Clinical outcomes with therapies for previously treated recurrent/metastatic head-and-neck squamous cell carcinoma (R/M HNSCC): A systematic literature review

Lala, Mallika; Chirovsky, Diana; Cheng, Jonathan D.; Mayawala, Kapil

doi:10.1016/j.oraloncology.2018.07.005

Cited by 69 publications

(47 citation statements)

References 49 publications

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“…Oral squamous cell carcinoma (OSCC) is a common type of oral cancer and belongs to the category of malignant tumors [1,2]. At present, the incidence of OSCC is still on the rise, and the 5-year survival rate is still about 50% [3].…”

Section: Introductionmentioning

confidence: 99%

Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p

Guo

Zhang

2020

Cancer Cell Int

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Background: Oral squamous cell carcinoma (OSCC) is a more common cancer in the world. Emerging evidence suggests that circular RNAs (circRNAs) participate in the progression of OSCC. However, the role of circ_0000140 in OSCC is still unknown. Methods: The expression of circ_0000140 and microRNA-182-5p (miR-182-5p) were assessed by quantitative realtime polymerase chain reaction (qRT-PCR). Also, cell proliferation, migration and invasion were measured by colony formation and transwell assays, respectively. Western blot (WB) analysis was used to test the levels of proliferation, metastasis and glycolysis metabolism-related proteins as well as cell division cycle 73 (CDC73) protein. Further, the extracellular acidification rate (ECAR) of cells was detected by the Seahorse XF Extracellular Flux Analyzer. The lactate acid level of cells was tested by Lactate Assay Kit. Moreover, dual-luciferase reporter was used to verify the interaction between miR-182-3p and circ_0000140 or CDC73, and RNA immunoprecipitation (RIP) assay was employed to further confirm the relationship between miR-182-3p and circ_0000140. In addition, mice xenograft models were built to measure the effect of circ_0000140 on OSCC tumor growth in vivo. Results: Circ_0000140 was lowly expressed in OSCC, and its overexpression hindered proliferation, migration, invasion and glycolysis metabolism in OSCC cells. MiR-182-5p could be sponged by circ_0000140, and its mimic could invert the suppression of circ_0000140 overexpression on OSCC progression. CDC73 could be targeted by miR-182-3p, and its silencing could reverse the inhibition of miR-182-3p inhibitor on OSCC progression. Further, overexpressed circ_0000140 reduced the OSCC tumor growth in vivo. Conclusions: Circ_0000140 might play an anti-cancer role in OSCC, which provided a novel target for clinical therapy of OSCC.

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Section: Introductionmentioning

confidence: 99%

Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p

Guo

Zhang

2020

Cancer Cell Int

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“…HNSCC frequently recurs. Once recurred, patients have dismal survivals of only~7 months 8 . Here, by targeted sequencing, we have identified two MAPK1 somatic mutations, p.D321N and p. R135K, in two cases of primary-recurrent HNSCC from Hong Kong.…”

Section: Introductionmentioning

confidence: 99%

Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma

Ngan

Poon

et al. 2020

npj Genom. Med.

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Head and neck squamous cell carcinoma (HNSCC) lacks predictive biomarkers for drug responses. By targeted sequencing, we identified two MAPK1 mutations in recurrent HNSCC, MAPK1p.D321N, and p.R135K. We previously reported an exceptional erlotinib responder with MAPK1p.E322K. Here, by in silico and drug studies, we determined functions of these two recurrence-associated MAPK1 mutations. Residues D321, R135, and E322 are in 3D proximity. MAPK1p.D321N drives marked in vivo erlotinib sensitivity, while p.R135K's effect is moderate.npj Genomic Medicine (2020) 5:17 ; https://doi.

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“…Another goal was to evaluate whether the recurrent disease affects the prognosis. Previous researchers had reported that recurrent head and neck SCC always carried a poorer prognosis . This was the first study to analyse whether there was a significant relationship between recurrent disease and prognosis in patients with untreated head and neck SCC, but unfortunately, recurrent disease was not an independent factor in SCC of all subsites.…”

Section: Discussionmentioning

confidence: 92%

Natural history of untreated squamous cell carcinoma of the head and neck

Liu

Yuan

Fang

et al. 2018

Clinical Otolaryngology

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Clinical outcomes with therapies for previously treated recurrent/metastatic head-and-neck squamous cell carcinoma (R/M HNSCC): A systematic literature review

Cited by 69 publications

References 49 publications

Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p

Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p

Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma

Natural history of untreated squamous cell carcinoma of the head and neck

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