Clinical efficacy of norepinephrine combined with cimetidine in treatment of neonatal upper gastrointestinal hemorrhage and its adverse reactions

Dong, Xuyan; Liu, Hongjun; Zhu, Tianjiao

doi:10.12669/pjms.38.8.5732

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…SOD can promote the metabolism of oxygen-free radicals 20, and MDA reflect the level of peroxidation. 20,21 Our results show that a combined metforminliraglutide regimen led to significant improvement in all indicators after three months of treatment compared to metformin treatment alone.…”

Section: Discussionmentioning

confidence: 70%

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Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome

Liu

2023

Pak J Med Sci

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Objective: This study evaluates the impact of metformin combined with liraglutide on the glucose and lipid metabolism, oxidative stress, and vascular endothelium of patients with type-2 diabetes mellitus (T2DM) and metabolic syndrome. Methods: Medical records of 78 patients with T2DM and metabolic syndrome, admitted to Caoxian People’s Hospital from July 2021 to July 2022, were retrospectively analysed. Thirty five patients were treated with metformin (control group), and 43 patients were treated with metformin combined with liraglutide (observation group). Indexes of glucose and lipid metabolism, function of vascular endothelium and the oxidative stress of both groups were compared before and after the treatment. Results: There was a significant decrease in the levels of fasting plasma glucose (FPG), Glycosylated Hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist circumference in both groups three months after the treatment, These indexes were significantly lower in the observation group compared to the control group (P<0.05). High-density lipoprotein cholesterol (HDL-C) levels were higher in the observation group (P<0.05). There was a significant improvement in the levels of nitric oxide (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), and malondialdehyde (MDA) after the treatment, and these indexes were markedly better in the observation group compared to the control group (P<0.05). Conclusions: Metformin combined with liraglutide treatment is associated with better outcomes than metformin alone in patients with T2DM and metabolic syndrome. Combined treatment results in improved glucose and lipid metabolism, vascular endothelial function, and oxidative stress index values. doi: https://doi.org/10.12669/pjms.40.1.7936 How to cite this: Liu Z. Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome. Pak J Med Sci. 2023;39(6):26-30. doi: https://doi.org/10.12669/pjms.40.1.7936 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 70%

“…SOD can promote the metabolism of oxygen-free radicals 20 , and MDA reflect the level of peroxidation. 20 , 21 …”

Section: Discussionmentioning

confidence: 99%

Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome

Liu

2023

Pak J Med Sci

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“…In clinical practice, norepinephrine was often used for gastrointestinal surgery such as endoscopic submucosal dissection, or the treatment of upper gastrointestinal bleeding diseases [8,19,20] . However, there have been no reports on the combined use of norepinephrine during MAMIR surgery.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of norepinephrine application in Mammotome-assisted minimally invasive resection for benign breast neoplasm: A retrospective study Running title：norepinephrine application in benign breast neoplasm

Sun,

Xu,

et al. 2024

Preprint

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Objective Although Mammotome-assisted minimally invasive resection (MAMIR) has been widely accepted for treating breast benign nodules, the procedure remains very technical and challenging. The present study aimed to assess the efficacy of norepinephrine application in MAMIR concerning intraoperative hemorrhage, postoperative pain and postoperative hospitalization. Methods A total of 306 patients with breast nodules admitted at the Xishan people’s Hospital of Wuxi City between June 2021 and July 2023 were included in this retrospective cohort study. Univariate and multivariate analyses were performed to estimate the odds ratio (OR) and the 95% confidence intervals (CIs) for outcomes. Results A total of 155 who accepted MAMIR were included in this study. Univariable analysis indicated that bilateral nodules, operation time and intraoperative hemorrhage were risk factors for increasing postoperative hospitalization, while the usage of norepinephrine during operation helped to reduce postoperative hospitalization (P < 0.05), but none of them were independent factors influencing postoperative hospitalization according to the multivariable analysis (P > 0.05). Furthermore, multivariate analysis identified the usage of norepinephrine during MAMIR as an independent factor associated with reducing intraoperative hemorrhage (OR = 0.11, 95%CI: 0.05–0.26, P < 0.001) and relieving postoperative pain (OR = 0.02, 95%CI: 0.004–0.08, P < 0.001). Conclusions Norepinephrine could help to reduce postoperative hospitalization and intraoperative hemorrhage, also relieve postoperative pain for breast benign nodules resection, which was an independent protective factor for relieving postoperative pain and reducing intraoperative hemorrhage.

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“…MDA and LHP are oxidative metabolites, whose levels are increased in many hypoxic diseases. According to the study of Dong et al ., children with UGIB had an increased level of serum MDA and a decreased level of SOD, and the oxidative stress was relieved after successful haemostasis [ 20 ]. The above findings suggest that oxidative stress and bleeding form a vicious circle and create a cause and effect with each other.…”

Section: Discussionmentioning

confidence: 99%

Effects of gastrointestinal endoscopy at different time points on diagnosis and treatment of upper gastrointestinal bleeding in patients with liver cirrhosis.

Sun,

Zhou,

Shu

et al. 2023

Videosurgery and Other Miniinvasive Techniques

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Introduction Liver cirrhosis is a common diffuse and persistent liver disease in the gastroenterology department. Aim To assess the effects of gastrointestinal endoscopy at different time points on the diagnosis and treatment of upper gastrointestinal bleeding (UGIB) in patients with liver cirrhosis. Material and methods The clinical data of 102 liver cirrhosis patients with UGIB admitted from July 2020 to May 2022 were retrospectively analysed. According to the timing of the first gastroscopy after hospitalization, the patients were divided into 4 groups: Group A (n = 25, gastroscopy performed within 12 h of the first bleeding), Group B (n = 29, gastroscopy performed within 12–48 h of the first bleeding), Group C (n = 25, elective gastroscopy performed > 48 h after the first bleeding), and Group D (n = 23, emergency gastroscopy was conducted due to active bleeding manifestations after failure of medication). Results The success rate of haemostasis in Group A was higher than in Groups B–D (p < 0.05). The early rebleeding rates of the 4 groups were similar (p > 0.05). After treatment, the levels of serum malondialdehyde and lipid hydrogen peroxide declined but the levels of glutathione peroxidase and superoxide dismutase rose in all groups compared to those immediately after hospitalization (p < 0.05), and these indicators were improved more significantly in Group A (p < 0.05). Conclusions Gastroscopy performed within 12 h of the first bleeding is more conducive to improving the haemostatic effect and thus shortening the length of hospital stay.

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Clinical efficacy of norepinephrine combined with cimetidine in treatment of neonatal upper gastrointestinal hemorrhage and its adverse reactions

Cited by 3 publications

References 21 publications

Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome

Efficacy of metformin combined with liraglutide on the glucose and lipid metabolism, vascular endothelial function, and oxidative stress of patients with T2DM and metabolic syndrome

The efficacy of norepinephrine application in Mammotome-assisted minimally invasive resection for benign breast neoplasm: A retrospective study Running title：norepinephrine application in benign breast neoplasm

Effects of gastrointestinal endoscopy at different time points on diagnosis and treatment of upper gastrointestinal bleeding in patients with liver cirrhosis.

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