Clinical evaluation of a dressing with poly absorbent fibres and a silver matrix for managing chronic wounds at risk of infection: a non comparative trial

Dalac, S.; Sigal, Leonard H.; Addala, A.; Chahim, M.; Faivre-Carrère, Caroline; Lemdjadi, Z.; Bohbot, Serge

doi:10.12968/jowc.2016.25.9.531

Cited by 13 publications

(4 citation statements)

References 32 publications

(51 reference statements)

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“…Silver wound dressings have been developed in several ways, some binding nanocrystalline silver to carbon fibers, attaching it to polyurethane foam, attaching it to hydrocellular foam and coating it over polyethylene. Silver can either be presented at the surface of the product facing the wound, diffusing and acting on the wound itself, or be bound inside a foam or mesh acting on the pathogens absorbed into the material [15,16]. In a favorable environment silver cations can be released into the wound for several days from a single dressing [17], avoiding frequent dressing changes and unnecessary wound manipulation.…”

Section: Silver Active Compoundsmentioning

confidence: 99%

Contribution of Topical Agents to Wound Healing

Voljč¹,

Semenič²

2022

Recent Advances in Wound Healing

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The process of wound healing is often accompanied by bacterial infection or critical colonization, which leads to an extension of the inflammatory response phase and delayed epithelization. In the review of scientific articles, we found the description and mode of action of topical antiseptic agents, including silver and sodium hypochlorite solution, to control the spread of microorganisms. The value of hyaluronic acid for wound healing is described. Furthermore, a novel treatment option with microspheres is mentioned. Attachment of cells to microspheres establishes a local cytokine response that acts anti-inflammatory, cell attachment results also in morphological and functional cell changes that reactivate healing.

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Section: Silver Active Compoundsmentioning

confidence: 99%

Contribution of Topical Agents to Wound Healing

Voljč¹,

Semenič²

2022

Recent Advances in Wound Healing

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“…This subjective score, used in previous clinical studies, is calculated on the basis of nine parameters (efficacy, safety, preservation of granulation tissue, pain during dressing removal, management of exudate, handling, conformability of the dressing, patient comfort and acceptability of the dressing), using for each parameter a qualitative five-point scale ranging from 4:very good, 3:good, 2:fair, 1:poor, to 0:very poor. 25,26 The higher the score, the better the dressing performance.…”

Section: Endpointsmentioning

confidence: 99%

Evaluation of TLC-NOSF dressing with poly-absorbent fibres in exuding leg ulcers: two multicentric, single-arm, prospective, open-label clinical trials

et al. 2019

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To assess the efficacy, safety and acceptability of a new TLC-NOSF dressing with poly-absorbent fibres in the management of exuding leg ulcers, at the different stages of healing. Method: This work presents the results of two prospective, multicentric clinical studies: NEREIDES and CASSIOPEE. Patients with a non-infected, moderate-to-strongly exudating leg ulcer of venous or mixed origin, were treated with the dressing and an appropriate compression system for 12 weeks. The wounds included in NEREIDES had to be in debridement stage, and those in CASSIOPEE at granulation stage. In both studies, the primary outcome was the relative wound area reduction (RWAR) at week 12. Main secondary outcomes included healing rate, time-to-reach wound closure, adverse events and acceptability of the dressing by patients and health professionals. Results: There were 37 patients included in NEREIDES and 51 in CASSIOPEE. The two cohorts presented similar patient and wound characteristics, except from the percentage of sloughy tissue on wound bed at baseline (median: 75% NEREIDES and 30% CASSIOPEE). At week 12, the RWAR (60% NEREIDES and 81% CASSIOPEE), wound closure rates (18% NEREIDES and 20% CASSIOPEE) and mean times-to-reach wound closure (58±27 days NEREIDES and 55±23 days CASSIOPEE) supported the beneficial outcomes of the treatment in both cohorts. In patients with a wound duration ≤6 months, the wound area reduction reached 85% in NEREIDES and 81% in CASSIOPEE, highlighting the importance to initiate adequate treatment as soon as possible. The nature and frequency of the local adverse events were similar in both studies and consistent with the good safety profiles of the polyabsorbent fibres and of the TLC-NOSF dressings. The acceptability of the dressing (easy to apply, conformable and non-adherent to the wound bed at removal, with no pain or bleeding at removal) has been judged 'very good' or 'good' at each stage of the healing process, by both nursing staff and patients. Conclusion: These clinical results establish the new TLC-NOSF dressing with poly-absorbent fibres (UrgoStart Plus, Laboratoires Urgo) as an effective, safe and simple treatment for the local management of leg ulcers, at the different stages of healing and until wound closure. Declaration of interest: This study was supported by a grant from Laboratoires Urgo. C. Tumba, S. Bohbot, and O. Tacca are employees of Laboratoires Urgo. ML. Sigal and S. Meaume have received monetary compensation as speakers for Laboratoires Urgo. Data management and statistical analyses were conducted independently by Altizem. V enous leg ulceration (VLU) is a common and serious medical condition, affecting 1% to 3% of the older population in Western countries. 1-3 These chronic wounds are known to be painful and distressing, with considerable impact on patients' clinical trial • sucrose octasulfate dressing • TLC-NOSF dressing • UrgoStart • venous leg ulcers quality of life (QoL). 4 Their management can be substantially expensive and time-consuming for both health-care systems and...

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“…Although a variety of materials can be used to treat acute or chronic skin wounds, the underlying mechanism involves materials that can help establish key interactions with host cells in ways that unlock the patient's innate powers of regeneration (e.g., see Dalac et al. ; Nasiri et al …”

Section: Outlook and Future Directionsmentioning

confidence: 99%

The Critical Role of Cell Homing in Cytotherapeutics and Regenerative Medicine

Wang

et al. 2018

Advanced Therapeutics

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Recent advances in cell science and regenerative therapies mimic the therapeutic effects of patients' own cells when they home to and accumulate at sites of injury. Inspired by stem cell trafficking under in vivo conditions, the facilitation of stem cell homing and the driving of endogenously mobilized mesenchymal stem cells (MSCs) for advanced therapeutics have shown indisputable success in several preclinical studies. In fact, stem cell homing is also relevant for cell transplantation. Ensuring that a sufficient number of transplanted cells arrive at the targeted region is a prerequisite for treatments to be successful, particularly when culture-expanded cells are injected intravenously. In this progress report, the authors discuss the important role of cell homing following i) the delivery of ex vivo-manipulated cellular materials, ii) the transplantation of bone marrow in a bone marrow transplant procedure, and iii) endogenous cell mobilization/recruitment in response to injury and disease. Considering a paradigm shift from in vitro tissue engineering to in situ tissue regeneration, current endeavors and future potential in the topics of chemokine-guided cell homing and the design of cell-comfortable scaffolds that combine both biochemical and biophysical cues for immunomodulation and in situ tissue regeneration are highlighted.

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Clinical evaluation of a dressing with poly absorbent fibres and a silver matrix for managing chronic wounds at risk of infection: a non comparative trial

Abstract: These clinical data support that the tested dressing is a credible therapeutic alternative for the management of chronic wounds at risk of infection with inflammatory signs suggesting heavy bacterial load.

Cited by 13 publications

References 32 publications

Contribution of Topical Agents to Wound Healing

Contribution of Topical Agents to Wound Healing

Evaluation of TLC-NOSF dressing with poly-absorbent fibres in exuding leg ulcers: two multicentric, single-arm, prospective, open-label clinical trials

The Critical Role of Cell Homing in Cytotherapeutics and Regenerative Medicine

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