Natural history of untreated squamous cell carcinoma of the head and neck

Liu, Fei; Yuan, Shuai; Fang, Qigen; Sun, Qiang

doi:10.1111/coa.13260

Cited by 12 publications

(10 citation statements)

References 10 publications

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“…There were some possible explanations for our interesting finding according to current literature. Firstly, the systemic inflammation and immune system was reflected by the pretreatment NLR, neutrophils are elevated by local and systemic inflammatory, and produce several cytokines and angiogenic factors, then tumour development is promoted by these agents [23]; secondly, haematological markers might be surrogate markers of cancer cachexia, which is associated with poor survival [23, 24]. Thirdly, lymphocytes are related to immune surveillance, and decreased lymphocytes mean that the ability of eliminating cancer cells is inhibited [25, 26].…”

Section: Discussionmentioning

confidence: 99%

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

Fang

Yao

et al. 2019

BMC Cancer

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Background There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status. Therefore, our goal was to analyse the oncologic safety in patients undergoing marginal mandibulectomy (MM) for cT1-2 N0 SCC of the lower gingiva. Methods Patients undergoing MM for untreated cT1-2 N0 SCC of the lower gingiva were retrospectively enrolled. The main endpoints of interest were locoregional control (LRC) and disease-specific survival (DSS). Results A total of 142 patients were included in the analysis, and a pathologic positive node was noted in 27 patients. Cortical invasion was reported in 23 patients, and medullary invasion was reported in 9 patients. The 5-year LRC and DSS rates were 85 and 88%, respectively. Patients with bone invasion had a significantly higher risk for recurrence than patients without bone invasion. However, the DSS was similar in patients with versus without bone invasion. Patients with a high neutrophil lymphocyte ratio had a higher risk for worse prognosis. Conclusions The oncologic outcome in patients undergoing MM for cT1-2 N0 SCC of the lower gingiva was favourable; bone invasion was not uncommon, but it significantly decreased the prognosis in patients undergoing MM.

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Section: Discussionmentioning

confidence: 99%

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

Fang

Yao

et al. 2019

BMC Cancer

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“…Elevation of neutrophils is a sign of local as well as systemic inflammatory responses. Neutrophils produce cytokines and angiogenic factors, and these agents play important roles in promoting tumor development; furthermore, hematological markers might be surrogate makers of cancer cachexia that are related to poor survival (24, 25). On the other hand, lymphocytes are related to immune surveillance and act by eliminating cancer cells (26).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Pediatric Parotid Cancer

Seng

Fang

et al. 2019

Front. Pediatr.

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Objective: Our goal was to evaluate the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in pediatric patients with parotid cancer. Materials and Methods: Pediatric patients with primary parotid cancer were retrospectively enrolled from several clinical centers. The associations between the clinical-pathologic variables and NLR and the prognostic significance of NLR for recurrence-free survival (RFS) and disease-specific survival (DSS) were analyzed. Results: A total of 123 patients were included. The mean NLR was 2.51 and ranged from 1.7 to 6.1. The tumor stage and disease grade were significantly related to NLR. In patients with NLR < 2.51, the 10-year RFS rate was 97%, and in patients with NLR ≥ 2.51, the 10-year RFS rate was 84%; the difference was significant ( p = 0.016). In patients with NLR < 2.51, the 10-year DSS rate was 98%, and in patients with NLR ≥ 2.51, the 10-year DSS rate was 83%; this difference was also significant ( p = 0.035). Further Cox model analysis confirmed the independence of NLR in predicting the RFS and DSS rates. Conclusions: NLR is significantly associated with prognosis in pediatric patients with parotid cancer.

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“…In current study, the overall occult metastasis rate was 17.2%, but all patients underwent END. There were at least three aspects for explaining this phenomenon: firstly, the high requirement of routine follow-up of wait-and-see policy was usually out of our patients' ability, as described by our previous studies [22,23], patients in our cancer hospital usually came from low income family and remote districts; secondly, there was abundant evidence indicating that there was often a low salvage rate on disease recurrence in patients who do not have prophylactic therapy of the clinically N0 neck [2][3][4][5], thirdly, also the most important one, there were no reliable predictors for occult neck lymph node metastasis from previous studies.…”

Section: Discussionmentioning

confidence: 87%

Depth of invasion determined by MRI in cT1N0 tongue: is it an indicator for elective neck dissection?

Yuan

Kang

et al. 2019

Preprint

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Abstracts Background Depth of invasion (DOI) could be calculated by MRI preoperatively, whether MRI-determined DOI could predict the prognosis and whether it could be used as an indicator for neck dissection for cT1N0 tongue squamous cell carcinoma (SCC) remain unknown, the main goal of the current study aimed to answer the questions. Methods Patients with surgically treated cT1N0 tongue SCC were retrospectively enrolled, MRI-determined DOI was measured based on T1-weigthed layers by a 1.5T scan. A multivariate logistic regression analysis model was used to determine the independent predictors for occult neck lymph node metastasis. The main study endpoints were locoregional control survival (LRC) and disease specific survival (DSS), the Cox model was used to determine the independent prognostic factors for the LRC and DSS. Results Occult neck lymph node metastasis was noted in 26 (17.2%) patients, ROC curve indicated the optimal cutoff value of MRI-determined DOI was 7.5mm for predicting neck lymph node metastasis with sensitivity of 86.9%. The factors of lymphovascular invasion, MRI-determined DOI, pathologic DOI, and pathologic tumor grade were significantly associated with the presence of neck lymph node metastasis in univariate analysis, further logistic regression analysis confirmed the independence of lymphovascular invasion, MRI-determined DOI, and pathologic DOI in predicting the neck lymph node metastasis. The 5-year LRC and DSS rates were 84% and 90%, respectively. Cox model analysis suggested the MRI-determined DOI was an independent prognostic factor for both the LRC and DSS. Conclusions Elective neck dissection is suggested if MRI-determined DOI is greater than 7.5mm in cT1N0 tongue SCC, and MRI-determined DOI ≥7.5mm indicates more risk for disease recurrence and cancer caused death.

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Natural history of untreated squamous cell carcinoma of the head and neck

Cited by 12 publications

References 10 publications

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

Oncologic outcome of marginal mandibulectomy in squamous cell carcinoma of the lower gingiva

Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio in Pediatric Parotid Cancer

Depth of invasion determined by MRI in cT1N0 tongue: is it an indicator for elective neck dissection?

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