Clinical, Microbial, and Immune Responses Observed in Patients With Diabetes After Treatment for Gingivitis: A Three‐Month Randomized Clinical Trial

Raslan, Suzane A; Cortelli, José Roberto; Costa, Fernando Oliveira; Aquino, Davi Romeiro; Franco, Gilson César Nobre; Cota, Luís Otávio Miranda; Gargioni-Filho, Antonio; Cortelli, Sheila Cavalca

doi:10.1902/jop.2014.140197

Cited by 9 publications

(12 citation statements)

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“…Mechanical procedures can also be combined with chemical agents for the treatment of gingivitis and periodontitis. Clinical, microbiological, and immunological improvements have been reported after full-mouth scaling and the daily use of an essential oil (EO) mouth rinse for gingivitis treatment 13 . In addition, full-mouth scaling with the adjunctive use of chlorhexidine (CHX) reduced the probing depth, percentage of periodontal disease sites, and total subgingival bacterial counts in periodontitis patients 14 .…”

Section: Introductionmentioning

confidence: 99%

Salivary arginase activity after mechanical-chemical therapy

Castro

Cortelli

Rodrigues

et al. 2018

Rev. odontol. UNESP

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ResumoIntrodução: Componentes salivares podem ser usados como biomarcadores para diagnóstico e monitoramento de doenças orais. Há evidências de que um potencial biomarcador, arginase, está associado com os processos inflamatórios da doença periodontal, e após o tratamento sua atividade enzimática é reduzida em concordância com a melhora nos parâmetros clínicos. Objetivo: O presente estudo objetivou avaliar a atividade da arginase salivar em pacientes com gengivite e periodontite tratados com procedimentos mecânicos em estágio único combinados ao uso coadjuvante de enxaguatórios com óleos essenciais ou clorexidina, respectivamente. Material e método: Vinte e seis pacientes com gengivite e 16 pacientes com periodontite receberam exame periodontal completo antes e 3 meses após a terapia, em que mensurações de profundidade de sondagem, perda de inserção clínica, índice de placa e índice gengival foram realizadas. Nestas mesmas consultas os níveis de proteína total e a atividade de arginase salivar foram estabelecidos via espectrofotometria. Resultado: Todos os parâmetros clínicos melhoraram, em ambos os grupos, do exame inicial para o de 3 meses (p < 0,05). Adicionalmente, após tratamento para gengivite houve redução da atividade de arginase salivar e do nível de proteína total. Conclusão: Semelhante aos resultados clínicos, ambos os protocolos terapêuticos afetaram positivamente a atividade da arginase salivar; entretanto, estudos futuros são necessários para clarificar seu potencial como biomarcador salivar para o monitoramento periodontal. AbstractIntroduction: Salivary components can be used as biomarkers for diagnosing and monitoring oral diseases. There is evidence that one potential biomarker, arginase, is associated with the inflammatory processes of periodontal disease, and its enzymatic activity is reduced according to the improvement in the clinical parameters after treatment. Objective: The present study aimed to evaluate the salivary arginase activity in gingivitis and periodontitis patients treated with full-mouth mechanical procedures combined with the adjunctive use of essential oils or chlorhexidine mouthwash, respectively. Material and method: Twenty-six gingivitis and 16 periodontitis patients received complete periodontal examinations at the baseline and 3 months after therapy, in which the periodontal probing depth, clinical attachment loss, plaque index, and gingival index measurements were taken. At these same appointments, the salivary total protein level and salivary arginase activity were also established via spectrophotometry. Result: There were improvements in all of the clinical parameters (p < 0.05) evaluated from the baseline to 3 months in both groups. In addition, the salivary arginase activity and total protein levels were reduced after the gingivitis treatment. Conclusion: Similar to the clinical results, both therapeutic protocols positively affected the salivary arginase activity; however, further studies are necessary to clarify its potential as a salivary biomarker for periodont...

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Section: Introductionmentioning

confidence: 99%

Salivary arginase activity after mechanical-chemical therapy

Castro

Cortelli

Rodrigues

et al. 2018

Rev. odontol. UNESP

View full text Add to dashboard Cite

show abstract

“…16 Rinsing with essential oil mouthwash alone also reduced the levels of selected bacteria individually and the total bacterial load by half, on average, with 21% to 52% in saliva, on average 53% in supragingival plaque, and by 21% to 38% in subgingival plaque. 29 However, these reductions by oral rinse were less pronounced than after scaling and root planing in the same study (52%-63% in saliva, 68%-81% in supragingival plaque, and 68%-93% in subgingival plaque).…”

Section: Gingivitis Treatment Alone Also Has a Positive Effect On Bacmentioning

confidence: 94%

“…The frequent, but consistent, dissemination of oral microbes via the bloodstream causes a chronic inflammatory response and can occur on daily activities, as reviewed by Tomas and colleagues 8 : chewing of hard food items 9 or chewing gum, 10 tooth brushing, [10][11][12] and flossing. 13 Invasive dental procedures also can cause bacteremia, [14][15][16] for instance: tooth extraction, 11 endodontic procedures, 17,18 oral surgical treatment, 19 nonsurgical soft tissue treatment, 20 nonsurgical periodontal therapy, 10,19 and periodontal probing. 19,21 Even though bacteremia can be identified within 1 to 5 minutes after a procedure or activity, it is typically transient, with the bacteria usually undectable in the blood within 15 to 30 minutes, although bacteremia on chewing, tooth brushing, and scaling can last longer in persons with periodontitis.…”

Section: Bacteremiamentioning

confidence: 99%

“…16,72 Such 3-month routine prophylaxes also prevent progression of chronic periodontitis in both poorly controlled and well-controlled patients with type 2 diabetes mellitus. 72 After professional prophylaxis, daily use of essential oils mouth rinse for 90 days is shown to lead to a decrease in levels of overall bacterial load, T forsythia, A actinomycetemcomitans, GCF volume, and IL-1b.…”

Section: Gingivitis Treatment Only: Effect On Inflammation In Diabetesmentioning

confidence: 99%

“…72 After professional prophylaxis, daily use of essential oils mouth rinse for 90 days is shown to lead to a decrease in levels of overall bacterial load, T forsythia, A actinomycetemcomitans, GCF volume, and IL-1b. 16 …”

Section: Gingivitis Treatment Only: Effect On Inflammation In Diabetesmentioning

confidence: 99%

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