Clinical efficacy of nanosilver and chlorhexidine in the treatment of plaque-induced gingivitis: a randomized controlled clinical trial

Abstract

Clinical efficacy of nanosilver and chlorhexidine in the treatment of plaque-induced gingivitis: a randomized controlled clinical trial.

Smart dental materials for antimicrobial applications

“…In the case of antimicrobial polymers, although they overcome some drawbacks of the leachable chemical therapies such as long-term activity (no leaching or exhaustion of the antimicrobial compound), limited toxicity against mammalian cells, reduced antimicrobial resistance, and increased chemical stability [ 163 ]; significant limitations remain regarding the high selectivity against gram-positive strains and high cost of manufacturing [ 163 ]. Finally, although several clinical trials have successfully evaluated the use of NPs in different dental materials as antimicrobial agents [ [164] , [165] , [166] , [167] , [168] ], the wide use of NPs in clinical practice is limited due to concerns regarding the release of toxic ions that could cause inflammation, immunotoxicity, cytotoxicity, and genotoxicity in healthy cells. For example, titanium NPs released from implants after decontamination via ultrasonic tips and lasers cause a strong systemic immune response [ 169 , 170 ].…”