Clinical experiences with oligoastrocytomas WHO grade II and III

Abstract

Between April 1991 and June 2002, 39 patients with an histologically proven oligoastrocytoma WHO grade II and III were operated on in our department. Twenty-two patients were male and 17 female. Mean age was 42 years (20-67 years). The tumor was localized in the frontal lobe in 22 patients, in the temporal lobe in seven patients, in the parietal lobe in nine patients and in the occipital lobe in one patient. The leading clinical symptoms were seizures in 33 patients. Seventeen patients were operated on under local anesthesia. One operation was performed in 22 patients, two operations in eight, three operations in five, four operations in three and six operations in one patient. Histological examination showed oligoastrocytoma WHO grade II in 12 patients and WHO grade III in 27 patients. Postoperative radiotherapy was performed in 33 patients and chemotherapy in six patients. One female patient developed spinal drop metastases 10 months after the operation. One patient with a primary oligoastrocytoma grade II and five patients with a primary oligoastrocytoma grade III died during follow-up. The follow-up period was between 6 months and 25 years (mean 7 years 6 months).

Oligoastrocytoma presenting with intractable epilepsy

“…In our own series of OA in the general brain tumor population (Beckmann and Prayson 1997), the average age of presentation was 37 years. The median preoperative course, 10.5 years, was long compared to other OA series (Beckmann and Prayson 1997, Buhl et al 2004, Johannesen et al 2003, Whittle and Beaumont 1995. It has been established that patients suffering from tumor-related intractable epilepsy have a generally good prognosis, with an indolent course of their tumors.…”

“…Seizures occur in 63-85% of patients with OA as the initial presenting symptom (Tortosa et al 2003;Buhl et al 2004). Other common presenting symptoms included memory changes, headache, and speech difficulties (Buhl et al 2004). Very few studies have evaluated in any significant detail, the correlation between OA and patients who suffer from intractable epilepsy, necessitating neurosurgical excision of seizure foci.…”

Intradural extramedullary spinal spread of oligoastrocytoma

“…Histology of the metastasis showed glioblastoma. 5 The only reported case of direct spinal extension of oligoastrocytoma was by Kuroiwa, who reported a patient with a grade II cerebellar oligoastrocytoma extending in the subarachnoid space to the C2 level. 12 Leptomeningeal spread of tumour is an uncommon event and is diagnostically challenging in the absence of hard neurological or radiological evidence.…”

“…Leading presenting symptoms are seizures and headaches. [4][5][6] The mainstay of treatment today involves surgery, with adjuvant radiotherapy or chemotherapy being offered mostly in the setting of disease progression or malignant transformation. 4,7,8 Shaw et al reported a median survival time for grade II oligoastrocytoma of 7.1 years, with 5-year and 10-year survival rates of 63% and 33% in patients treated with surgery and radiotherapy.…”

Lokal metastasierendes anaplastisches Oligoastrozytom bei einem Boxer: Diagnostik, Therapieverlauf und pathologische Befunde

“…"low-grade gliomas") und anaplastischeFormen unterteilt (3,13,19). Beim anaplastischen Oligoastrozytom wird beim Menschen eine aggressive Therapiekombination ausC hirurgie, postoperativerR adiotherapie undC hemotherapie durchgeführt (3,12). Über das biologischeVerhalten anaplastischer Oligoastrozytome desH undesi st bisherw enig bekannt ( 24).…”