Clinical Manifestations of Punta Toro Virus Species Complex Infections, Panama, 2009

Gundacker, Nathan; Carrera, Jean Paul; Castillo, Marlene; Díaz, Yamilka; Valenzuela, José Raúl; Tamhane, Ashutosh; Moreno, Brechla; Pascale, Juan Miguel; Tesh, Robert B.; López‐Vergès, Sandra

doi:10.3201/eid2305.161925

Cited by 14 publications

(17 citation statements)

References 9 publications

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“…Cryptic species were originally described three centuries ago [28,29], and with modern molecular techniques have been increasingly identified across multiple organisms [71][72][73][74][75]. To our knowledge, the concept of cryptic species has not been applied to viruses, however species complex occasionally has [76,77]. From the phylogenetic network of the Old World monkey simplex viruses ( Figure 1A), these viruses could be described as a series of species complexes (i.e.…”

Section: Cryptic Viral Speciesmentioning

confidence: 99%

Genomic Nucleotide-Based Distance Analysis for Delimiting Old World Monkey Derived Herpes Simplex Virus Species.

Kolb

Brandt

2020

Preprint

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Herpes simplex viruses form a genus within the alphaherpesvirus subfamily, with three identified viral species isolated from Old World monkeys (OWM); Macacine alphaherpesvirus 1 (herpes B), Cercopithecine alphaherpesvirus 2 (SA8), and Papiine alphaherpesvirus 2 (PaHV-2; herpes papio).Herpes B is endemic to macaques, while PaHV-2 and SA8 appear endemic to baboons. All three viruses are genetically and antigenically similar, with SA8 and PaHV-2 thought to be avirulent in humans, while herpes B is a biosafety level 4 pathogen. Recently, next-generation sequencing (NGS) has resulted in an increased number of published OWM herpes simplex genomes, allowing an encompassing phylogenetic analysis. In this study, phylogenetic networks, in conjunction with a genome-based genetic distance cutoff method were used to examine 27 OWM monkey herpes simplex isolates. Genome-based genetic distances were calculated, resulting in distances between Lion and Pig-tailed simplex viruses themselves, and versus herpes B core strains that were higher than those between PaHV-2 and SA8 (approximately 14% and 10% respectively). The species distance cutoff was determined to be 8.94%, with the method recovering separate species status for PaHV-2 and SA8 and showed that Lion and Pig-tailed simplex viruses (vs core herpes B strains) were well over the distance species cutoff. In conclusion, we propose designating Lion and Pig-tailed simplex viruses as separate, individual viral species, and that this may be the first identification of viral cryptic species.

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Section: Cryptic Viral Speciesmentioning

confidence: 99%

Genomic Nucleotide-Based Distance Analysis for Delimiting Old World Monkey Derived Herpes Simplex Virus Species.

Kolb

Brandt

2020

Preprint

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“…Los casos de infección por VPT en el brote de Panamá se produjeron en áreas urbanas y periurbanas. 1 El VPT, un bunyavirus transmitido por mosquitos, generalmente causa una infección leve y autolimitada en los humanos, pero puede progresar a una enfermedad febril aguda. 3…”

Section: Epidemiologíaunclassified

“…El VPT (género Phlebovirus, familia Bunyaviridae), miembro del grupo de la fiebre de la mosca de la arena, se describió inicialmente en humanos en 1966 después de haber sido aislado de un soldado en Panamá que tenía fiebre, dolor de cabeza, mialgia y leucopenia. 1…”

Section: Introductionunclassified

Virus Punta Toro: un <i>Phlebovirus</i> circulante en América

Carrasco¹,

Lozano²

2020

Revista Latinoamericana De Infectología Pediátrica

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Punta Toro Virus (genus Phlebovirus, family Bunyaviridae), a member of the sandfly fever group, was initially described in humans in 1966 after being isolated from a soldier in Panama who had a fever, headache, myalgia and leukopenia PTV, a mosquito-borne bunyavirus, usually causes a mild and self-limited infection in humans, but can progress to acute febrile illness. In both human and animal infections, the genetic determinants of the host probably contribute to the pathogenesis of flebovirus

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“…In 2009, during the dengue surveillance programme in Panama, dengue virus-negative human samples were found to contain PTV RNA strains. Of the 201 tested sera from febrile patients, 27 (13.4%) were positive for PTV [112].…”

Section: Punta Toro Virusmentioning

confidence: 99%

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

Ayhan¹,

Charrel²

2019

Vectors and Vector-Borne Zoonotic Diseases

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Sandflies show distribution in a vast geographical area from Europe to Asia, Africa, Australia, and Central and South America where they can transmit a large number of viruses. Between these viruses, the most important are grouped into the Phlebovirus genus (family Phenuiviridae). Among them, several sandfly-borne phleboviruses cause self-limiting febrile disease (sandfly fever) or central and peripheral nervous system infections. Data concerning the geographic distribution of these phleboviruses has drastically increased during the last decade in both the new and the old worlds. The current situation depicts a high viral diversity with taxonomic groups containing human pathogenic and non-pathogenic viruses. This merits to provide insight to address the question of medical and veterinary public health impact of all these viruses, which are poorly studied. To do so, integrated and translational approaches must use ecological, epidemiological, serological and direct clinical evidence. Beside, other viruses transmitted by sandflies and belonging to Rhabdoviridae and Reoviridae families can also be of veterinary and public health importance. The chapter aims to provide a comprehensive view of the sandfly-borne viral pathogens of the public health impact on humans and other vertebrates in the old and new worlds.

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Clinical Manifestations of Punta Toro Virus Species Complex Infections, Panama, 2009

Cited by 14 publications

References 9 publications

Genomic Nucleotide-Based Distance Analysis for Delimiting Old World Monkey Derived Herpes Simplex Virus Species.

Genomic Nucleotide-Based Distance Analysis for Delimiting Old World Monkey Derived Herpes Simplex Virus Species.

Virus Punta Toro: un <i>Phlebovirus</i> circulante en América

Sandfly-Borne Viruses of Demonstrated/Relevant Medical Importance

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