Clinical Evaluation of Freeze‐dried Bone Allografts in Periodontal Osseous Defects,

Mellonig, James T.; Bowers, Gerald M.; Bright, Robert W.; Lawrence, Joseph J.

doi:10.1902/jop.1976.47.3.125

Cited by 113 publications

(64 citation statements)

References 32 publications

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“…ABBM is an extensively researched material which has been successfully used alone for treatment of intra-bony and furcation defects, with a positive role in reducing PD, promoting CAL gain and enhancing defect fill in periodontal defects. 3,4,5,32 The positive results of the control group (ABBM alone) are in accordance with findings from previous studies which had failed to show significant differences between treatment with ABBM alone or combinations of ABBM with enamel matrix derivative or platelet-rich plasma (PRP). 30,39 Although the results of this study suggest that treatment with ABBM-PRF may not have provided significantly better results than those obtained with ABBM alone, the possibility for PRF to show any beneficial effects over the control group might have been masked by the fact that treatment with ABBM alone resulted in significant improvement.…”

supporting

confidence: 89%

“…2 Histologically, new bone, cementum and new periodontal ligament formation have been observed in periodontal defects treated with ABBM. 3,4 Considering its aforementioned properties, ABBM has been successfully used in regenerative treatment of intra-bony and furcation defects. 1,5 In recent years, researchers have focused on biological mediators which have the ability to enhance wound healing and improve clinical benefits of bone replacement grafts.…”

Section: Introductionmentioning

confidence: 99%

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Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.

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confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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“…24 However, in previous studies, it has been reported that FDBA and DFDBA type allograft were observed in new periodontal ligament, cement and alveolar bone formation as a percentage of 50-60% and 80 %, respectively. [25][26][27][28] Also, several studies suggested that allograft (Puros®) was superior than the other graft materials, and that it was almost as effective as autogenous graft.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

Toker

Özdemir²,

Kuzu³

et al. 2017

Cumhuriyet Dental Journal

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Objective: Ozone accelerates wound healing and increases oxygen supply. The purpose of this study was to investigate the effect of ozone therapy combined with bone allograft on bone regeneration in rats with calvarial defects, histomorphometrically and histopathologically.Material-Method: Twenty four male Wistar rats were used in this study. A 5 mm diameter critical-size defects were created in all rats using a trephine bur. The rats were divided into 4 groups; empty defect (control) (n=6), ozone application into the control defect (control+ ozone) group (n=6), defect filled with allograft (Allograft) group (n=6), ozone combined with allograft application (allograft + ozone) group (n=6). Gaseous ozone administered at 80% density for 14 days. The animals were euthanized at 8-week. Total bone area was measured histomorphometrically and osteoclast and osteoblast number were analyzed histopathologically. Results:The osteoblast numbers increased in allograft + ozone group compared to the allograft group (p<0.05). The control defects showed significantly less new bone formation than those of the allograft groups at 8 weeks (p<0.05). Total bone area was significantly higher in allograft+ozone group than those of the allograft group (p<0.05).Conclusions: Within the limitations of this study, we suggested that allograft+ozone combination increased osteoblast number and new bone area. However, further studies are needed to investigate the mechanisms of action of ozone on bone regeneration.

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“…For example, successful clinical outcomes using deproteinized cancellous bovine bone (DPBB) matrices (e.g., Bio-Oss ® ) have been reported in the treatment of periodontal and jaw bone defects [1][2][3][4][5] and in sinus lift procedures [6][7][8] . However, these allogeneic or xenogeneic bone grafts may transmit diseases and cause immune-related complications 9) .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Osteogenic Potential Between Apatite-Coated Poly(Lactide-Co-Glycolide)/Hydroxyapatite Particulates and Bio-Oss

Kim

2008

Dent. Mater. J.

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Previously, we developed a poly(lactide-co-glycolide)/nano-hydroxyapatite (PLGA/HA) composite that overcame the limitations of conventional ceramic bone substitutes. This was achieved by introducing a bone-like apatite layer on the composite to further enhance its osteogenic potential. In this study, we compared the osteogenic potential of the apatitecoated PLGA/HA particulates to that of Bio-Oss ® , a deproteinized bovine bone material. A mixture of fibrin gel and either apatite-coated PLGA/HA particulates or Bio-Oss ® was implanted into critical-size rat calvarial defects. As a control, fibrin gel was implanted alone into the defects. At eight weeks after treatment, histological examination showed new bone formation around the grafting materials, and bone formation was similar between the two groups. In the control group, bone was not regenerated and the defects were filled with fibrous tissues. This study showed that a synthetic bone graft material, apatite-coated PLGA/HA particulates, had a comparable bone regeneration potential to the bovine-derived bone graft material, Bio-Oss ® .

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Clinical Evaluation of Freeze‐dried Bone Allografts in Periodontal Osseous Defects,

Cited by 113 publications

References 32 publications

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

Comparison of Osteogenic Potential Between Apatite-Coated Poly(Lactide-Co-Glycolide)/Hydroxyapatite Particulates and Bio-Oss

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