The Effects of Allograft Combined with Ozone Therapy on Regeneration of Calvarial Defects in Rats

Toker, Hülya; Özdemir, Hakan; Kuzu, Turan Emre; Özer, Hatice

doi:10.7126/cumudj.298891

Cited by 3 publications

(2 citation statements)

References 22 publications

(15 reference statements)

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“…W okresie około dwóch tygodni po wprowadzeniu do ubytku żelu ozonowego, autorzy zaobserwowali stopniowy wzrost gęstości kości i unaczynienia oraz wykazali, że ozon wzmaga procesy naprawcze kości (24). Podobne wyniki otrzymano w leczeniu ubytków czaszki u szczurów (43).…”

Section: Kliniczne Zastosowanie Ozonoterapiiunclassified

Use of ozone in medicine and veterinary practice

Sobczyńska-Rak¹,

Żylińska²,

Polkowska³

et al. 2018

Medycyna Weterynaryjna

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SummaryOzone is a triatomic allotrope of oxygen that can be produced in specially designed machines: ozone generators (ozonators). It breaks down to dioxygen (O 2 ) and active atomic oxygen (O), which is a very strong oxidant. Due to the fact that its bactericidal, virucidal and fungicidal activities are 50 times more powerful than those of chlorine, ozone could be used in a wide range of applications, including disinfection, disinfestation and deodorization. Biochemical properties of ozone make it useful in both human and animal medicine. Ozone therapy has been applied in the treatment of cardiovascular and gastrointestinal tract diseases, many viral, bacterial and fungal infections, corneal diseases, skin disorders, as well as in inflammatory and degenerative joint diseases. Various forms of ozone are utilized for medical purposes, for example, ozone/oxygene mixture, dressing covered with ozonated water or oil, ozonated infusion fluids and ozonated autohemotherapy (AHT). Medical ozone appeared to be successful in the treatment of antibiotic-resistant infections, infected and nonhealing wounds. When properly conducted, ozone therapy is safe and non-toxic, and should therefore be widely used in veterinary and human medicine practice.

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Section: Kliniczne Zastosowanie Ozonoterapiiunclassified

Use of ozone in medicine and veterinary practice

Sobczyńska-Rak¹,

Żylińska²,

Polkowska³

et al. 2018

Medycyna Weterynaryjna

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“…Most of the previous studies (6,(16)(17)(18) have focused only on the effect of ozone therapy on bone structure in rabbits. To the best of our knowledge fewer literature study the effect of ozone gel on the socket healing of diabetic models and this was why this study was carried out to evaluate the effect of topical ozone therapy on socket healing in rabbits with induced diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Topical Ozone Therapy on Socket Healing in Rabbits With Induced Diabetes Mellitus

Shehata

Elba

Kawana

2019

Alexandria Dental Journal

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INTRODUCTION:Ozone (O3) gas is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Ozone therapy has been utilized and heavily studied for more than a century. Its effects on bone are proven and consistent. It enhance osteoblastic activity and new bone formation. Diabetes mellitus (DM) is a chronic metabolic disease that potentially affect bone metabolism, structure, and mineral density. OBJECTIVES: to evaluate histologically the possible effect of ozone therapy on bone healing after tooth extraction in rabbits with alloxan induced diabetes mellitus. MATERIALS AND METHODS Thirty adult male New Zealand rabbits weighing 1500-2500 grams (approximately six months of age) will be divided into 3 equal groups: group I;(control group), group II; (diabetic group): diabetes was induced by a single intravenous injection of alloxan in a dose of 100 mg/kg and group III:(Ozone group) rabbits was treated as in diabetic group then they was treated with ozone therapy which will be applied topically in the form of gel inside the tooth socket. Rabbits were sacrificed after six weeks. Each sample were dissected and prepared for histological evaluation. RESULTS: in diabetic group the socket showed empty central region surrounded by disorganization bony trabeculae. The bony trabeculae surrounded less vascular spaces and more fibrous tissue.in diabetic group treated with ozone therapy the socket showed complete filling of the socket with newly formed bone.The socket with newly formed bone surrounding highly vascular bone marrow. CONCLUSIONS: Ozone gel application accelerates socket healing and enhances bone formation in diabetes mellitus

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