Pharmacokinetics and Glucodynamics of Rapid-, Short-, and Intermediate-Acting Insulins: Comparison of Jet Injection to Needle Syringe

Sarno, Mark J.; Bell, Jo; Edelman, Steven V.

doi:10.1089/152091502321118865

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…The results of the current study also extend those of a recent study performed by Sarno et al (9), who compared administration of various insulins (including lispro insulin) with jet injection to that with needle syringes. In that study, time to peak insulin levels after lispro insulin administration was shorter for the jet injector than for needle syringe injection, but a statistically significant pharmacodynamic effect could not be established.…”

Section: Discussionsupporting

confidence: 87%

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Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology

Engwerda

Abbink²,

Tack³

et al. 2011

Diabetes Care

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OBJECTIVEInsulin administered by jet injectors is dispensed over a larger subcutaneous area than insulin injected with a syringe, which may facilitate a more rapid absorption. This study compared the pharmacologic profile of administration of insulin aspart by jet injection to that by conventional insulin pen.RESEARCH DESIGN AND METHODSEuglycemic glucose clamp tests were performed in 18 healthy volunteers after subcutaneous administration of 0.2 units/kg body wt of aspart, either administered by jet injection or by conventional pen, using a randomized, double-blind, double-dummy, cross over study design. Pharmacodynamic and pharmacokinetic profiles were derived from the glucose infusion rate (GIR) needed to maintain euglycemia and from plasma insulin levels, respectively.RESULTSThe time to maximal GIR was significantly shorter when insulin was injected with the jet injector compared with conventional pen administration (51 ± 3 vs. 105 ± 11 min, P < 0.0001). The time to peak insulin concentration was similarly reduced (31 ± 3 vs. 64 ± 6 min, P < 0.0001) and peak insulin concentrations were increased (108 ± 13 vs. 79 ± 7 mU/L, P = 0.01) when insulin was injected by jet injection compared with conventional pen injection. Jet injector insulin administration reduced the time to 50% glucose disposal by ∼40 min (P < 0.0001). There were no differences in maximal GIR, total insulin absorption, or total insulin action between the two devices.CONCLUSIONSAdministration of insulin aspart by jet injection enhances insulin absorption and reduces the duration of glucose-lowering action. This profile resembles more closely the pattern of endogenous insulin secretion and may help to achieve better meal insulin coverage and correction of postprandial glucose excursions.

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Section: Discussionsupporting

confidence: 87%

“…In that study, peak insulin levels were reached in about half the time when lispro insulin was injected with a jet injector instead of a syringe. However, the glucose-lowering time-action profiles were not significantly different, the number of subjects examined was low ( n = 4), and the dose of insulin tested was relatively high (30 units for all) (9). …”

mentioning

confidence: 96%

Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology

Engwerda

Abbink²,

Tack³

et al. 2011

Diabetes Care

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“…Our results manifested that treatment with insulin jets resulted in reducing postprandial glucose excursion at the time point of 0.5 hours for both target drugs and 1.0 to 3.0 hours for the insulin alone, suggesting that the jet device can lead to the rapid effect of the target drugs on reducing hyperglycemic burden after the meal, which was consistent with previous reports that insulin and insulin analog administration by the jet injectors may achieve to a maximum insulin concentration within a shorter time as compared to the pens. [8,13] It has been reported that the time reaching to the maximum concentration delayed in the obese patients as compared to the lean patients when using the conventional injection. [14,15] However, our patients who had a higher or low body mass index showed a similar time–concentration response to the jet therapy, suggesting that this dosing device may not only control blood glucose in a normal range but also raise treatment efficacy for these subjects who have a higher body weight.…”

Section: Discussionmentioning

confidence: 99%

Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients

et al. 2017

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This study is conducted to investigate efficacy of an insulin jet injector and an insulin pen in treatment of type 2 diabetic patients. Sixty patients with type 2 diabetes were treated with rapid-acting insulin (regular insulin) and insulin analog (insulin aspart) using the jet injector and the pen in 4 successive test cycles. Postprandial glucose and insulin concentrations in blood were measured over time. Areas under curves of glucose and the insulin were calculated, and efficacy of 2 injection methods in treatment of the diabetes was compared. Regular insulin and insulin aspart administration by the jet injector showed significant decreases in plasma glucose levels as compared to the pen injection (P < 0.05). Postprandial plasma glucose excursions at the time points of 0.5 to 3 hours were obviously lower in the jet-treated patients than the pen-treated ones (P < 0.05). Postprandial plasma insulin levels were markedly higher in the jet-treated patients than the pen-treated ones (P < 0.05). Area under the glucose curve in the pen-treated patients was significantly increased as compared to the jet-treated ones (P < 0.01). Efficacy of the insulin jet injector in treatment of type 2 diabetic patients is obviously superior to the insulin pen in regulating plasma glucose and insulin levels.

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“…Previous data on the rapid-acting insulin analogs administered by the needle-free jet injector are limited. A non-randomized study has evaluated profiles of insulin lispro using jet injector technology, but the sample size was small and the dose of insulin lispro was unreasonable [5]. A study conducted by Engwerda et al in 18 healthy volunteers, using a randomized, double-blind, double-dummy, crossover study design, found that GIR-Tmax as well as INS-Tmax were significantly shorter when aspart was injected by jet injection compared to conventional pen injection [3].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies revealed that insulin administered by jet injectors is absorbed faster compared to conventional insulin pens [5][6][7][8][9]. A randomized, double-blind, double-dummy, crossover study conducted by Engwerda et al [3] showed that compared to the conventional pen, enhanced insulin absorption and reduced duration of glucose-lowering action were found when aspart was administered by the jet injector.…”

Section: Introductionmentioning

confidence: 99%

Lispro administered by the QS-M Needle-Free Jet Injector generates an earlier insulin exposure

Shi

Zhao

et al. 2016

Expert Opinion on Drug Delivery

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Pharmacokinetics and Glucodynamics of Rapid-, Short-, and Intermediate-Acting Insulins: Comparison of Jet Injection to Needle Syringe

Cited by 10 publications

References 7 publications

Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology

Improved Pharmacokinetic and Pharmacodynamic Profile of Rapid-Acting Insulin Using Needle-Free Jet Injection Technology

Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients

Lispro administered by the QS-M Needle-Free Jet Injector generates an earlier insulin exposure

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