Clinical implementation of the sFlt-1/PlGF ratio to identify preeclampsia and fetal growth restriction: A prospective cohort study

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

“…Vascular abnormalities during pregnancy change angiogenic markers such as Flt-1 and PIGF [34]. These markers and their ratio are important in clinical monitoring of patients with preeclampsia, and they are used on a regular basis [35][36][37]. The Flt-1/PIGF ratio is increasingly used in the study of restricted intrauterine growth [38].…”

Maternal placental growth factor and soluble fms-like tyrosine kinase-1 reference ranges in post-term pregnancies: A prospective observational study

“…The maternal circulating placenta-associated proteins placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) are useful markers of, and risk factors for, preeclampsia [9] and fetal growth restriction (FGR) [10]. Dysregulated angiogenic factors, especially low "proangiogenic" PlGF and high "antiangiogenic" sFlt-1/PlGF ratio, predict several placental syndromes, including preeclampsia, FGR and other adverse outcomes [11][12][13][14][15]. Low antiangiogenic ratio (e.g sFlt-1/PlGF <38) in maternal circulation in populations with suspected preeclampsia also predict the absence of placenta-associated adverse outcomes, both preeclampsia [12] and early-onset FGR [11][12][13][14][15].…”

From first‐trimester screening to risk stratification of evolving pre‐eclampsia in second and third trimesters of pregnancy: comprehensive approach

“…A recent study by Herraiz et al 59 investigated the value of a tiered risk-stratification model, in which asymptomatic women classified initially as low or high risk based on maternal factors were rescreened using uterine artery Doppler PI at 18-22 weeks of gestation. Women considered to be at high risk of developing pre-eclampsia based on maternal factors and uterine artery Doppler PI were selected for intensive follow-up Opinion 9 at 24-28 weeks using measurement of the sFlt-1/PlGF ratio to help predict pre-eclampsia and fetal growth restriction 59,60 . The area under the receiver-operating characteristics curve (AUC) in these women was 0.98 (95% CI, 0.97-1.00) for sFlt-1/PlGF ratio at 24-28 weeks in the detection of early-onset pre-eclampsia or fetal growth restriction requiring delivery < 32 weeks, with a detection rate of 100% (95% CI, 78.5-100.0%) at a false-positive rate of 19.4% (95% CI, 14.8-25.0%) 60 .…”

“…Women considered to be at high risk of developing pre-eclampsia based on maternal factors and uterine artery Doppler PI were selected for intensive follow-up Opinion 9 at 24-28 weeks using measurement of the sFlt-1/PlGF ratio to help predict pre-eclampsia and fetal growth restriction 59,60 . The area under the receiver-operating characteristics curve (AUC) in these women was 0.98 (95% CI, 0.97-1.00) for sFlt-1/PlGF ratio at 24-28 weeks in the detection of early-onset pre-eclampsia or fetal growth restriction requiring delivery < 32 weeks, with a detection rate of 100% (95% CI, 78.5-100.0%) at a false-positive rate of 19.4% (95% CI, 14.8-25.0%) 60 . This approach to assessment appears to be very effective, providing an accurate assessment of the risk of developing early-onset pre-eclampsia and fetal growth restriction, and thereby allowing optimization of perinatal care.…”