Diabetes mellitus and its many complications

Reddy, S. Sethu K.; Tan, MengHee

doi:10.1016/b978-0-12-820605-8.00001-2

Cited by 9 publications

(13 citation statements)

References 66 publications

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“…A doença renal por hiperglicemia gera lesões em várias células renais e vasculares (Amorim et al, 2019). Sendo assim, em pacientes diabéticos geralmente encontra proteína na urina indicando lesão renal (Reddy & Tan, 2020). O controle da glicemia é fundamental para retardar e prevenir a doença renal.…”

Section: Aumento Da Eliminação Renalunclassified

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

Oliveira

Domingueti

Santos

et al. 2021

RSD

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O diabetes mellitus gera um grave problema ao sistema de saúde e aos indivíduos, sendo caracterizado por um distúrbio crônico, que afeta o metabolismo de carboidratos, gorduras e proteínas. O presente estudo tem por objetivo realizar uma revisão de literatura demonstrando os mecanismos de ação da alcachofra no controle glicêmico. Foi efetuada uma busca eletrônica noScielo, Pubmed,Science direct e Google Scholar, comparando as diferentes informações encontradas nestas plataformas, listando os mecanismos de ação da alcachofra no controle glicêmico no diabetes mellitus. Foram levantados 63 artigos científicos na língua portuguesa, inglesa e espanhola, dos quais 17,5% abordaram sobre a alcachofra sua composição, conteúdos fenólicos e efeitos anti-hiperglicêmicos, 13 % descrevem sobre os polifenóis, flavonoides e sua ação anti hiperglicêmica, 16 % relata sobre a regulação da α-glicosidase, 6% aborda sobre o transporte de glicose via GLUT; 6% sobre a secreção de insulina pelas células beta pancreáticas, 13% relata a regulação do metabolismo de glicose hepática, 11 % relata a eliminação renal de glicose, 9,5% sobre o diabetes e suas complicações e 8% aborda outras plantas e compostos naturais com ação semelhante a alcachofra. De acordo com resultados a possível ação da alcachofra e seus metabólitos especiais está na inibição da alfa-glicosidase, e acrescentar sua importante ação na redução dos radicais livre, redução do glucagon, manutenção hepática do metabolismo glicêmico, proteção das células beta-pancreática, aumento nos níveis de insulina, e captação de glicose nos tecidos, sendo importante fatores na homeostase glicêmica. Por outro lado, a utilização de flavonoides é um dos alvos mais utilizados pela literatura no controle glicêmico a médio e longo prazo. Com a presente revisão é possível concluir que todas as vias mencionadas acima, torna-se algo promissor na busca por tratamento complementar do controle glicêmico de indivíduos portadores do diabetes mellitus.

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Section: Aumento Da Eliminação Renalunclassified

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

Oliveira

Domingueti

Santos

et al. 2021

RSD

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“…DFU, a chronic ulcer, is defined as the presence of tissue infection, ulceration and destruction of the foot related to peripheral neuropathy and/or peripheral artery disease in the lower extremities of patients with diabetes 6 . DFU can lead to serious problems for both patients and their family and the healthcare system owing to the high treatment cost, high amputation risk and complications such as sepsis and death 2,7,8 . The incidence of DFU remains high in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

“…The total direct medical cost in Indonesia is US$ 576 million, with 56% spent on hospitalisation, 38% on specialist visits, 4% on unbundled non‐diabetes‐related medications and 2% on unbundled anti‐hyperglycaemic medications 9 . Patients with wound complications are handled improperly or by unqualified healthcare professionals and face severe complications, which can lead to longer treatment and result in higher medical costs 7,8 . DFUs not only impose a heavy financial burden on patients and the healthcare system, but also significantly decrease quality of life (QOL), and increase morbidity and mortality 10 …”

Section: Introductionmentioning

confidence: 99%

“…6 DFU can lead to serious problems for both patients and their family and the healthcare system owing to the high treatment cost, high amputation risk and complications such as sepsis and death. 2,7,8 The incidence of DFU remains high in Indonesia. One study reported that 33.9% of patients with diabetes in a national referral hospital had DFUs.…”

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confidence: 99%

“…9 Patients with wound complications are handled improperly or by unqualified healthcare professionals and face severe complications, which can lead to longer treatment and result in higher medical costs. 7,8 DFUs not only impose a heavy financial burden on patients and the healthcare system, but also significantly decrease quality of life (QOL), and increase morbidity and mortality. 10 In Indonesia, patients with diabetes can access healthcare services at community health centres (puskesmas), hospitals of varying levels, private clinics (with specialists and non-specialists) and independent facilities such as doctors' and nurses' offices.…”

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confidence: 99%

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Evaluating the cost‐effectiveness of diabetic foot ulcer management by wound care specialists in Indonesia

Jais,

Oe,

Sanada

et al. 2024

Wound Repair Regeneration

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Diabetic foot ulcers affect quality of life and economically burden patients and the Indonesian healthcare system. The comparative cost‐effectiveness of wound care specialists in private practices (e.g., wound clinics) and wound care nurses in national hospitals remains unknown. Thus, we used a decision tree to compare the cost and healing rates for patients after 12 weeks of wound care. Uncertainty was addressed using one‐way and probabilistic sensitivity analyses. Among 89 participants (42 in the national hospital and 47 in the private practice), no significant differences were observed between the two groups in terms of sex, age, education level, smoking status, duration of diabetes, Wagner wound classification, glycated haemoglobin levels, neuropathy status, ankle‐brachial index, baseline characteristics, quality of life, DMIST (depth, maceration, inflammation/infection, size, tissue type of the wound bed, type of wound edge, and tunneling/undermining) score, and wound location (P > 0.05). However, significant differences were observed for days from first visit/assessment until complete healing, mean quality of life (P = < 0.001), and wound size (P = 0.047). Wound care specialists in private practices had a significantly lower cost of 2,804,423.3 Indonesian rupiah compared to 6,483,493.4 Indonesian rupiah for wound care nurses in national hospitals. The incremental cost‐effectiveness ratio was ‐165,723.9. Therefore, wound care specialists in private practices are more cost‐effective for managing diabetic foot ulcers. Probability sensitivity analysis confirmed that 80–90% of the scenarios were cost‐effective. These findings may inform healthcare resource allocation in Indonesia. Additionally, evidence‐based cost‐effectiveness measures were strengthened in private practices and national hospitals.This article is protected by copyright. All rights reserved.

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Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms

Sun,

Mehmood,

Giampieri

et al. 2023

Critical Reviews in Food Science and Nutrition

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Diabetes mellitus and its many complications

Cited by 9 publications

References 66 publications

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

Evaluating the cost‐effectiveness of diabetic foot ulcer management by wound care specialists in Indonesia

Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: a comprehensive review on its mechanisms

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