Clinical evaluation of Bio‐Oss^®: a bovine‐derived xenograft for the treatment of periodontal osseous defects in humans

Abstract

The purpose of this study was to compare the bovine derived xenograft (BDX) Bio-Oss to demineralized freeze dried bone allograft (DFDBA) in human intrabony defects. 17 healthy patients with no systemic disease with moderate-severe periodontitis (7 males, 10 females; aged 34-67), were treated. Surgically, defects were included only if the intraosseous defect depth was >3.0 mm. Final selection included 30 defects. The sites were randomly assigned treatment with DFDBA or BDX. Soft tissue and osseous defect measurements were taken the day of surgery and 6 months post-operatively at re-entry. Average baseline PD, CAL, and surgical defect depth for the DFDBA group were not statistically different from the BDX group. No adverse healing response occurred. The results showed a statistically significant improvement in PD and AL for both materials at 6 months in 26 defects (4 defects did not respond to therapy). Soft tissue measurements for the DFDBA group included PD reduction of 2.0+/-1.3 mm, and AL gain of 2.6+/-1.6 mm, while the BDX group showed a PD reduction of 3.0+/-1.7 mm, and AL gain of 3.6+/-1.8 mm. Osseous measurements showed bone fill of 2.4 mm (46.8%) for the DFDBA group and 3.0 mm (55.8%) for the BDX group. Defect resolution was 59.4% for the DFDBA group and 77.6% for the BDX group. Statistical analysis revealed there was no statistical difference between the 2 materials in all measurements.

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

“…ABBM is an extensively researched material which has been successfully used alone for treatment of intra-bony and furcation defects, with a positive role in reducing PD, promoting CAL gain and enhancing defect fill in periodontal defects. 3,4,5,32 The positive results of the control group (ABBM alone) are in accordance with findings from previous studies which had failed to show significant differences between treatment with ABBM alone or combinations of ABBM with enamel matrix derivative or platelet-rich plasma (PRP). 30,39 Although the results of this study suggest that treatment with ABBM-PRF may not have provided significantly better results than those obtained with ABBM alone, the possibility for PRF to show any beneficial effects over the control group might have been masked by the fact that treatment with ABBM alone resulted in significant improvement.…”

“…These reductions were greater than those obtained in the present study. Conversely, Richardson et al 32 compared ABBM to demineralised, freeze-dried bone allograft (DFDBA) in human intra-bony defects and 6 months after surgery, the PD reduction was 3 mm for the ABBM group, which are lower compared to the reductions obtained in the present study. This discrepancy could be attributed to the differences in terms of study design, re-evaluation period, inclusion criteria, initial soft tissue measurements, initial defect depth and intra-bony defect configuration.…”

“…32,35 Conversely, the reduction in the depth of the defect obtained in the present study is lower compared to the reductions observed in a previous study which reported a 3.8-mm defect fill at the 18-month evaluation of defects treated with a DFDBA-PRP combination. 36 This can be attributed to the difference in the re-evaluation period, graft material and initial defect depth.…”

An evaluation of bovine derived xenograft with and without a bioabsorbable collagen membrane in the treatment of mandibular Class II furcation defects

“…Clinical reports in the literature have demonstrated that BioOssÒ (BO), a bovine derived xenograft (BDX), in combination with or without membranes has supported periodontal regeneration in furcation and periodontal osseous defects. [12][13][14] Camelo et al and Mellonig presented histologic data indicating that the use of BO either alone or under a membrane may result in regeneration of the periodontal tissues. 15,16 In 2001, Houser et al clinically evaluated BO with a bioabsorbable collagen barrier, BG in the treatment of molar furcation defects.…”

Evaluaton of the Use of Bone Implants as a Therapy for Deep Defects in the Parodoncium

“…The objective of our research was to analyse the degree of bone regeneration in infrabony defects of the paUnauthenticated Download Date | 5/13/18 4:39 AM frabony periodontal defects six or more months after the application of various bone substituents (3,10,11,12,13). Lukovic and associates conducted a clinical study that showed Cerasorb and Bioss have similar efficacies as a treatment for deep infrabony pockets (14).…”