2016
DOI: 10.1902/jop.2016.150665
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Clinical Effects of Lactobacillus rhamnosus in Non‐Surgical Treatment of Chronic Periodontitis: A Randomized Placebo‐Controlled Trial With 1‐Year Follow‐Up

Abstract: The results of this trial indicate that oral administration of L. rhamnosus SP1 resulted in similar clinical improvements compared with SRP alone.

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Cited by 95 publications
(154 citation statements)
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References 40 publications
(55 reference statements)
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“…The study of Della Ricca et al [27] was classified as doubleblinded by the authors, however its veracity appeared questionable as no placebo group was used. A total of ten studies were placebo-controlled [16][17][18]22,[28][29][30][31][32][33], whilst the remainder were paired-comparison studies [23,27]. Both parallel [16,17,22,[28][29][30]33] and split-mouth designs [29] were identified within the RCTs.…”
Section: Study Characteristicsmentioning
confidence: 99%
“…The study of Della Ricca et al [27] was classified as doubleblinded by the authors, however its veracity appeared questionable as no placebo group was used. A total of ten studies were placebo-controlled [16][17][18]22,[28][29][30][31][32][33], whilst the remainder were paired-comparison studies [23,27]. Both parallel [16,17,22,[28][29][30]33] and split-mouth designs [29] were identified within the RCTs.…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Both groups showed improvements in clinical parameters at all time points evaluated. However, there were no differences between groups in any visit [125,126].…”
Section: Probiotics and Periodontitismentioning
confidence: 73%
“…The bacteria most frequently used as probiotic are L. reuteri (DSM 17938 + ATCC PTA 5289) [72,[118][119][120], Lactibacillus salivarius WB21 [121,122], L. reuteri (ATCC 55730 + ATCC PTA 5289) [123], L. reuteri (ATCC PTA 5289) [61], Streptoccus oralis KJ3 + Streptococcus uberis KJ2 + Streptoccus rattus JH145 [124] and L. rhamnosus SP1 [125].…”
Section: Probiotics and Periodontitismentioning
confidence: 99%
“…Parece que os agentes foram bastante benéficos em bolsas profundas, promovendo a redução da profundidade de sondagem e da bolsa como um todo, evitando o debridamento cirúrgico, porém, em curto prazo de acompanhamento 23 . Isso pode ocorrer devido à substituição microbiana existente na bolsa, reduzindo as bactérias anaeróbias presentes e incrementando os resultados da terapia não cirúrgica.…”
Section: Discussionunclassified
“…Em um período de acompanhamento de 12 meses, ambos os grupos demonstraram reduções na profundidade de sondagem (PS) em bolsas rasas e médias, mas o grupo teste obteve redução estatisticamente significante da PS, em pacientes que possuíam bolsas maiores que 6 mm (p<0,05). Isso reduziu, de forma importante, a necessidade de cirurgia para o grupo que consumiu os probióticos, diferentemente do grupo placebo 23 . Os mesmos pesquisadores, em outro estudo, com pacientes com DP, após a RAR, compararam os efeitos de sachês de Lactobacillus rhamnosus (com 3 meses de consumo) com comprimidos de 500 mg de azitromicina (uma vez ao dia, por 5 dias).…”
Section: Periodontiteunclassified