Clinical meaning and implications of serum hemoglobin levels in patients with rheumatoid arthritis

Padjen, Ivan; Öhler, Leopold; Studenic, Paul; Woodworth, Thasia; Smolen, Josef S.; Aletaha, Daniel

doi:10.1016/j.semarthrit.2017.03.001

Cited by 20 publications

(19 citation statements)

References 23 publications

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“…As hepcidin is influenced by inflammation and iron metabolism, results differ on the influence on Hb and disease activity associated with hepcidin on RA 16,18 . Furthermore, in the same study of patients with RA, iron metabolism was related to serum hepcidin levels cross-sectionally, but inflammation was related longitudinally 19 . Anti-IL-6 therapy decreases serum hepcidin and improves the Hb level [20][21][22] , and the effect is more marked with anti-IL-6 than anti-TNF therapy 20 .…”

Section: Discussionmentioning

confidence: 91%

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Sato

Takai

Kazama

et al. 2020

Sci Rep

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Hepcidin, a major regulator of iron metabolism and homeostasis, is regulated by inflammation. Recent studies have suggested that hepcidin and iron metabolism are involved in osteoporosis, and the aim of this study was to determine whether serum hepcidin levels are correlated with the degree of osteoporosis in patients with rheumatoid arthritis (RA). A total of 262 patients with RA (67.5 ± 11.4 years; 77.5% female) were enrolled. Serum iron, ferritin, and hepcidin levels were positively correlated each other. Multiple regression analyses revealed that the serum iron level was positively correlated with femoral T and Z scores, whereas the serum hepcidin level was not. Serum hepcidin level was correlated with the serum 25-hydroxy vitamin D level, which was in turn positively related to the femoral Z score. Serum hepcidin and serum iron were indirectly and directly related to osteoporosis in patients with RA.

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Section: Discussionmentioning

confidence: 91%

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Sato

Takai

Kazama

et al. 2020

Sci Rep

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“…Currently, standard disease activity measures provide only limited power for predicting RA outcome, particularly in patients treated with bDMARDs therapy (Smolen et al , ; de Rooy et al , ). In this context, Hb measurements might be a valuable adjunct (Padjen et al , ). The present large observational study aimed to unravel the potential roles of hepcidin and Epo in this context.…”

Section: Discussionmentioning

confidence: 99%

“…This mechanism has been perfectly adapted in an evolutionary process of continuous selection pressure exerted by serious infections (Theurl et al , ). Hepcidin acts immediately downstream of cytokines that are key regulators in RA pathogenesis, and might, although currently unproven (van Santen et al , ; Padjen et al , ), be a better parameter than haemoglobin (Hb) to predict radiographic joint damage progression. However, hepcidin also exerts direct anti‐inflammatory effects, thereby influencing serum TNFα and IL6 concentrations (De Domenico et al , ; Pagani et al , ).…”

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confidence: 99%

The links of hepcidin and erythropoietin in the interplay of inflammation and iron deficiency in a large observational study of rheumatoid arthritis

et al. 2019

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Summary Anaemia affects quality of life and radiographic outcome in rheumatoid arthritis (RA). In a cross‐sectional study with 779 patients, we assessed the prognostic potential of the major haematopoietic regulators, hepcidin and erythropoietin, comparing their serum concentrations with respect to different anaemia types, inflammatory activity, anti‐cytokine‐specific treatment effects and iron deficiency (ID) indices. The results showed that clinical disease activity was more closely associated with haemoglobin levels than with anti‐tumour necrosis factor‐alpha or interleukin 6 receptor effects. In ID, hepcidin was suppressed, independently of inflammation. Erythropoietin levels were inappropriately low in relation to the degree of anaemia, but, in contrast to low haemoglobin, not directly associated with joint damage progression. Hepcidin and erythropoietin levels are intimately connected with inflammation and ID. Interventional studies on these important targets are already in progress.

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“…Так, у больных РА с анемией показатели С-реактивного белка, СОЭ и DAS28 были выше, чем у пациентов без анемии [1,18,19,24]. Отмечена обратная корреляция гемоглобина с уровнями С-реактивного белка [9,19,20], СОЭ [17,19], шкалами активности РА, в том числе с DAS28 [15,17,20], хотя в ряде случаев такие корреляции отсутствовали [5], а значения СОЭ, С-реактивного белка и DAS28 не различались в зависимости от типа анемии (АХЗ или ЖДА) [1,18].…”

Section: оригинальные исследованияunclassified

Anemia in rheumatoid arthritis: correlation with hepcidin and adhesion molecules

Yagoda¹,

Sarithala²,

Koroy³

2018

Medical news of the North Caucasus

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Clinical meaning and implications of serum hemoglobin levels in patients with rheumatoid arthritis

Cited by 20 publications

References 23 publications

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis

The links of hepcidin and erythropoietin in the interplay of inflammation and iron deficiency in a large observational study of rheumatoid arthritis

Anemia in rheumatoid arthritis: correlation with hepcidin and adhesion molecules

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