Clinical immunology Th1 and Th2 cytokine profile of CD4 and CD8 positive peripheral blood lymphocytes in nickel contact dermatitis

Almogren, Ahmad; Adam, Mustafa Hussein; Shakoor, Zahid; Gadelrab, Mohammad Osman; Musa, Hassan Abdulaziz

doi:10.5114/ceji.2013.34365

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Similar observations on TLR4 and NF-jB involvement were made by Zoroddu et al (2014), Lin et al (2016), Oblak et al (2015) and Peana et al (2017). Almogren et al (2013) observed a predominance of a Th1 phenotype, based on cytokine expression including IL-4 and IL-10, of lymphocytes collected from patients suffering from nickel allergy, in line with commonly accepted mechanisms of contact sensitivity. Also another inflammatory mediator were shown to be induced by nickel: nickel chloride induced the expression of cyclooxygenase-2 (COX-2) mRNA in primary fibroblasts, neutrophils, RAW 264 cells, and THP-1 cells, indicating that nickel ions can induce COX-2 expression in various types of cells (Sato et al, 2016).…”

Section: Immunotoxic Activity Of Nickelsupporting

confidence: 84%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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Section: Immunotoxic Activity Of Nickelsupporting

confidence: 84%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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“…The patch test reactions were graded from no reaction to +, ++, and +++, depending on the intensity of the reaction in accordance with the recommendations of the International Contact Dermatitis Research Group and the North American Contact Dermatitis Group. 16 Statistical analysis of the data was performed using the Statistical Package for the Social Sciences version 21 (IBM, Armonk, NY, USA). The chi-square test was used to compare gender differences in the parameters.…”

Section: Methodsmentioning

confidence: 99%

“… 13 In India, potassium dichromate and nickel sulfate, in United Arab Emirates, nickel sulfate and fragrance mix, and in Kingdom of Saudi Arabia (KSA), nickel sulfate and p-phenylenediamine have been reported as common skin-sensitizing allergens. 14 - 16 Collectively, these data indicate that nickel sensitization is universally prevalent and is a leading sensitizing allergen. This study aimed to determine common sensitizing agents among patients with ACD attending the allergy clinic at King Khalid University Hospital, Riyadh, KSA.…”

mentioning

confidence: 90%

Screening for skin-sensitizing allergens among patients with clinically suspected allergic contact dermatitis

Shakoor

Al-Mutairi

Al-Shenaifi

et al. 2017

SMJ

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Objectives:To detect common skin-sensitizing agents among patients experiencing allergic contact dermatitis (ACD).Methods:This was a retrospective study of 152 patients with clinically suspected ACD who underwent patch testing in an allergy clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between January 2012 and February 2015. Of these patients, only 74 (48%) patients reacted to one or more contact allergens. This group of patients included 58 (78.4%) women and 16 (21.6%) men (mean age: 37.8±13.8 years). Patch testing was performed using the thin-layer rapid-use epicutaneous patch test panels.Results:Nickel sulfate was the most common sensitizing agent, with 26 (35.1%) patients yielding a positive result; followed by p-phenylenediamine in 17 (22.9%), butyl-tetra-phenol formaldehyde in 12 (16.2%), gold sodium thiosulfate in 10 (13.5%), and thimerosal in 6 (8.1%) patients. Nickel reactivity was significantly higher among women (41.4%) than among men (12.5%) (p<0.0001). Similarly, gold reactivity among women (15.5%) was also higher than among men (6.2%) (p≤0.02).Conclusion:The high level of skin sensitization due to nickel, PPD, and gold in patients with ACD emphasizes the need for measures to decrease exposure to these sensitizing agents.

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“…A previous study showed that the Th1 subset of NK T cells has a dominant and critical role in allergy. In addition, the immune response in Ni allergy was skewed towards a Th1 response with a minimal Th2 response [ 32 ]. The Th1 subset of NK T cells may expand locally in response to Ni.…”

Section: The Possible Role Of Nk T Cells In Metal Allergymentioning

confidence: 99%

Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis

Kumagai

Horikawa

Shigematsu

et al. 2016

IJMS

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Metal often causes delayed-type hypersensitivity reactions, which are possibly mediated by accumulating T cells in the inflamed skin, called irritant or allergic contact dermatitis. However, accumulating T cells during development of a metal allergy are poorly characterized because a suitable animal model is unavailable. We have previously established novel murine models of metal allergy and found accumulation of both metal-specific T cells and natural killer (NK) T cells in the inflamed skin. In our novel models of metal allergy, skin hypersensitivity responses were induced through repeated sensitizations by administration of metal chloride and lipopolysaccharide into the mouse groin followed by metal chloride challenge in the footpad. These models enabled us to investigate the precise mechanisms of the immune responses of metal allergy in the inflamed skin. In this review, we summarize the immune responses in several murine models of metal allergy and describe which antigen-specific responses occur in the inflamed skin during allergic contact dermatitis in terms of the T cell receptor. In addition, we consider the immune regulation of accumulated NK T cells in metal ion–induced allergic contact dermatitis.

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Clinical immunology Th1 and Th2 cytokine profile of CD4 and CD8 positive peripheral blood lymphocytes in nickel contact dermatitis

Abstract: A vast majority of studies investigating cytokine profiles in contact dermatitis (CD)

Cited by 6 publications

References 26 publications

Update of the risk assessment of nickel in food and drinking water

Update of the risk assessment of nickel in food and drinking water

Screening for skin-sensitizing allergens among patients with clinically suspected allergic contact dermatitis

Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis

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