Clinical Observation of a Novel, Complementary, Immunotherapeutic Approach based on Ketogenic Diet, Chondroitin Sulfate, Vitamin D&lt;sub&gt;3&lt;/sub&gt;, Oleic Acid and a Fermented Milk and Colostrum Product

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It is estimated that the first processed food products consumed by humans pertained to the category of fermented foods and beverages such as beer, wine, sauerkraut, fermented sausage as well as fermented milk derivatives such as yogurt and kefir. Thus, fermented foods are endowed with undisputed healthy properties due to the presence of probiotic microbes that not only help supporting the healthy human microbiota, but also produce bioactive or bio-available metabolites that contribute to the host's wellbeing. It is widely acknowledged that modulation of the immune system is one of the beneficial effects associated with consuming fermented food products rich in live probiotics and this effect is being exploited in the field of natural immunotherapy. Here we describe the genesis and development of a novel, non-dairy product that may represent a novelty in the field of probiotic drinks since it combines the healthy properties of dairy-based products with the properties of non-dairy probiotic drinks. The major improvements over the existing non-dairy probiotic drinks consist in the number and diversity of probiotic strains endowed with healthpromoting properties and in the presence of a glycosaminoglycan, chondroitin sulfate, that is, at the same time, a newly identified prebiotic and a supplement known to modulate the immune system.

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Description of a Novel Probiotic Concept: Implications for the Modulation of the Immune System

Pacini¹,

Ruggiero²

2017

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“…Since interpretation of ART can provide information on the potential responsiveness of the patient to different therapeutic approaches and since the involvement of the immune system in persistent Lyme is widely acknowledged, we used an emulsion of chondroitin sulfate, vitamin D 3 and oleic acid endowed with immune modulating properties as positive control (dr. reinwald healthcare, Schwarzenbruck, Germany). The characteristics of this emulsion and its potential use in integrative immunotherapy have been recently described (Schwalb et al, 2016).…”

Section: Autonomic Response Testing (Art)mentioning

confidence: 99%

The Ruggiero-Klinghardt (RK) Protocol for the Diagnosis and Treatment of Chronic Conditions with Particular Focus on Lyme Disease

Klinghardt¹,

Ruggiero²

2017

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Abstract:Here we describe the Ruggiero-Klinghardt (RK) Protocol that is based on integration of Autonomic Response Testing (ART) with diagnostic ultrasonography and on application of therapeutic ultrasounds; the latter are used as a provocation tool and as an instrument to optimize drug uptake and utilization in specific areas of the body. This protocol consists of a precise sequence of diagnostic and therapeutic procedures with the ultimate goal of improving sensitivity and specificity of diagnosis at the same time evaluating and optimizing efficacy of treatments in chronic conditions including, but not limited to, persistent Lyme disease. The RK Protocol represents a paradigm shift in diagnostics and therapeutics: Thus, compartmentalized microbes, transformed cells, toxins and metabolites could be detected using a safe and non-invasive method. In addition, the RK Protocol allows optimization of efficacy of drugs and other therapeutic interventions. Although the RK Protocol was initially developed for persistent Lyme disease, it shows significant potential in conditions ranging from cancer to neurodegenerative diseases and autism. In oncology, the RK Protocol may serve to facilitate early diagnosis and to increase sensitivity of cancer cells to the killing effects of a variety of remedies ranging from conventional radio-and chemotherapy to more recent forms of immunotherapy. Thus, the 1st goal of the RK Protocol is diagnostic: That is, to make pathogens, toxins, transformed cells and cells infected by viruses that are inaccessible to conventional diagnostic and therapeutic tools, "visible" to the therapist who can detect them with laboratory methods and deal with them with appropriate interventions; and also to make them "visible" to the immune system that can fight them in a physiological manner. The 2nd goal is to optimize drug uptake and utilization in the organs and tissues studied and targeted with these procedures.

“…In other words, we can hypothesize two different mechanisms of action: A fast response due to the interaction and remodeling of the cell membrane and a long-lasting, sustained response due to the modulation of gene expression. It is interesting to notice that these two different types of responses were observed, about thirty years later, when Rerum ® was used in the context of cancer (Schwalb et al, 2016).…”

Section: An Alternative Approach To Immunotherapy; the Role Of Glycosmentioning

confidence: 99%

“…The subcutaneous, intradermal or intramuscular routes of administration are of particular interest since these are efficient ways to prime and modulate the immune system in the context of vaccinations and immunotherapies (Herzog, 2014;Casale and Stokes, 2014) and are consistent with the observation of Prudden who reported excellent results using a combination of oral and subcutaneous administration of bovine cartilage extracts (Prudden, 1985). Using a variety of routes of administration, Rerum ® has been used in the complementary approach to cancer in patients with different malignancies; preliminary results concerning this clinical experience were published in this Journal in 2016 (Schwalb et al, 2016).…”

Section: The Development Of a Novel Approach To Glycosaminoglycan-basmentioning

confidence: 99%

Is Rerum<sup>®</sup> the New Coley's Vaccine?

Ruggiero¹

2017

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Abstract:In this article I describe the development of an alternative type of immunotherapy that traces its origins to the nineteenth century when Dr. William B. Coley successfully treated inoperable cancer patients with his vaccine. Despite the well-documented successes, the vaccine did not survive Coley's times and was forgotten and neglected for decades in favor of radio-and chemotherapy. In the mid-fifties of the last century, the concept of a therapy based on stimulation of the immune system re-emerged from oblivion even though with a profoundly diverse connotation; the interest in this approach to cancer has grown exponentially ever since, up to the point of appointing immunotherapy of cancer the" breakthrough of the year" in 2013. Most cancer immunotherapies are based on proteins that either empower the immune system or attempt to selectively kill cancer cells. There are, however, some exceptions to this protein-based approach; the pioneering work of Dr. Prudden in New York and our research work in Florence, Italy. Thus, independently of each other, we pursued an alternative concept of immunotherapy that is based on glycosaminoglycans rather than proteins. From this research, a novel, tridimensional supramolecular structure constituted by chondroitin sulfate, vitamin D 3 and oleic acid, designated Rerum ® , was developed with the intent of reviving the historical approach of Dr. Coley at the light of today's knowledge. Here, I describe the rationale for the development of Rerum ® as well as some preliminary results that were presented at