Comparison of the antibacterial effect of nanosilver and chlorhexidine mouthwash on Streptococcus mutans (invitro)

Rabani, Maryam; Aref, Parissa; Askarizadeh, Nahid; Ashrafitamay, Iraj

doi:10.29252/ijpd.15.1.93

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…NPAg are also used in dental appliances. It has been shown that a resin composite incorporated into materials containing NPAg exerts a long-lasting inhibitory effect against Streptococcus mutans (Faiyaz et al 2019;Rabani et al 2019;Yoshida et al 1999). It has also been shown that a resin composite containing fillers implanted with silver ions releases antimicrobial silver ions on oral streptococci (Corrêa et al 2015).…”

Section: Disinfecting Activity Ag/tio2mentioning

confidence: 99%

Silver nanoparticles – possible applications and threats

Kędzierska

Miłowska

2021

FBOe

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Silver is known for its biocidal properties. This metal has been used for decorations and food preservation since ancient times and has also been used in medicine. Silver foil has been used to cover wounds and burns. In addition, silver solutions were created to help fight the microorganisms responsible for causing infections, which helped the wound healing process. Currently, to increase and optimize the properties of silver, it is used on a nanometric scale. Nanosilver, due to its expanded spectrum of properties, is used in many economic sectors, including in the production of disinfectants and food films, as well as in animal farms. Nanoparticles are also the basis of nanomedicine action. Creating new drug complexes with nanosilver and modifying the medical materials used in implantology or dentistry allow the lives of many people to be saved every day. In addition, nanosilver particles are commonly used as a specific disinfectant in the production of hospital materials: dressings, bandages, surgical masks, hospital clothing and shoes, and equipment. With the growing use of nanosilver, there are concerns about its harmful effects on living organisms, because not all its mechanisms of action are known. As is well known, the dose determines the toxicity of a given substance; the case is similar for nanosilver. However, is the dose providing antibacterial and antifungal properties non-toxic to animals and humans? This review presents a summary of the scientific research showing the scope of nanosilver activity and the resulting threats.

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Section: Disinfecting Activity Ag/tio2mentioning

confidence: 99%

Silver nanoparticles – possible applications and threats

Kędzierska

Miłowska

2021

FBOe

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“…One of the advantages of chlorhexidine is its ability to adhere to oral tissues, allowing it to release slowly and provide antimicrobial effects over a certain period of time. The mechanism of action of chlorhexidine is adherence to the bacterial cell wall [ 6 ]. Due to its property of substantivity, chlorhexidine adsorbs to tooth surfaces destabilizes bacterial cell walls and interferes with cellular osmosis, leading to lysis of bacterial cells.…”

Section: Introductionmentioning

confidence: 99%

“…Long-term use of chlorhexidine can result in discoloration of teeth, restorations, oral mucosa, and tongue dorsum. In addition, bad taste, xerostomia, and detrimental effects of oral microflora is other disadvantages of chlorhexidine [ 6 ]. Therefore, researchers have sought other antimicrobial agents for using as mouthwash [ 6 , 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of antimicrobial and wound-healing effects of silver nanoparticle and chlorhexidine mouthwashes: an in vivo study in rabbits

et al. 2022

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The objective is to formulate a silver nanoparticle mouthwash and then evaluate its antimicrobial and wound-healing effects in rabbit animal models. Microbial samples were collected from the oral cavity of 60 rabbits. Thereafter, standardized wounds were created in the lateral border of the tongue on the right side for all rabbits. After surgery, digital photographs were obtained from the wounds with standardized settings. To characterize the silver nanoparticles used in the synthetic mouthwash, transmission electron microscopy (TEM) and digital light scattering analysis were used. The animal models were then randomly divided into 4 groups: group 1 received 9.80 wt% silver nanoparticle mouthwash; group 2 received all the ingredients of the formulated mouthwash except for silver nanoparticles; group 3 received chlorhexidine 2.0% mouthwash; and the negative control group did not receive any postoperative mouthwash. Microbial samples were collected from oral cavity of the rabbits each day for four postoperative days. Colony-forming unit (CFU) counts were compared post-operatively with the pre-operative counts. In addition, standardized digital photographs were taken each day from the wounds and the area of the wounds was compared in postoperative and pre-operative images. Data were statistically analyzed using one-way ANOVA and repeated measures variance analysis (α = 0.05). TEM revealed spherical morphology of silver nanoparticles and digital light scattering showed an average size of 5 nm and optimal distribution of the nanoparticles. CFU count significantly decreased in groups 1 and 3 (P < 0.001), while it significantly increased in groups 2 and 4 (P < 0.001). Moreover, a significant difference was observed between the experimental groups (P < 0.001). In addition, wound area decreased significantly in all groups (P < 0.001). However, the difference between wound areas in the groups was not significant, except for the 4th postoperative day (P < 0.001). However, the antibacterial effects and the wound-healing characteristics of the synthetic silver nanoparticle and chlorhexidine mouthwashes were not significantly different (P > 0.05). Silver nanoparticle mouthwash possesses favorable antibacterial and wound-healing effects. The formulated 9.80 wt% silver nanoparticle mouthwash with a particle size of 5 nm can be a promising alternative for application after oral surgical procedures.

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Antimicrobial effect of novel gold nanoparticle oral rinse in subjects undergoing orthodontic treatment: An ex-vivo study

et al. 2022

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Comparison of the antibacterial effect of nanosilver and chlorhexidine mouthwash on Streptococcus mutans (invitro)

Abstract: Comparison of the antibacterial effect of nanosilver and chlorhexidine mouthwash on Streptococcus mutans (invitro)

Cited by 3 publications

References 29 publications

Silver nanoparticles – possible applications and threats

Silver nanoparticles – possible applications and threats

Comparison of antimicrobial and wound-healing effects of silver nanoparticle and chlorhexidine mouthwashes: an in vivo study in rabbits

Antimicrobial effect of novel gold nanoparticle oral rinse in subjects undergoing orthodontic treatment: An ex-vivo study

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