Clinical immunogenicity of measles, mumps and rubella vaccine delivered by the Injex jet injector: comparison with standard syringe injection

Sarno, Mark J.; Blase, Erich; Galindo, Nelly; Ramírez, Roberto; Schirmer, Carl L.; Trujillo-Juarez, Daniel F.

doi:10.1097/00006454-200009000-00006

Cited by 41 publications

(20 citation statements)

References 13 publications

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“…Recently, the Injex has been shown to safely and efficaciously deliver the measles, mumps, and rubella vaccine (MMR II ) in a cohort of pediatric subjects. 3 Despite the long history of jet injectors there have been few studies of insulin administration and fewer studies still of the pharmacokinetics of insulins delivered via jet injection. Of those studies that have been performed, there have been observations of more rapid absorption 4 and increased area under the insulin concentration-time curve 5 when compared with needle syringe.…”

Section: Dear Editormentioning

confidence: 99%

Pharmacokinetics and Glucodynamics of Rapid-, Short-, and Intermediate-Acting Insulins: Comparison of Jet Injection to Needle Syringe

Sarno¹,

Bell²,

Edelman³

2002

Diabetes Technology & Therapeutics

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Section: Dear Editormentioning

confidence: 99%

Pharmacokinetics and Glucodynamics of Rapid-, Short-, and Intermediate-Acting Insulins: Comparison of Jet Injection to Needle Syringe

Sarno¹,

Bell²,

Edelman³

2002

Diabetes Technology & Therapeutics

Self Cite

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“…According to several studies, needle-free devices offer advantages including elimination of broken needles, consistent vaccine delivery, lower vaccine volume and greater antigen dispersion, elimination of accidental worker needle sticks and elimination of needle disposal [2, 3]. In humans, needle-free method caused less pain and stress at the time of vaccination [4, 5]. By analogy, a similar effect should be expected in animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of the needle-free “intra dermal application of liquids” vaccination on the welfare of pregnant sows

Temple

Escribano

Jiménez³

et al. 2017

Porc Health Manag

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BackgroundIn commercial pig production, sows are often vaccinated several times per gestation period, resulting in reduced welfare. This preliminary experiment investigated whether the needle-free IDAL vaccinator improves welfare through reduction of stress markers, improvement of behavioural and health parameters compared to traditional needle-syringe method.ResultsTwo treatments (IDAL and NEEDLE) in 6 replicate pens of gestating sows (15 sows per pen) were evaluated using Porcilis® PRRS. The frequency of sows exhibiting an acute fear (or pain) response at the time of injection was significantly lower in the IDAL sows for the four indicators studied (high pitch vocalizations, IDAL = 15.4% vs. NEEDLE = 95.6%, χ2 = 56, P < 0.0001; retreat attempts, IDAL = 2.6% vs. NEEDLE = 56.5%, χ2 = 28, P < 0.0001; turning back, IDAL = 5.1% vs. NEEDLE = 69.6%, χ2 = 36, P < 0.0001; change in behaviour, IDAL = 18% vs. NEEDLE = 95.6%, χ2 = 53, P < 0.001). Sows in the NEEDLE vaccination group had a decreased (P = 0.03) activity the day after vaccination compared to IDAL sows. No significant difference was observed for the other active behaviours and resting postures. Fearful reaction towards the assessor significantly (χ2 = 12, P = 0.001) increased in NEEDLE sows compared to IDAL sows the day after vaccination. At 48 h post-vaccination, IDAL sows tended to have lower blood C-reactive protein levels (IDAL = 21.3 μg/mL vs. NEEDLE = 35.8 μg/mL, P = 0.06) compared to NEEDLE sows. Blood Haptoglobin levels did not differ significantly between treatments 48 h post-vaccination. Chromogranin A tended to show a lower increase after the IDAL treatment, whereas salivary alpha-amylase and salivary cortisol did not differ between treatments when measured 25 min post-vaccination.ConclusionsThese preliminary results support that needle-free intradermal vaccination is a promising strategy to reduce fear and pain reaction of gestating sows during vaccination.

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“…Jet injection is a painless drug administration technique and has been used as an easy method of vaccination for highly contagious disease 12 13. It has been used as a tool for administration of heparin, midazolam, ketamine and intradermal anesthetics 14.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the jet injector in local anaesthesia for small wound sutures: a randomised clinical trial compared with the needle infiltration technique

et al. 2014

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Clinical immunogenicity of measles, mumps and rubella vaccine delivered by the Injex jet injector: comparison with standard syringe injection

Abstract: We conclude that the measles, mumps and rubella vaccine can be safely and effectively delivered by the Injex jet injector. This device therefore provides an alternative to standard needle injection and a methodology that might reduce the risk of needle stick accidents.

Cited by 41 publications

References 13 publications

Pharmacokinetics and Glucodynamics of Rapid-, Short-, and Intermediate-Acting Insulins: Comparison of Jet Injection to Needle Syringe

Pharmacokinetics and Glucodynamics of Rapid-, Short-, and Intermediate-Acting Insulins: Comparison of Jet Injection to Needle Syringe

Effect of the needle-free “intra dermal application of liquids” vaccination on the welfare of pregnant sows

Efficacy of the jet injector in local anaesthesia for small wound sutures: a randomised clinical trial compared with the needle infiltration technique

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