Clinical Features and Chest CT Manifestations of Coronavirus Disease 2019 (COVID-19) in a Single-Center Study in Shanghai, China

Cheng, Zenghui; Lü, Yong; Cao, Qiqi; Qin, Le; Pan, Zhengying; Yan, Fuhua; Yang, Wenjie

doi:10.2214/ajr.20.22959

Cited by 263 publications

(237 citation statements)

References 15 publications

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“…A wide variety of CT findings in COVID-19 have been reported in the different studies [8,9] [9]. However, all studies indicate that the main CT feature of COVID-19 pneumonia is the presence of ground glass opacities (GGO), typically with a peripheral and subpleural distribution (Fig.…”

Section: Typical Imaging Findingsmentioning

confidence: 99%

COVID-19 pneumonia: A review of typical CT findings and differential diagnosis

Hani

Trieu

Saab

et al. 2020

Diagnostic and Interventional Imaging

382

334

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a b s t r a c tThe standard of reference for confirming COVID-19 relies on microbiological tests such as real-time polymerase chain reaction (RT-PCR) or sequencing. However, these tests might not be available in an emergency setting. Computed tomography (CT) can be used as an important complement for the diagnosis of COVID-19 pneumonia in the current epidemic context. In this review, we present the typical CT features of COVID-19 pneumonia and discuss the main differential diagnosis.

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Section: Typical Imaging Findingsmentioning

confidence: 99%

COVID-19 pneumonia: A review of typical CT findings and differential diagnosis

Hani

Trieu

Saab

et al. 2020

Diagnostic and Interventional Imaging

382

334

View full text Add to dashboard Cite

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“…The reticular pattern is usually seen in COVID-19 patients with pneumonia and reticulation may increase in patients with longer disease course [8,19,31]. The reported prevalence of reticular pattern and linear opacification is very variable in the literature and has been reported between 1% and 81% [13,14,18,19,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Moreover, subpleural curvilinear lines and fibrous stripes have been reported in COVID-19 patients (Figures 5a and 5b) [14,, and both may represent the replacement of cellular components by fibrosis [14,19].…”

Section: Reticular Pattern and Linear Opacificationmentioning

confidence: 99%

“…Air bubble sign is named in the literature under different names (cystic air space, round cystic changes, air-containing space, sievehole sign, and vacuolar sign). Although its pathophysiology is unclear, it may be related to the pathological expansion of alveolar sacs or bronchioles or the absorption process of consolidation, and the reported prevalence of air bubble sign in patients with COVID-19 pneumonia ranges from 8.1% to 54.8% (Figure 8) [25,28,33,34,35,39] (Table 2).…”

Section: Air Bubble Signmentioning

confidence: 99%

Chest CT features of the novel coronavirus disease (COVID-19)

Ufuk¹,

Savaş²

2020

Turk J Med Sci

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A new type of coronavirus (2019-nCoV) is rapidly spreading worldwide and causes pneumonia, respiratory distress, thromboembolic events, and death. Chest computed tomography (CT) plays an essential role in the diagnosis of viral pneumonia, monitoring disease progression, determination of disease severity, and evaluating therapeutic efficacy. Chest CT can show important clues of 2019-nCoV disease (also known as COVID-19) in patients with an appropriate clinic. Prompt diagnosis of COVID-19 is essential to prevent disease transmission and provides close clinical observation of patients with clinically severe disease. Therefore, radiologists and clinicians should be familiar with the CT imaging findings of COVID-19 pneumonia. Herein, we aimed to review the imaging findings of COVID-19 pneumonia and examine the critical points to be considered for imaging in cases with COVID-19 suspicion.

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“…During the H1N1 viral infection, the CP therapy gave positive results, where the respiratory tract viral load, serum cytokine levels, and mortality levels were significantly reduced in the infected groups compared to their control group (36). During the SARS and MERS pandemics, CP had provided several satisfactory and successful therapeutic outcomes (37,38). In a meta-analysis from 32 studies conducted on SARS-CoV infection, the mortality rate was significantly decreased when compared to their placebo group (35).…”

Section: Convalescent Plasma (Cp) Therapy Spells a Hope For Covid-19mentioning

confidence: 99%

COVID-19: an update on diagnostic and therapeutic approaches

et al. 2020

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The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken by the government to control and prevent the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on specimens/samples, recent efficient diagnostics, and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine and convalescent plasma (CP). More research is required for further understanding of the influence of diagnostics and therapeutic approaches to develop vaccines and drugs for COVID-19.

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Clinical Features and Chest CT Manifestations of Coronavirus Disease 2019 (COVID-19) in a Single-Center Study in Shanghai, China

Cited by 263 publications

References 15 publications

COVID-19 pneumonia: A review of typical CT findings and differential diagnosis

COVID-19 pneumonia: A review of typical CT findings and differential diagnosis

Chest CT features of the novel coronavirus disease (COVID-19)

COVID-19: an update on diagnostic and therapeutic approaches

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