2022
DOI: 10.1002/ijc.34014
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Comments on: “Meta‐analysis of agreement/concordance statistics in studies comparing self‐ vs clinician‐collected samples for HPV testing in cervical cancer screening”

Abstract: Human papillomavirus (HPV) self-sampling will be key in eliminating cervical cancer worldwide. 1 Its implementation, however, has been slow in part because validation of self-sampling tests can be costly.The meta-analysis reported by Arbyn et al considered data to identify an alternative approach which would allow for faster and less costly validation studies. 2 In this letter we discuss the adequacy of the presented evidence for such an approach in relation to women of screening age in England and other count… Show more

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“…While waiting until longitudinal evidence becomes available, selfsampling policy can be guided by the outcomes of well-designed crosssectional validation studies so as not to unduly delay its implementation. In light of the low specificity of HPV infections for the detection of CIN2+, however, studies should ideally continue to validate the performance of self-sampling tests against histologically confirmed endpoints, 88,89 even if virological endpoints appear to lead to quicker answers. 90 This work could be expedited by having access to biobanked collections of samples from primary screening populations that have been linked to subsequent CIN2+ outcomes.…”
Section: Improving the Sensitivity Of Self-sampling For The Detection...mentioning
confidence: 99%
“…While waiting until longitudinal evidence becomes available, selfsampling policy can be guided by the outcomes of well-designed crosssectional validation studies so as not to unduly delay its implementation. In light of the low specificity of HPV infections for the detection of CIN2+, however, studies should ideally continue to validate the performance of self-sampling tests against histologically confirmed endpoints, 88,89 even if virological endpoints appear to lead to quicker answers. 90 This work could be expedited by having access to biobanked collections of samples from primary screening populations that have been linked to subsequent CIN2+ outcomes.…”
Section: Improving the Sensitivity Of Self-sampling For The Detection...mentioning
confidence: 99%