Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse

Tao, Yingqun; Liang, Guobiao; Li, Zhiyong; Wu, Anhua; Wang, Hailong; Lu, Yicheng; Liu, Zhenyang; Hu, Guohan

doi:10.3109/02688697.2012.685780

Cited by 11 publications

(17 citation statements)

References 9 publications

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“…Various studies suggested that hormone levels, hormone receptor status, and chromosome abnormalities may affect the tendency for high-grade tumors. [21][22][23][24][25] Some studies have also shown an inverse relationship between progesterone receptor expression level and tumor histological grade and tumor recurrence. [22][23][24][25] The hormone-related molecules may be used as markers to identify low-grade and high-grade meningiomas.…”

Section: Discussionmentioning

confidence: 96%

Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center

Zhou

Yin

et al. 2013

Neurol India

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Section: Discussionmentioning

confidence: 96%

Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center

Zhou

Yin

et al. 2013

Neurol India

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“…In a metaanalysis evaluating Ki67 positivity in grade I meningiomas, the authors achieved average immunostaining of around 3% (range 1-16%), and around 4% (range 0-35%) in recurrent tumors (45). In other studies, meningiomas presenting Ki67 ≥ 3% also showed a greater tendency for recurrence (5,10,52,55,(59)(60)(61)(62)(63)(64). In contrast, some studies have not confirmed this trend based only on Ki67 (13,65,66).…”

Section: Cell Proliferation Index: Ki67mentioning

confidence: 90%

“…In this study, the median postoperative follow-up was 3.6 years, i.e., within the period that presents a higher number of recurrences. According to Tao et al (10), the higher the histological grade, Ki67, ER and AR, the higher the number of recurrences, and the finding was significant (p < 0.05). They also reported that grade I meningiomas have a recurrence risk of 7-20% after surgical resection, and this was significantly higher in meningiomas with high Ki67 (10), a finding also observed in our study.…”

Section: Cell Proliferation Index: Ki67mentioning

confidence: 93%

“…In a study of 162 meningiomas submitted to total resection, excluding those with convexity, and follow-up of 2-5 years (mean of 3 years), recurrence occurred in 32.7% of meningiomas, 25.4 % among grade I tumors (10), a result that is higher than that observed in our research. According to Tao et al (10), the median time to recurrence was ∼3 years. In this study, the median postoperative follow-up was 3.6 years, i.e., within the period that presents a higher number of recurrences.…”

Section: Cell Proliferation Index: Ki67mentioning

confidence: 99%

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Recurrence/Regrowth in Grade I Meningioma: How to Predict?

Carvalho

Silva-Martins

Magalhães³

et al. 2020

Front. Oncol.

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The HLA-G and HLA-E molecules, Ki67, progesterone (PR), estrogen (ER) and androgen receptors (AR), p53, COX-2, and HER2 were studied to assess whether the biological behavior of grade I meningiomas is related to their expression. Tissue samples from 96 patients with grade I intracranial meningiomas were analyzed by immunohistochemistry on tissue microarray blocks (TMA) using antibodies specific for HLA-G, HLA-E, Ki67, PR, ER, AR, p53, COX-2, and HER2. Meningiomas were classified as small (≤2 cm, 1.0%), medium (>2 and ≤4 cm, 32.3%), and large (>4 cm, 66.7%). Tumor size was not related to recurrence/regrowth (p = 0.486), but was significantly correlated with peritumoral edema (p = 0.031) and intratumoral calcifications (p = 0.018). Recurrent meningiomas were observed in 14.6% of cases. Immunostaining for each marker was: HLA-G 100%; HLA-E 95.6%; PR 62%; ER 2.1%; AR 6.5%; p53 92.6%; COX-2 100%; HER2 0%; Ki67, mean 2.61 ± 2.29%, median 2.1%. Primary and recurrent meningiomas showed no significant relation with HLA-E and hormone receptors (p > 0.05), except for Ki67, where a higher median was observed in recurrent tumors than in primary (p = 0.014). The larger the tumor, the more severe the peritumoral edema, and the greater the presence of calcifications. Ki67 appears to be a good biomarker of recurrence/regrowth in grade I meningiomas.

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“…Among them are Estrogen Receptor (ER), Progesterone Receptor (PR), and Fibroblast Growth Factor Receptor 1 (FGFR1). 7,8 The relationship between DR to the incidence of Meningioma and its clinical profile were elucidated.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Digit Ratio and Incidence of Meningioma and its Clinical Profiles

Brilliantika¹,

Arifin

Istiadi

et al. 2019

Bangladesh J Med Sci

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Background: Proliferation and progression of meningioma were influenced by the balance of estrogen and testosterone. Digit Ratio (DR) was a sign of prenatal exposure to estrogen and testosterone. This study intends to find the relationship between Digit Ratio and meningioma. Aim: To determine the relationship between DR and incidence of Meningioma and its Clinical Profiles (age at the onset, sex, Body Mass Indec (BMI) and histopathology grading) Methods: Analytical observational study was used with case-control design. Case group consisted of patients clinically and histopathologically diagnosed with meningioma (n=25). Patients who were not diagnosed with primary intracranial tumors were included in the control group (n=25). Matched group were conducted. Subjects of this study were patients of RSUP dr Kariadi in the period of January 2016-August 2017. This study was conducted by collecting data consisted of DR, age, sex, BMI, and grading histopathology. Tests used in this study are Chi-Square Test, Mann-Whitney Test and Fishers exact Test. Results: Digit Ratio Mean for right, left and right-left difference were 1.0041; 1.0104 and 0.0357 while for the right and left DR cutoff value 0.993; 0.989. There is a relationship between right and left Digit Ratio and incidence of meningioma (p = 0,000) with OR (Odds Ratio) Right DR = 11.17(CI95% 2,464) and OR left DR = 16,00 (CI95% 4,002 -63,975). There is a relationship between Right Digit Ratio andBMI case group (p = 0,022). There is no relationship of Digit Ratio and age at onset, gender and histopathology grading (p <0.05). Conclusion: DR is risk factor of Meningioma

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Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse

Cited by 11 publications

References 9 publications

Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center

Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center

Recurrence/Regrowth in Grade I Meningioma: How to Predict?

Correlation between Digit Ratio and Incidence of Meningioma and its Clinical Profiles

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