Clinical Evaluation of a New Type of Centrifugal Pump

Abstract

The major problems with existing centrifugal pumps are leakage, mechanical trauma, and thrombus formation. In consideration of these problems, a new compact centrifugal pump system was developed. The purpose of this study was to evaluate the new centrifugal pump system clinically. Ten patients underwent open heart surgery with a centrifugal pump or a roller pump. During surgery, hemodynamic and hematological data were obtained. A pulsatile assist device in the pump circuit was used in patients with severe heart disease. There was neither operative death nor hospital mortality, and there was no difference with regard to hemodynamic data between the two groups. The centrifugal pump groups, however, had significantly lower hemolysis, especially during prolonged cardiopulmonary bypass. This centrifugal pump could also create sufficient pulsatile flow with a pulsatile assist device. Postoperative macroscopic and microscopic findings demonstrated the smooth surface of the pump without thrombus formation. This centrifugal pump system might be useful for prolonged cardiopulmonary bypass.

Centrifugal Pump and Roller Pump in Adult Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials

“…Proponents of CP technology espouse the improved blood handling characteristics of the pump compared to a RP (1,2,21,27). However, our metaanalysis did not demonstrate any difference between pump type and platelet count, PFH, and WBCs at the ECP and PDO.…”

“…1). Thirteen studies were non‐RCTs (19–31) of which three were retrospective observational designs (28–30). Four manuscripts were excluded for study methodology where RP and CP groups received different treatment regimens beyond the main arterial pump and were deemed incomparable (32–35).…”

“…There is also similar contradiction between arterial pumps for PFH formation. While certain clinical (1,22,27) and in vitro (28) studies demonstrate a higher PFH level with the RP, other studies show no difference between pump types for up to 360 min of CPB (21,23,29,33). Generally, there is not one causative factor responsible for hematologic derangements during CPB but a multitude of factors (52).…”

“…Patients with CPB times exceeding 90 min demonstrate a significantly increased OR for severe bleeding (OR = 2.3). Once bypass time exceeds 150 min (OR = 3.4) and 210 min (OR = 8.1), the risk of severe bleeding increases substantially (27). Moreover, the risk of neurologic complications reaches significance after 150 min (OR = 2.7) and 210 min (OR = 8.2).…”

Experimental Use of a Compact Centrifugal Pump and Membrane Oxygenator as a Cardiopulmonary Support System

“…Currently, a compact atraumatic centrifugal pump and membrane oxygenator are available for clinical use (2,3). The combination of these 2 devices is expected to be superior to the conventional CPB system.…”