The major problems with existing centrifugal pumps are leakage, mechanical trauma, and thrombus formation. In consideration of these problems, a new compact centrifugal pump system was developed. The purpose of this study was to evaluate the new centrifugal pump system clinically. Ten patients underwent open heart surgery with a centrifugal pump or a roller pump. During surgery, hemodynamic and hematological data were obtained. A pulsatile assist device in the pump circuit was used in patients with severe heart disease. There was neither operative death nor hospital mortality, and there was no difference with regard to hemodynamic data between the two groups. The centrifugal pump groups, however, had significantly lower hemolysis, especially during prolonged cardiopulmonary bypass. This centrifugal pump could also create sufficient pulsatile flow with a pulsatile assist device. Postoperative macroscopic and microscopic findings demonstrated the smooth surface of the pump without thrombus formation. This centrifugal pump system might be useful for prolonged cardiopulmonary bypass.

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200 words) To evaluate future changes in storm surge caused by global warming, dynamical downscaling using the Weather Research and Forecasting model was conducted for Typhoon Vera under present-and future-climate conditions and storm surge simulation using the Coupled Model of Surge, Wave and Tide. The present-climate experiment entailed dynamical downscaling using data from the Japanese 55-year Reanalysis project as the initial and boundary conditions, and the future-climate experiments entailed downscaling considering future changes simulated through sea-surface temperature ensemble experiments using the Meteorological Research Institute Atmosphere General Circulation model. The characteristics of the downscaled typhoon agreed well with the Best Track, and the future changes in the typhoon characteristics were as follows: intensification of the central pressure, delayed decline in the high-latitude area, and westward track migration. Present-climate storm surge simulation executed using these downscaling results after correcting for the track error agreed with the observed surge, but the storm surges under future-climate conditions were underestimated because of differences in the typhoon track and surface roughness. Storm surge simulations were conducted using an empirical typhoon model; the results suggest a storm surge of 26 cm (average of the ensemble)at Nagoya Port, which is located in the innermost region of Ise Bay. 3

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