. Self-sampling HPV nucleic acid testing is an additional option that has been shown to be as effective as clinical-collected samples [ 53 ], and with great potential to contribute to increasing cervical cancer screening coverage [ 54 ], and to overcoming barriers to access the health services for early diagnosis in areas with lower availability, such as rural riverside localities [ 52 , 55 ].…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, we performed a multivariate sensitivity analysis on the sensitivity of the hrHPV self‐test while adjusting the percentage of self‐tests of all used hrHPV‐tests from 7% to 25%. In this sensitivity analysis, we adjusted the test characteristics of the hrHPV self‐test to those found by Inturissi and colleagues, where the relative sensitivity for all lesion grades was found to be lower 24 …”
Section: Methodsmentioning
confidence: 99%
“…In this sensitivity analysis, we adjusted the test characteristics of the hrHPV self-test to those found by Inturissi and colleagues, where the relative sensitivity for all lesion grades was found to be lower. 24…”
Section: Sensitivity Analysesmentioning
confidence: 99%
“…2 Indeed, the latest population-based data from the Netherlands, where selfsampling has been offered to all women in the screening program's target population, suggested a lower sensitivity of self-sampling for detection of CIN2+ compared to clinician sampling, albeit in an unpaired and nonrandomised comparison between the sampling methods. 6…”
Section: Selection Biasmentioning
confidence: 99%